GAS7_HUMAN
ID GAS7_HUMAN Reviewed; 476 AA.
AC O60861; A8KAC2; B2RCK9; O43144; Q53Y77; Q7Z571;
DT 11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT 16-DEC-2008, sequence version 3.
DT 03-AUG-2022, entry version 197.
DE RecName: Full=Growth arrest-specific protein 7;
DE Short=GAS-7;
GN Name=GAS7; Synonyms=KIAA0394;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RC TISSUE=Cerebellum;
RA Chao C.C.-K., Kuo J.T., Ju Y.-T., Lin-Chao S.;
RT "Human gas7: conservation of a mammalian growth-arrest-specific gene.";
RL Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4).
RC TISSUE=Brain;
RX PubMed=9455477; DOI=10.1093/dnares/4.5.307;
RA Ishikawa K., Nagase T., Nakajima D., Seki N., Ohira M., Miyajima N.,
RA Tanaka A., Kotani H., Nomura N., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. VIII. 78
RT new cDNA clones from brain which code for large proteins in vitro.";
RL DNA Res. 4:307-313(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RA Shan Y.X., Yu L.;
RL Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA Phelan M., Farmer A.;
RT "Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4).
RC TISSUE=Thalamus, and Trachea;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Eye, and Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [9]
RP PARTIAL NUCLEOTIDE SEQUENCE [MRNA], AND CHROMOSOMAL TRANSLOCATION WITH
RP KMT2A/MLL1.
RX PubMed=10706619; DOI=10.1073/pnas.050397097;
RA Megonigal M.D., Cheung N.-K.V., Rappaport E.F., Nowell P.C., Wilson R.B.,
RA Jones D.H., Addya K., Leonard D.G.B., Kushner B.H., Williams T.M.,
RA Lange B.J., Felix C.A.;
RT "Detection of leukemia-associated MLL-GAS7 translocation early during
RT chemotherapy with DNA topoisomerase II inhibitors.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:2814-2819(2000).
RN [10]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-117, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [11]
RP STRUCTURE BY NMR OF 79-111.
RG RIKEN structural genomics initiative (RSGI);
RT "Solution structure of the WW domain from the human growth-arrest-specific
RT protein 7, GAS-7.";
RL Submitted (OCT-2007) to the PDB data bank.
CC -!- FUNCTION: May play a role in promoting maturation and morphological
CC differentiation of cerebellar neurons.
CC -!- INTERACTION:
CC O60861; Q96HA8: NTAQ1; NbExp=4; IntAct=EBI-2683717, EBI-741158;
CC O60861-1; Q16543: CDC37; NbExp=3; IntAct=EBI-11745923, EBI-295634;
CC O60861-1; O60861-1: GAS7; NbExp=3; IntAct=EBI-11745923, EBI-11745923;
CC O60861-1; Q9Y4Z0: LSM4; NbExp=3; IntAct=EBI-11745923, EBI-372521;
CC O60861-1; Q96EZ8: MCRS1; NbExp=3; IntAct=EBI-11745923, EBI-348259;
CC O60861-1; Q9NZQ3-3: NCKIPSD; NbExp=5; IntAct=EBI-11745923, EBI-10963850;
CC O60861-1; Q96HA8: NTAQ1; NbExp=5; IntAct=EBI-11745923, EBI-741158;
CC O60861-1; O95070: YIF1A; NbExp=3; IntAct=EBI-11745923, EBI-2799703;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=3;
CC IsoId=O60861-3; Sequence=Displayed;
CC Name=1;
CC IsoId=O60861-1; Sequence=VSP_035988;
CC Name=2; Synonyms=GAS7-CB;
CC IsoId=O60861-2; Sequence=VSP_006802, VSP_006803;
CC Name=4;
CC IsoId=O60861-4; Sequence=VSP_044294, VSP_044295;
CC -!- DISEASE: Note=A chromosomal aberration involving GAS7 is found in acute
CC myeloid leukemia. Translocation t(11;17)(q23;p13) with KMT2A/MLL1.
CC {ECO:0000269|PubMed:10706619}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA23690.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and
CC Haematology;
CC URL="http://atlasgeneticsoncology.org/Genes/GAS7ID257.html";
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DR EMBL; AJ224876; CAA12177.1; -; mRNA.
DR EMBL; AB007854; BAA23690.2; ALT_INIT; mRNA.
DR EMBL; AY327406; AAP92798.1; -; mRNA.
DR EMBL; BT006891; AAP35537.1; -; mRNA.
DR EMBL; AK292987; BAF85676.1; -; mRNA.
DR EMBL; AK315162; BAG37606.1; -; mRNA.
DR EMBL; AC000003; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC005747; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC026591; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC083783; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC107938; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471108; EAW90013.1; -; Genomic_DNA.
DR EMBL; CH471108; EAW90011.1; -; Genomic_DNA.
DR EMBL; CH471108; EAW90012.1; -; Genomic_DNA.
