ID   GARL3_CHICK             Reviewed;         917 AA.
AC   Q5ZJY3;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=GTPase-activating Rap/Ran-GAP domain-like protein 3;
GN   Name=GARNL3; ORFNames=RCJMB04_14h1;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- SIMILARITY: Belongs to the GARNL3 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AJ720301; CAG31960.1; -; mRNA.
DR   RefSeq; NP_001025847.1; NM_001030676.2.
DR   AlphaFoldDB; Q5ZJY3; -.
DR   SMR; Q5ZJY3; -.
DR   STRING; 9031.ENSGALP00000001241; -.
DR   PaxDb; Q5ZJY3; -.
DR   PRIDE; Q5ZJY3; -.
DR   GeneID; 417087; -.
DR   KEGG; gga:417087; -.
DR   CTD; 84253; -.
DR   VEuPathDB; HostDB:geneid_417087; -.
DR   eggNOG; KOG3686; Eukaryota.
DR   InParanoid; Q5ZJY3; -.
DR   OrthoDB; 845465at2759; -.
DR   PhylomeDB; Q5ZJY3; -.
DR   PRO; PR:Q5ZJY3; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR   GO; GO:0090630; P:activation of GTPase activity; IBA:GO_Central.
DR   GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR   Gene3D; 3.40.50.11210; -; 1.
DR   InterPro; IPR001180; CNH_dom.
DR   InterPro; IPR035974; Rap/Ran-GAP_sf.
DR   InterPro; IPR000331; Rap/Ran_GAP_dom.
DR   Pfam; PF00780; CNH; 1.
DR   Pfam; PF02145; Rap_GAP; 1.
DR   SMART; SM00036; CNH; 1.
DR   SUPFAM; SSF111347; SSF111347; 1.
DR   PROSITE; PS50219; CNH; 1.
DR   PROSITE; PS50085; RAPGAP; 1.
PE   2: Evidence at transcript level;
KW   GTPase activation; Reference proteome.
FT   CHAIN           1..917
FT                   /note="GTPase-activating Rap/Ran-GAP domain-like protein 3"
FT                   /id="PRO_0000312217"
FT   DOMAIN          185..401
FT                   /note="Rap-GAP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00165"
FT   DOMAIN          483..792
FT                   /note="CNH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00795"
SQ   SEQUENCE   917 AA;  103770 MW;  E1BFB9CD0EFA6902 CRC64;
     MELSSAEAVS TRFLGLTQRS VSEDLGCRRG EFSRKHYGSV ELLISSDADG AIQRAGRFRV
     ENGSSDENTG YTPGTWHRTD VHLENPEYYT RWYFKYFLGK VHQNYIGTDS EKNPFFLSVV
     LSDQNNQRVP QYHSILWRKT GTQKICLPYS PTKTLSVKSI LSAMSLEKFE KGPREIFHPD
     IQKDLLVLEE QEGSVNFKFG VLYAKDGQLT DDEMFSNETG SESFQRFLHL LGDTITLKGW
     TGYRGGLDTK NDTTGTFSIY TVYQGHEIMF HVSTMLPYSR ENKQQVERKR HIGNDIVTIV
     FQEGEETAPA FKPSMIRSHF THIFALVRYN KQNDSYRLKI FSEESVPLFG PPLPSPPVFT
     NHQEFRDFVL VKLINGEKAT LETPTFSQKR QRTLDMLIRS LYQDLMPDLH KNMLNRRSFS
     DVLPDSPKST RKKEEARQAE FVRLGQALKL KTGVKGDAPT TLATTSFCKK EPWESQSFCS
     NFPHEVVCAD SWGQSLLVST DAGILLIDDG QTTVQVFDKT LQIKQMHVLE ALDYLIARTD
     KGKDSRLLVF RLSSVQKDIE TKQVIRSKYD CRENKLERTK GCHLYAINTH HSSELRIVVA
     IRNKLLLITK KYNPCNSLTG SSLSLSESPV EEFQYIREIC LSDPPVVMTL VDGPTGDSDN
     MICVAYRHQF DLVNESTGES YRLHHIEANK VNFVAAIDVY EDGEAGLLLC YNYVCQYRKV
     YPFNGGSPLI QPSAYDFHFS WNQVPYAVVC AFPYILAFTT DSIEIRLVVN GNLVHTAVVP
     ELQLVASRSD IYFKATAAVS GSSHSSSKEM SSRSSPQTPT AYDMLECSLS SSEGEVACKN
     LYKIPLSNLV GRSIERPLKS PLTPKVVTTP TSSGITSLPV THSPSLSRME IKEIANRTRK
     ELLGKLPLFF SVYISYH