ID   GARE1_XENLA             Reviewed;         876 AA.
AC   Q6NRE4;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=GRB2-associated and regulator of MAPK protein;
DE   AltName: Full=GRB2-associated and regulator of MAPK1;
GN   Name=garem1; Synonyms=fam59a, garem;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Oocyte;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Adapter protein that may provide a link between cell surface
CC       epidermal growth factor receptor and the MAPK/ERK signaling pathway.
CC       May promote cell proliferation (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the GAREM family. {ECO:0000305}.
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DR   EMBL; BC070811; AAH70811.1; -; mRNA.
DR   RefSeq; NP_001084891.1; NM_001091422.1.
DR   AlphaFoldDB; Q6NRE4; -.
DR   SMR; Q6NRE4; -.
DR   PRIDE; Q6NRE4; -.
DR   DNASU; 431942; -.
DR   GeneID; 431942; -.
DR   KEGG; xla:431942; -.
DR   CTD; 431942; -.
DR   Xenbase; XB-GENE-976988; garem1.S.
DR   OMA; RESHRYK; -.
DR   OrthoDB; 288834at2759; -.
DR   Proteomes; UP000186698; Chromosome 6S.
DR   Bgee; 431942; Expressed in heart and 19 other tissues.
DR   GO; GO:0070064; F:proline-rich region binding; ISS:UniProtKB.
DR   GO; GO:0071364; P:cellular response to epidermal growth factor stimulus; ISS:UniProtKB.
DR   GO; GO:0007173; P:epidermal growth factor receptor signaling pathway; ISS:UniProtKB.
DR   GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; ISS:UniProtKB.
DR   GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; ISS:UniProtKB.
DR   Gene3D; 1.10.150.50; -; 1.
DR   InterPro; IPR025946; CABIT_dom.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   Pfam; PF12736; CABIT; 1.
DR   SUPFAM; SSF47769; SSF47769; 1.
PE   2: Evidence at transcript level;
KW   Mitogen; Phosphoprotein; Reference proteome.
FT   CHAIN           1..876
FT                   /note="GRB2-associated and regulator of MAPK protein"
FT                   /id="PRO_0000277650"
FT   DOMAIN          811..876
FT                   /note="SAM"
FT   REGION          9..318
FT                   /note="CABIT"
FT   REGION          460..569
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          708..741
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        462..503
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        534..548
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        552..569
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        708..722
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         451
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   876 AA;  97431 MW;  5687E46C5086C4CB CRC64;
     MELPVPSLKD VKWSSASFPL DLLVSSYRLP QLVRVDCAGE NVEGLRENDC LLIHSCRQWT
     TITAHSLEEG HYVIGPKIEI PVHYGGQFKL LEQDRDIKEP VQYFNSVEEV AKAFPERVYV
     MEEITFNVKV ASGECNEDTE VYNITLCTGD ELTLMGQAEI LYAKTSKEKS RLNTIFKKIG
     KLNSISKLGK GKMPCLICMN HRTNESISLP FQCKGRFSTR SPLEIQMQEG EHTIRNIVEK
     TRLPVNVTVP SPPPRNSYDL HFIREGHRYK FVNIQTKTVV VCFALHTNKI VPMHFPLHLS
     VPKFSLPENL IKGEVWQDSV VQHWYNICQE QFDIEEYSRA VRDVKADWSE ECKSPKKNWS
     AGHSHIPNSL SYARDELTQS FHRLSVCVYG NNLHGNSEVN LHGCRDLCGD WAAFPQDSPQ
     YQDSCDSGSD YLFSETSEEL TSLPAKPELP YEELWLEQGS VKRSGQPLTR SQSEKNKCDS
     FRGSLPSRCG TSSLPSPGAL LTTKSLDVSL PPPPVPPKSE AVKEECRLLN APPVPPRSSK
     PSSPTPSVPP AAENIVRQQT RSPSPTLSYY SSGLHSIGIT ESETTSSSDN SQVSCYPCNW
     MKNESSDLES NLTCGSASSE ALPSRLSWPN RYCGGAEGLN VNDLPMDQCR SYYSYPRQKT
     PGTPKKNSPA TFDFGGCGSF TGCNQGEFSD TVPGCPKSAS YSLESATDRM LGDNSTKQSL
     SCPALPPRAP KPSEGNALSE PLSLPMKIDG AEEEIQTCSP DFLEEHYLAK KGVQDIFSIS
     YPFSSPLHMQ LAPRSCGDGS PWQPPTDLSG LSVEEVSKSL RFIGLSEDVV SFFVSEKIDG
     NLLVQLTEEI LSEDFKLSKL QVKKLLQFIN GWRPKM