GAS1_MOUSE
ID GAS1_MOUSE Reviewed; 343 AA.
AC Q01721;
DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT 16-MAY-2003, sequence version 2.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Growth arrest-specific protein 1;
DE Short=GAS-1;
DE Flags: Precursor;
GN Name=Gas1; Synonyms=Gas-1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RX PubMed=1505026; DOI=10.1016/0092-8674(92)90429-g;
RA del Sal G., Ruaro M.E., Philipson L., Schneider C.;
RT "The growth arrest-specific gene, gas1, is involved in growth
RT suppression.";
RL Cell 70:595-607(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Specific growth arrest protein involved in growth
CC suppression. Blocks entry to S phase. Prevents cycling of normal and
CC transformed cells. {ECO:0000269|PubMed:1505026}.
CC -!- INTERACTION:
CC Q01721; Q6AZB0: Boc; NbExp=2; IntAct=EBI-15729104, EBI-15610126;
CC Q01721; Q32MD9: Cdon; NbExp=3; IntAct=EBI-15729104, EBI-7017034;
CC Q01721; Q9BWV1: BOC; Xeno; NbExp=2; IntAct=EBI-15729104, EBI-718555;
CC Q01721; O35158: Cdon; Xeno; NbExp=4; IntAct=EBI-15729104, EBI-7016767;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor, GPI-
CC anchor {ECO:0000250}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA46256.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; X65128; CAA46256.1; ALT_INIT; mRNA.
DR EMBL; BC058628; AAH58628.1; -; mRNA.
DR PIR; S25771; S25771.
DR RefSeq; NP_032112.1; NM_008086.2.
DR AlphaFoldDB; Q01721; -.
DR SMR; Q01721; -.
DR BioGRID; 199832; 1.
DR DIP; DIP-59801N; -.
DR IntAct; Q01721; 5.
DR STRING; 10090.ENSMUSP00000064555; -.
DR GlyGen; Q01721; 2 sites.
DR iPTMnet; Q01721; -.
DR PhosphoSitePlus; Q01721; -.
DR CPTAC; non-CPTAC-3465; -.
DR MaxQB; Q01721; -.
DR PaxDb; Q01721; -.
DR PeptideAtlas; Q01721; -.
DR PRIDE; Q01721; -.
DR ProteomicsDB; 267561; -.
DR Antibodypedia; 13350; 253 antibodies from 31 providers.
DR DNASU; 14451; -.
DR Ensembl; ENSMUST00000065086; ENSMUSP00000064555; ENSMUSG00000052957.
DR GeneID; 14451; -.
DR KEGG; mmu:14451; -.
DR UCSC; uc007qvi.2; mouse.
DR CTD; 2619; -.
DR MGI; MGI:95655; Gas1.
DR VEuPathDB; HostDB:ENSMUSG00000052957; -.
DR eggNOG; ENOG502QSF7; Eukaryota.
DR GeneTree; ENSGT00390000001195; -.
DR InParanoid; Q01721; -.
DR OMA; TAGDSQY; -.
DR OrthoDB; 1101441at2759; -.
DR PhylomeDB; Q01721; -.
DR TreeFam; TF329660; -.
DR Reactome; R-MMU-5632681; Ligand-receptor interactions.
DR Reactome; R-MMU-5635838; Activation of SMO.
DR BioGRID-ORCS; 14451; 5 hits in 75 CRISPR screens.
DR ChiTaRS; Gas1; mouse.
DR PRO; PR:Q01721; -.
DR Proteomes; UP000000589; Chromosome 13.
DR RNAct; Q01721; protein.
DR Bgee; ENSMUSG00000052957; Expressed in ciliary body and 305 other tissues.
DR ExpressionAtlas; Q01721; baseline and differential.
DR GO; GO:0046658; C:anchored component of plasma membrane; IDA:UniProtKB.
DR GO; GO:0016020; C:membrane; IDA:MGI.
DR GO; GO:0005886; C:plasma membrane; IDA:MGI.
DR GO; GO:0006915; P:apoptotic process; IMP:MGI.
DR GO; GO:0007411; P:axon guidance; IMP:MGI.
DR GO; GO:0043010; P:camera-type eye development; IMP:MGI.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0045165; P:cell fate commitment; IMP:MGI.
DR GO; GO:0008283; P:cell population proliferation; IMP:MGI.
DR GO; GO:0021587; P:cerebellum morphogenesis; IMP:MGI.