DR EMBL; BC001152; AAH01152.1; -; mRNA.
DR EMBL; BC006454; AAH06454.2; -; mRNA.
DR EMBL; AF231998; AAG26332.2; ALT_SEQ; mRNA.
DR CCDS; CCDS11152.1; -. [O60861-3]
DR CCDS; CCDS42263.1; -. [O60861-4]
DR CCDS; CCDS45611.1; -. [O60861-2]
DR CCDS; CCDS58518.1; -. [O60861-1]
DR RefSeq; NP_001124303.1; NM_001130831.1. [O60861-1]
DR RefSeq; NP_003635.2; NM_003644.2. [O60861-2]
DR RefSeq; NP_958836.1; NM_201432.1. [O60861-4]
DR RefSeq; NP_958839.1; NM_201433.1. [O60861-3]
DR RefSeq; XP_005256888.1; XM_005256831.3. [O60861-1]
DR RefSeq; XP_005256889.1; XM_005256832.3. [O60861-1]
DR RefSeq; XP_011522346.1; XM_011524044.2. [O60861-1]
DR RefSeq; XP_016880728.1; XM_017025239.1. [O60861-1]
DR PDB; 2LX7; NMR; -; A=1-60.
DR PDB; 2YSH; NMR; -; A=79-111.
DR PDBsum; 2LX7; -.
DR PDBsum; 2YSH; -.
DR AlphaFoldDB; O60861; -.
DR BMRB; O60861; -.
DR SMR; O60861; -.
DR BioGRID; 114094; 30.
DR IntAct; O60861; 22.
DR MINT; O60861; -.
DR STRING; 9606.ENSP00000407552; -.
DR iPTMnet; O60861; -.
DR PhosphoSitePlus; O60861; -.
DR BioMuta; GAS7; -.
DR jPOST; O60861; -.
DR MassIVE; O60861; -.
DR MaxQB; O60861; -.
DR PaxDb; O60861; -.
DR PeptideAtlas; O60861; -.
DR PRIDE; O60861; -.
DR ProteomicsDB; 1898; -.
DR ProteomicsDB; 49633; -. [O60861-3]
DR ProteomicsDB; 49634; -. [O60861-1]
DR ProteomicsDB; 49635; -. [O60861-2]
DR Antibodypedia; 24803; 449 antibodies from 30 providers.
DR DNASU; 8522; -.
DR Ensembl; ENST00000323816.8; ENSP00000322608.5; ENSG00000007237.19. [O60861-4]
DR Ensembl; ENST00000432992.7; ENSP00000407552.2; ENSG00000007237.19. [O60861-3]
DR Ensembl; ENST00000437099.6; ENSP00000410108.2; ENSG00000007237.19. [O60861-1]
DR Ensembl; ENST00000542249.5; ENSP00000443265.2; ENSG00000007237.19. [O60861-1]
DR Ensembl; ENST00000579158.5; ENSP00000463527.2; ENSG00000007237.19. [O60861-1]
DR Ensembl; ENST00000580865.5; ENSP00000463873.1; ENSG00000007237.19. [O60861-2]
DR Ensembl; ENST00000585266.5; ENSP00000464240.2; ENSG00000007237.19. [O60861-4]
DR GeneID; 8522; -.
DR KEGG; hsa:8522; -.
DR MANE-Select; ENST00000432992.7; ENSP00000407552.2; NM_201433.2; NP_958839.1.
DR UCSC; uc002gmg.2; human. [O60861-3]
DR CTD; 8522; -.
DR DisGeNET; 8522; -.
DR GeneCards; GAS7; -.
DR HGNC; HGNC:4169; GAS7.
DR HPA; ENSG00000007237; Tissue enhanced (brain).
DR MIM; 603127; gene.
DR neXtProt; NX_O60861; -.
DR OpenTargets; ENSG00000007237; -.
DR PharmGKB; PA28583; -.
DR VEuPathDB; HostDB:ENSG00000007237; -.
DR eggNOG; KOG0940; Eukaryota.
DR eggNOG; KOG2398; Eukaryota.
DR GeneTree; ENSGT00940000156268; -.
DR HOGENOM; CLU_052182_0_1_1; -.
DR InParanoid; O60861; -.
DR OMA; NAETTWE; -.
DR OrthoDB; 530520at2759; -.
DR PhylomeDB; O60861; -.
DR TreeFam; TF328986; -.
DR PathwayCommons; O60861; -.
DR SignaLink; O60861; -.
DR SIGNOR; O60861; -.
DR BioGRID-ORCS; 8522; 11 hits in 1077 CRISPR screens.
DR ChiTaRS; GAS7; human.
DR EvolutionaryTrace; O60861; -.
DR GeneWiki; GAS7; -.
DR GenomeRNAi; 8522; -.
DR Pharos; O60861; Tbio.
DR PRO; PR:O60861; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; O60861; protein.
DR Bgee; ENSG00000007237; Expressed in cerebellar vermis and 209 other tissues.
DR ExpressionAtlas; O60861; baseline and differential.
DR Genevisible; O60861; HS.
DR GO; GO:0005884; C:actin filament; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR GO; GO:0030041; P:actin filament polymerization; IBA:GO_Central.
DR GO; GO:0048812; P:neuron projection morphogenesis; IBA:GO_Central.
DR CDD; cd07649; F-BAR_GAS7; 1.
DR Gene3D; 1.20.1270.60; -; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR001060; FCH_dom.
DR InterPro; IPR037957; GAS7_F-BAR.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR Pfam; PF00611; FCH; 1.
DR Pfam; PF14604; SH3_9; 1.
DR Pfam; PF00397; WW; 1.
DR SMART; SM00055; FCH; 1.
DR SMART; SM00326; SH3; 1.
DR SMART; SM00456; WW; 1.
DR SUPFAM; SSF103657; SSF103657; 1.
DR SUPFAM; SSF50044; SSF50044; 1.
DR SUPFAM; SSF51045; SSF51045; 1.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS50002; SH3; 1.
DR PROSITE; PS01159; WW_DOMAIN_1; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Chromosomal rearrangement; Coiled coil;
KW Cytoplasm; Developmental protein; Differentiation; Neurogenesis;
KW Phosphoprotein; Proto-oncogene; Reference proteome; SH3 domain.
FT CHAIN 1..476
FT /note="Growth arrest-specific protein 7"
FT /id="PRO_0000076057"
FT DOMAIN 1..62
FT /note="SH3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT DOMAIN 77..110
FT /note="WW"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00224"
FT DOMAIN 196..456
FT /note="F-BAR"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01077"
FT REGION 100..171
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 309..419
FT /evidence="ECO:0000255"
FT COMPBIAS 100..131
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 149..171
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 117
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19690332"
FT MOD_RES 163
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q60780"
FT VAR_SEQ 1..140
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039, ECO:0000303|Ref.1"
FT /id="VSP_006802"
FT VAR_SEQ 1..64
FT /note="Missing (in isoform 1)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:9455477, ECO:0000303|Ref.4"
FT /id="VSP_035988"
FT VAR_SEQ 1..60
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:9455477"
FT /id="VSP_044294"
FT VAR_SEQ 61
FT /note="E -> M (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:9455477"
FT /id="VSP_044295"
FT VAR_SEQ 141..156
FT /note="PPETAHMSVRKSTGDS -> MSNMENSFDDVSCLSP (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039, ECO:0000303|Ref.1"
FT /id="VSP_006803"
FT CONFLICT 301
FT /note="E -> D (in Ref. 1; CAA12177)"
FT /evidence="ECO:0000305"
FT STRAND 5..9
FT /evidence="ECO:0007829|PDB:2LX7"
FT STRAND 28..32
FT /evidence="ECO:0007829|PDB:2LX7"
FT STRAND 40..43
FT /evidence="ECO:0007829|PDB:2LX7"
FT STRAND 49..52
FT /evidence="ECO:0007829|PDB:2LX7"
FT HELIX 54..56
FT /evidence="ECO:0007829|PDB:2LX7"
FT STRAND 57..59
FT /evidence="ECO:0007829|PDB:2LX7"
FT STRAND 84..87
FT /evidence="ECO:0007829|PDB:2YSH"
FT STRAND 93..96
FT /evidence="ECO:0007829|PDB:2YSH"
FT STRAND 98..100
FT /evidence="ECO:0007829|PDB:2YSH"
FT STRAND 103..107
FT /evidence="ECO:0007829|PDB:2YSH"
SQ SEQUENCE 476 AA; 54371 MW; 57BFB99907652745 CRC64;
MSGARCRTLY PFSGERHGQG LRFAAGELIT LLQVPDGGWW EGEKEDGLRG WFPASYVQLL
EKPGMVPPPP GEESQTVILP PGWQSYLSPQ GRRYYVNTTT NETTWERPSS SPGIPASPGS
HRSSLPPTVN GYHASGTPAH PPETAHMSVR KSTGDSQNLG SSSPSKKQSK ENTITINCVT
FPHPDTMPEQ QLLKPTEWSY CDYFWADKKD PQGNGTVAGF ELLLQKQLKG KQMQKEMSEF
IRERIKIEED YAKNLAKLSQ NSLASQEEGS LGEAWAQVKK SLADEAEVHL KFSAKLHSEV
EKPLMNFREN FKKDMKKCDH HIADLRKQLA SRYASVEKAR KALTERQRDL EMKTQQLEIK
LSNKTEEDIK KARRKSTQAG DDLMRCVDLY NQAQSKWFEE MVTTTLELER LEVERVEMIR
QHLCQYTQLR HETDMFNQST VEPVDQLLRK VDPAKDRELW VREHKTGNIR PVDMEI
