ID   GAR5A_BOVIN             Reviewed;         215 AA.
AC   Q32L49;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 2.
DT   25-MAY-2022, entry version 56.
DE   RecName: Full=Golgi associated RAB2 interactor protein 5A;
GN   Name=GARIN5A; Synonyms=FAM71E1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: RAB2B effector protein which promotes cytosolic DNA-induced
CC       innate immune responses. Regulates IFN responses against DNA viruses by
CC       regulating the CGAS-STING signaling axis.
CC       {ECO:0000250|UniProtKB:A1L3C1}.
CC   -!- SUBUNIT: Interacts (via N-terminus) with RAB2B (in GTP-bound form).
CC       {ECO:0000250|UniProtKB:A1L3C1}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000250|UniProtKB:A1L3C1}.
CC   -!- SIMILARITY: Belongs to the GARIN family. {ECO:0000305}.
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DR   EMBL; BC109767; AAI09768.2; -; mRNA.
DR   RefSeq; NP_001192304.1; NM_001205375.2.
DR   AlphaFoldDB; Q32L49; -.
DR   STRING; 9913.ENSBTAP00000026757; -.
DR   PaxDb; Q32L49; -.
DR   GeneID; 617892; -.
DR   KEGG; bta:617892; -.
DR   CTD; 112703; -.
DR   eggNOG; ENOG502S585; Eukaryota.
DR   InParanoid; Q32L49; -.
DR   OrthoDB; 1443136at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
DR   GO; GO:0051607; P:defense response to virus; ISS:UniProtKB.
DR   GO; GO:0045087; P:innate immune response; ISS:UniProtKB.
DR   GO; GO:0032481; P:positive regulation of type I interferon production; ISS:UniProtKB.
DR   InterPro; IPR022168; DUF3699.
DR   Pfam; PF12480; DUF3699; 1.
PE   2: Evidence at transcript level;
KW   Golgi apparatus; Reference proteome.
FT   CHAIN           1..215
FT                   /note="Golgi associated RAB2 interactor protein 5A"
FT                   /id="PRO_0000334696"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          174..215
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        177..193
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   215 AA;  24228 MW;  C58660E5312EC070 CRC64;
     MKRGHEPKPA FGGAGEAGPG VMAERPLVPA CPTGRPGRLQ RHLLSGEFDQ LRDFRIFESN
     FVQVTRLGEV ANKVTMGVAA SSPALELPDL LLLAGPAKEN GHLQLFGLFP LQFVQLFVHD
     ESRWQLKVKF RTGRAFYLQL RAPPESRDRE FGQWVRLLYR LRFHSAQGAV PFTQDYSALE
     DDEDDDEDED RDLPAGELQA MEARLDPQMS ELWGL