ID   GARA_MYCTO              Reviewed;         162 AA.
AC   P9WJA8; I3V6A5; P64897; Q50606;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 34.
DE   RecName: Full=Glycogen accumulation regulator GarA;
GN   Name=garA; OrderedLocusNames=MT1875;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Involved in regulation of glutamate metabolism.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- PTM: Phosphorylated on Thr-22 by PknB. Phosphorylated on Thr-21 by
CC       PknG. Phosphorylation at either Thr-21 or Thr-22 prevents binding to
CC       target enzymes (By similarity). {ECO:0000250}.
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DR   EMBL; AE000516; AAK46148.1; -; Genomic_DNA.
DR   PIR; D70721; D70721.
DR   RefSeq; WP_003899041.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WJA8; -.
DR   BMRB; P9WJA8; -.
DR   SMR; P9WJA8; -.
DR   EnsemblBacteria; AAK46148; AAK46148; MT1875.
DR   GeneID; 45425801; -.
DR   KEGG; mtc:MT1875; -.
DR   PATRIC; fig|83331.31.peg.2019; -.
DR   HOGENOM; CLU_108862_1_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   CDD; cd00060; FHA; 1.
DR   InterPro; IPR000253; FHA_dom.
DR   InterPro; IPR008984; SMAD_FHA_dom_sf.
DR   Pfam; PF00498; FHA; 1.
DR   SMART; SM00240; FHA; 1.
DR   SUPFAM; SSF49879; SSF49879; 1.
DR   PROSITE; PS50006; FHA_DOMAIN; 1.
PE   3: Inferred from homology;
KW   Phosphoprotein.
FT   CHAIN           1..162
FT                   /note="Glycogen accumulation regulator GarA"
FT                   /id="PRO_0000427862"
FT   DOMAIN          77..126
FT                   /note="FHA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00086"
FT   MOD_RES         21
FT                   /note="Phosphothreonine; by PknG"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         22
FT                   /note="Phosphothreonine; by PknB"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   162 AA;  17251 MW;  18B1C42151ED0CCA CRC64;
     MTDMNPDIEK DQTSDEVTVE TTSVFRADFL SELDAPAQAG TESAVSGVEG LPPGSALLVV
     KRGPNAGSRF LLDQAITSAG RHPDSDIFLD DVTVSRRHAE FRLENNEFNV VDVGSLNGTY
     VNREPVDSAV LANGDEVQIG KFRLVFLTGP KQGEDDGSTG GP