DR GO; GO:0048589; P:developmental growth; IMP:MGI.
DR GO; GO:0021904; P:dorsal/ventral neural tube patterning; IMP:MGI.
DR GO; GO:0009953; P:dorsal/ventral pattern formation; IMP:MGI.
DR GO; GO:0048701; P:embryonic cranial skeleton morphogenesis; IMP:MGI.
DR GO; GO:0042733; P:embryonic digit morphogenesis; IMP:MGI.
DR GO; GO:0048598; P:embryonic morphogenesis; IMP:MGI.
DR GO; GO:0048706; P:embryonic skeletal system development; IMP:MGI.
DR GO; GO:0048592; P:eye morphogenesis; IMP:MGI.
DR GO; GO:0042474; P:middle ear morphogenesis; IMP:MGI.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IDA:UniProtKB.
DR GO; GO:1902807; P:negative regulation of cell cycle G1/S phase transition; NAS:UniProtKB.
DR GO; GO:0030308; P:negative regulation of cell growth; IDA:UniProtKB.
DR GO; GO:0050680; P:negative regulation of epithelial cell proliferation; IMP:MGI.
DR GO; GO:2001240; P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; IDA:MGI.
DR GO; GO:0045930; P:negative regulation of mitotic cell cycle; ISS:UniProtKB.
DR GO; GO:0010955; P:negative regulation of protein processing; ISS:UniProtKB.
DR GO; GO:0045879; P:negative regulation of smoothened signaling pathway; IDA:MGI.
DR GO; GO:0042476; P:odontogenesis; IMP:UniProtKB.
DR GO; GO:0042473; P:outer ear morphogenesis; IMP:MGI.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IMP:MGI.
DR GO; GO:0050679; P:positive regulation of epithelial cell proliferation; IMP:MGI.
DR GO; GO:0002053; P:positive regulation of mesenchymal cell proliferation; IMP:MGI.
DR GO; GO:0045880; P:positive regulation of smoothened signaling pathway; IDA:MGI.
DR GO; GO:0012501; P:programmed cell death; IDA:MGI.
DR GO; GO:0051726; P:regulation of cell cycle; TAS:MGI.
DR GO; GO:0060628; P:regulation of ER to Golgi vesicle-mediated transport; ISS:UniProtKB.
DR GO; GO:0008589; P:regulation of smoothened signaling pathway; IMP:UniProtKB.
DR GO; GO:0060021; P:roof of mouth development; IMP:MGI.
DR GO; GO:0007224; P:smoothened signaling pathway; IMP:MGI.
DR InterPro; IPR039596; GAS1.
DR InterPro; IPR016017; GDNF/GAS1.
DR PANTHER; PTHR16840; PTHR16840; 1.
DR Pfam; PF02351; GDNF; 1.
DR SMART; SM00907; GDNF; 2.
PE 1: Evidence at protein level;
KW Cell cycle; Cell membrane; Glycoprotein; GPI-anchor; Growth arrest;
KW Lipoprotein; Membrane; Reference proteome; Signal.
FT SIGNAL 1..38
FT /evidence="ECO:0000255"
FT CHAIN 39..315
FT /note="Growth arrest-specific protein 1"
FT /id="PRO_0000021320"
FT PROPEP 316..343
FT /note="Removed in mature form"
FT /evidence="ECO:0000255"
FT /id="PRO_0000021321"
FT REGION 268..317
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT LIPID 315
FT /note="GPI-anchor amidated serine"
FT /evidence="ECO:0000255"
FT CARBOHYD 114
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 321
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 343 AA; 35694 MW; F85D393F248B8895 CRC64;
MLAALLGGAG ARTGTLPGAL LCLMALLQLL CSAPRGSGLA HGRRLICWQA LLQCQGEPDC
SYAYSQYAEA CAPVLAQRGG ADAPGPAGAF PASAASSPRW RCPSHCISAL IQLNHTRRGP
ALEDCDCAQD EHCRSTKRAI EPCLPRTSSV GPGAGAGSVM GCTEARRRCD RDSRCNLALS
RYLAYCGKLF NGLRCTDECR AVIEDMLAVP KAALLNDCVC DGLERPICES VKENMARLCF
GPDASNGPGS SGSDGGLDDY YDEEYDDEQR AGAAGGEQPL DDDDGLARPG GGAAAAGGRG
DLPHGPGRRS SSSGSGGHWA NRSAWTPFAC LLLLLLLLLG SHL
