ID   GARE1_DANRE             Reviewed;         867 AA.
AC   Q7ZVU1;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=GRB2-associated and regulator of MAPK protein 1;
DE   AltName: Full=GRB2-associated and regulator of MAPK1;
GN   Name=garem1; Synonyms=fam59a, garem; ORFNames=zgc:55634;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Adapter protein that may provide a link between cell surface
CC       epidermal growth factor receptor and the MAPK/ERK signaling pathway.
CC       May promote cell proliferation (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the GAREM family. {ECO:0000305}.
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DR   EMBL; BC045411; AAH45411.1; -; mRNA.
DR   RefSeq; NP_956463.1; NM_200169.2.
DR   AlphaFoldDB; Q7ZVU1; -.
DR   SMR; Q7ZVU1; -.
DR   STRING; 7955.ENSDARP00000024393; -.
DR   PaxDb; Q7ZVU1; -.
DR   GeneID; 393138; -.
DR   KEGG; dre:393138; -.
DR   CTD; 393138; -.
DR   ZFIN; ZDB-GENE-040426-767; garem.
DR   eggNOG; ENOG502QRDN; Eukaryota.
DR   InParanoid; Q7ZVU1; -.
DR   OrthoDB; 288834at2759; -.
DR   PhylomeDB; Q7ZVU1; -.
DR   PRO; PR:Q7ZVU1; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0070064; F:proline-rich region binding; ISS:UniProtKB.
DR   GO; GO:0071364; P:cellular response to epidermal growth factor stimulus; ISS:UniProtKB.
DR   GO; GO:0007173; P:epidermal growth factor receptor signaling pathway; ISS:UniProtKB.
DR   GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; ISS:UniProtKB.
DR   GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; ISS:UniProtKB.
DR   Gene3D; 1.10.150.50; -; 1.
DR   InterPro; IPR025946; CABIT_dom.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   Pfam; PF12736; CABIT; 1.
DR   SUPFAM; SSF47769; SSF47769; 1.
PE   2: Evidence at transcript level;
KW   Mitogen; Phosphoprotein; Reference proteome.
FT   CHAIN           1..867
FT                   /note="GRB2-associated and regulator of MAPK protein 1"
FT                   /id="PRO_0000277649"
FT   DOMAIN          802..867
FT                   /note="SAM"
FT   REGION          12..322
FT                   /note="CABIT"
FT   REGION          511..530
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          536..594
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          735..758
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        544..580
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         464
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   867 AA;  95793 MW;  0E2677404CC48E34 CRC64;
     MDLGSMLYNS FNNITWSTTT LPLDRLISSY RLPQIVKLDS GESVEGLREN DYLLIHSCRQ
     WTTITAHSLE EGHYVIGPKI EIPVHYEGQF KLLEQDRDIK EPVQYYNSVE EVAKAFPERV
     YVMEEISFNF KMASGESNED TEVYNITLST GDELTLMGQA ELLYAKSSRE KSRFNTIFKR
     IGKLNSISKL GRGKMPCLIC MNHRTNESIS LPFQCRGRFS TCSQLELQMQ EGEHTIRTIV
     EKTRLPVNVM VPSSPPRNPH DLHLIREGHR YKLVNIQTKT VVVCCALRSN KILPVHFPLH
     VSTALPRLLV PEGLLQGESW FETVVHRWFT YCQEQFDIDD YSRAVRDVRV DWIEDGKSPK
     KSSAGGTGSG SAICNSSGSG SNGCPSHLHL PSSLSSARDE LTQSFHRLSV CVYGNNLHGN
     SEVNLQGCVS LCGDCAPAEP PDADYLFPEL QENSSGSLKS DVPYEELWLD HVKNAGPVLD
     HNEGVRGNSL SSGCTTALPY PKAGPTSALL SADVNLPPPP VPPKSEAVKE ECRLLDAPPI
     PPRSSKQAGS SSATVPYPSA KPRQKDTRSP SPTLSYYSSG LHSIGGEGES QIESDDQNHA
     CYPCSWIRPD ASESSKPLPC LNPSVNASFS RLSWPNDFCG ADSYKGEDFQ SLHCRSYSSY
     PRKRTPGTPK ACPSGLLDFD KRANFEGKAV SSKVQQVTQS AQFCTKSTSY NMDMCRDKPT
     DECITKQSQS CPILPPRTPK CTDAKKDAEA ATTDTADADA VELESKSCSP DGPHPGTTDV
     FSVSHPVATG LSWQPPSNLS GISIEEISKS LRFIGLSEDV VSLFVQEKID GNLLLQLTEE
     ILSEDFKLSK LQVKKLMQFI NGWRPKM