GARL3_DANRE
ID GARL3_DANRE Reviewed; 1015 AA.
AC A5PF44;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 10-JUL-2007, sequence version 1.
DT 03-AUG-2022, entry version 79.
DE RecName: Full=GTPase-activating Rap/Ran-GAP domain-like protein 3;
GN Name=garnl3; ORFNames=si:dkey-46k8.1;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
CC -!- SIMILARITY: Belongs to the GARNL3 family. {ECO:0000305}.
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DR EMBL; AL929590; CAN88087.1; -; Genomic_DNA.
DR EMBL; BX005029; CAN88087.1; JOINED; Genomic_DNA.
DR EMBL; BX005029; CAN88090.1; -; Genomic_DNA.
DR EMBL; AL929590; CAN88090.1; JOINED; Genomic_DNA.
DR RefSeq; NP_001121999.1; NM_001128527.1.
DR AlphaFoldDB; A5PF44; -.
DR SMR; A5PF44; -.
DR STRING; 7955.ENSDARP00000080071; -.
DR PaxDb; A5PF44; -.
DR PRIDE; A5PF44; -.
DR Ensembl; ENSDART00000085636; ENSDARP00000080071; ENSDARG00000060631.
DR GeneID; 560594; -.
DR KEGG; dre:560594; -.
DR CTD; 84253; -.
DR ZFIN; ZDB-GENE-060526-61; garnl3.
DR eggNOG; KOG3686; Eukaryota.
DR GeneTree; ENSGT00940000159362; -.
DR HOGENOM; CLU_008685_1_0_1; -.
DR InParanoid; A5PF44; -.
DR OMA; FEGYSER; -.
DR OrthoDB; 845465at2759; -.
DR PhylomeDB; A5PF44; -.
DR PRO; PR:A5PF44; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 5.
DR Bgee; ENSDARG00000060631; Expressed in brain and 14 other tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR GO; GO:0090630; P:activation of GTPase activity; IBA:GO_Central.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 3.40.50.11210; -; 1.
DR InterPro; IPR001180; CNH_dom.
DR InterPro; IPR035974; Rap/Ran-GAP_sf.
DR InterPro; IPR000331; Rap/Ran_GAP_dom.
DR Pfam; PF00780; CNH; 1.
DR Pfam; PF02145; Rap_GAP; 1.
DR SMART; SM00036; CNH; 1.
DR SUPFAM; SSF111347; SSF111347; 1.
DR PROSITE; PS50219; CNH; 1.
DR PROSITE; PS50085; RAPGAP; 1.
PE 3: Inferred from homology;
KW GTPase activation; Reference proteome.
FT CHAIN 1..1015
FT /note="GTPase-activating Rap/Ran-GAP domain-like protein 3"
FT /id="PRO_0000312218"
FT DOMAIN 200..416
FT /note="Rap-GAP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00165"
FT DOMAIN 498..812
FT /note="CNH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00795"
FT REGION 821..842
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 924..1004
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 937..960
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1015 AA; 114144 MW; 99061FDE31B6EDEF CRC64;
MNSDINMYLG REKAGIMRKR ALLLRKGCSF EITSSASEDL GCRRGEFSRK HYGSVELLIS
SDADGAIQRA GRFRVENGSI DEISDYTPGT WRRTDVHLEN PEYHTRWYFK YFLGKVHQNY
VGTDAEKNPF FLSVVLSDQN NQRVPQYRAI LWRKTGTLKI SLPYSPTKTL SVKSILSAMN
VDRFEKGPRE ILNPEIQKDL LVLEEQEGSV NFKFGVLYAK DGQLTDDEMF SNEMGSETFE
KFLNLLGDTI CLQGWAGYRG GLDTKNDTTG INSIYTVYQG HELMFHVSTM LPYSKENKQQ
VERKRHIGND IVTIVFQEGD DASPSFKPSM IRSHFTHIFA LVRYNSQNDS YRLKIFSEES
VPLFGPPLPS PPVFTDHQEF RDFLLVKLIN GEKATLETPT FAQKRQRTLD MLIRSLYQDL
MPDMHKNMLN RRSFSDVLPE SPKSARKKEE ARQAEFVRVG QALKLKTIVR GDAPTSLVTT
GLCRKEPWES QSFCSSFPYD IVCGDSWGQS LLVATDSAGV MLLEDSPTLP PVQVFDKTLT
VKQMHVLEPQ DLLIARADKG KDARLYVYRL STLKQGIEER QLVRTKCDSR ENKLEKTKGC
HLYSINTHHG VELRIVAAIR NKLLLITRKQ SRLECVSSIA TVTGSTDSPV EEFQYIREIC
LCDSPVVMAL VDGPTGENDH MICVAYRHQF DLINESTGDA YRLHHVDSNR VNFVAAIDVY
EDGEAGLLLC YNNICVYKKV CPFNGATPMI QPNTSDFHFS WNQMPNATVC AFPYILAFTT
DSIEIRLVVN GNLVYTAVVP ELQLTASRSD IYFISSAPIN SASNCSSRDT SSQSSPQTPT
GYEMPVFPSP LGDGETQSKH IYKIPLSNLV GRSIERPLKS PLVNKVLTAP APSMTGPAPM
IGSTTSLSLS RMEIKEIASR TRKELLGLTE EPSSKADGNS VKQRRMSKKN KEEEQKRTAE
ISIAEQVGME SVDGETDIQQ LCPSGSEVEV RDDSPPTANP FTFSTSFEDD ILDLK
