ID   GAS1_CAEEL              Reviewed;         228 AA.
AC   Q09553;
DT   16-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2003, sequence version 2.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=Growth arrest-specific protein 1 homolog;
DE   AltName: Full=Pharynx-associated gas1 homolog;
DE   Flags: Precursor;
GN   Name=phg-1; Synonyms=phas-1; ORFNames=F27E5.4;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000312|EMBL:CAA88466.2};
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE
RP   SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX   PubMed=11955608; DOI=10.1016/s0167-4781(01)00321-9;
RA   Agostoni E., Gobessi S., Petrini E., Monte M., Schneider C.;
RT   "Cloning and characterization of the C. elegans gas1 homolog: phas-1.";
RL   Biochim. Biophys. Acta 1574:1-9(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Role in pharynx function or development.
CC       {ECO:0000269|PubMed:11955608}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11955608};
CC       Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:11955608}. Note=Localized
CC       on the muscle cell plasma membrane.
CC   -!- TISSUE SPECIFICITY: Pharynx muscle cells from its early formation, in
CC       the two-fold embryo, until the adult stage.
CC       {ECO:0000269|PubMed:11955608}.
CC   -!- DEVELOPMENTAL STAGE: All developmental stages, but not dauer larva.
CC       {ECO:0000269|PubMed:11955608}.
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DR   EMBL; Z48582; CAA88466.2; -; Genomic_DNA.
DR   PIR; T21458; T21458.
DR   RefSeq; NP_496186.2; NM_063785.4.
DR   AlphaFoldDB; Q09553; -.
DR   SMR; Q09553; -.
DR   STRING; 6239.F27E5.4; -.
DR   EPD; Q09553; -.
DR   PaxDb; Q09553; -.
DR   PeptideAtlas; Q09553; -.
DR   EnsemblMetazoa; F27E5.4.1; F27E5.4.1; WBGene00004017.
DR   GeneID; 185024; -.
DR   KEGG; cel:CELE_F27E5.4; -.
DR   UCSC; F27E5.4; c. elegans.
DR   CTD; 185024; -.
DR   WormBase; F27E5.4; CE30964; WBGene00004017; phg-1.
DR   eggNOG; ENOG502S2DN; Eukaryota.
DR   HOGENOM; CLU_1215702_0_0_1; -.
DR   InParanoid; Q09553; -.
DR   OMA; QRCTESC; -.
DR   OrthoDB; 1200671at2759; -.
DR   PhylomeDB; Q09553; -.
DR   PRO; PR:Q09553; -.
DR   Proteomes; UP000001940; Chromosome II.
DR   Bgee; WBGene00004017; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR   GO; GO:0046658; C:anchored component of plasma membrane; IDA:UniProtKB.
DR   GO; GO:1902807; P:negative regulation of cell cycle G1/S phase transition; IMP:UniProtKB.
DR   InterPro; IPR016017; GDNF/GAS1.
DR   Pfam; PF02351; GDNF; 1.
DR   SMART; SM00907; GDNF; 2.
PE   2: Evidence at transcript level;
KW   Cell membrane; Developmental protein; Glycoprotein; GPI-anchor;
KW   Lipoprotein; Membrane; Reference proteome; Signal.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000255"
FT   CHAIN           18..205
FT                   /note="Growth arrest-specific protein 1 homolog"
FT                   /id="PRO_0000021316"
FT   PROPEP          206..228
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000021317"
FT   LIPID           205
FT                   /note="GPI-anchor amidated aspartate"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        143
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        156
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   228 AA;  24345 MW;  061933FB807476A1 CRC64;
     MRRVILPLVM TVTLCLAQEA SEACTKALTD CENDLECQNR LAPLMAACST NTCQPQCRSA
     VLNVYQNKLG RILLRSDATC IPGRDELRTC NFLPAESTVH CSLGKLACEG DLQCNSKFGV
     FMSECEADAA RGACTDKCKT LLNQTIETSV GSVFSNCTCT ARDDQLCTNL KDNLLGVCLK
     NTPGVTLSPS DNSITDAPGG NDLADSSVGH GFNILSAISV YLLTVLVF