ID   GASP2_PONAB             Reviewed;         838 AA.
AC   Q5R7U0;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=G-protein coupled receptor-associated sorting protein 2;
DE            Short=GASP-2;
GN   Name=GPRASP2;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in regulation of a variety of G-protein
CC       coupled receptors. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with cytoplasmic tails of a variety of G protein-
CC       coupled receptors such as muscarinic acetylcholine receptor M1/CHRM1
CC       and calcitonin receptor/CALCR. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the GPRASP family. {ECO:0000305}.
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DR   EMBL; CR860019; CAH92170.1; -; mRNA.
DR   RefSeq; NP_001126271.1; NM_001132799.1.
DR   RefSeq; XP_009233350.1; XM_009235075.1.
DR   AlphaFoldDB; Q5R7U0; -.
DR   SMR; Q5R7U0; -.
DR   STRING; 9601.ENSPPYP00000023025; -.
DR   Ensembl; ENSPPYT00000023994; ENSPPYP00000023025; ENSPPYG00000020569.
DR   Ensembl; ENSPPYT00000047281; ENSPPYP00000043869; ENSPPYG00000020569.
DR   GeneID; 100173243; -.
DR   KEGG; pon:100173243; -.
DR   CTD; 114928; -.
DR   eggNOG; ENOG502S6CE; Eukaryota.
DR   GeneTree; ENSGT00940000162726; -.
DR   HOGENOM; CLU_017437_0_0_1; -.
DR   InParanoid; Q5R7U0; -.
DR   OMA; WPREEAN; -.
DR   OrthoDB; 860703at2759; -.
DR   TreeFam; TF335652; -.
DR   Proteomes; UP000001595; Chromosome X.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR006911; ARM-rpt_dom.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR043374; BHLHb9/GASP-1/GASP-2.
DR   PANTHER; PTHR46414; PTHR46414; 1.
DR   Pfam; PF04826; Arm_2; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   2: Evidence at transcript level;
KW   Phosphoprotein; