GAR5A_MOUSE
ID GAR5A_MOUSE Reviewed; 212 AA.
AC A1L3C1; E9QKI6; Q0P5X9;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2012, sequence version 2.
DT 03-AUG-2022, entry version 79.
DE RecName: Full=Golgi associated RAB2 interactor protein 5A;
DE AltName: Full=Golgi associated RAB2B interactor-like 5 {ECO:0000303|PubMed:28930687};
DE Short=GARIL5 {ECO:0000303|PubMed:28930687};
GN Name=Garin5a; Synonyms=Fam71e1, Garil5 {ECO:0000303|PubMed:28930687};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP FUNCTION, INTERACTION WITH RAB2B, AND SUBCELLULAR LOCATION.
RX PubMed=28930687; DOI=10.1016/j.celrep.2017.08.085;
RA Takahama M., Fukuda M., Ohbayashi N., Kozaki T., Misawa T., Okamoto T.,
RA Matsuura Y., Akira S., Saitoh T.;
RT "The RAB2B-GARIL5 Complex Promotes Cytosolic DNA-Induced Innate Immune
RT Responses.";
RL Cell Rep. 20:2944-2954(2017).
CC -!- FUNCTION: RAB2B effector protein which promotes cytosolic DNA-induced
CC innate immune responses. Regulates IFN responses against DNA viruses by
CC regulating the CGAS-STING signaling axis.
CC {ECO:0000269|PubMed:28930687}.
CC -!- SUBUNIT: Interacts (via N-terminus) with RAB2B (in GTP-bound form).
CC {ECO:0000269|PubMed:28930687}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000269|PubMed:28930687}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=A1L3C1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A1L3C1-2; Sequence=VSP_033761;
CC -!- SIMILARITY: Belongs to the GARIN family. {ECO:0000305}.
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DR EMBL; AC149607; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC049752; AAH49752.1; -; mRNA.
DR EMBL; BC130017; AAI30018.1; -; mRNA.
DR CCDS; CCDS52232.1; -. [A1L3C1-1]
DR RefSeq; NP_082445.1; NM_028169.1. [A1L3C1-1]
DR RefSeq; XP_006541312.1; XM_006541249.1.
DR AlphaFoldDB; A1L3C1; -.
DR STRING; 10090.ENSMUSP00000103560; -.
DR PhosphoSitePlus; A1L3C1; -.
DR PaxDb; A1L3C1; -.
DR PRIDE; A1L3C1; -.
DR ProteomicsDB; 271837; -. [A1L3C1-1]
DR Antibodypedia; 68558; 1 antibodies from 1 providers.
DR Ensembl; ENSMUST00000107927; ENSMUSP00000103560; ENSMUSG00000051113. [A1L3C1-1]
DR GeneID; 75538; -.
DR KEGG; mmu:75538; -.
DR UCSC; uc009gpr.2; mouse. [A1L3C1-1]
DR CTD; 112703; -.
DR MGI; MGI:1922788; Fam71e1.
DR VEuPathDB; HostDB:ENSMUSG00000051113; -.
DR eggNOG; ENOG502S585; Eukaryota.
DR GeneTree; ENSGT00940000162319; -.
DR HOGENOM; CLU_100265_1_0_1; -.
DR InParanoid; A1L3C1; -.
DR OMA; HDESRCQ; -.
DR OrthoDB; 1443136at2759; -.
DR PhylomeDB; A1L3C1; -.
DR TreeFam; TF336050; -.
DR BioGRID-ORCS; 75538; 1 hit in 74 CRISPR screens.
DR ChiTaRS; Fam71e1; mouse.
DR PRO; PR:A1L3C1; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; A1L3C1; protein.
DR Bgee; ENSMUSG00000051113; Expressed in seminiferous tubule of testis and 77 other tissues.
DR ExpressionAtlas; A1L3C1; baseline and differential.
DR Genevisible; A1L3C1; MM.
DR GO; GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
DR GO; GO:0051607; P:defense response to virus; IDA:UniProtKB.
DR GO; GO:0045087; P:innate immune response; IDA:UniProtKB.
DR GO; GO:0032481; P:positive regulation of type I interferon production; IDA:UniProtKB.
DR InterPro; IPR022168; DUF3699.
DR Pfam; PF12480; DUF3699; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Golgi apparatus; Reference proteome.
FT CHAIN 1..212
FT /note="Golgi associated RAB2 interactor protein 5A"
FT /id="PRO_0000334698"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 162..212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 168..187
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..66
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_033761"
FT CONFLICT 138
FT /note="R -> L (in Ref. 2; AAI30018)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 212 AA; 24172 MW; F30567893EB433C5 CRC64;
MKGGRDLKAA RGGADRPLAP AYAPCRPGRL QRHLLSGEFD QLRDFPIFES NFVQVTRFGE
VANKVTMGVA ASSPALELPD LLLLAGPDKE NGHLQLLGLF PLQFVQLFVH DESRQQLKVK
FRTGRAFYLQ LRSPPETRDC EFGRWVRLLY RLRFHSPTCA VPFTHEDTAP EEEEEEEEEE
EEEEVKEGQL QPPEFQATEA RLDPQVSELW GL
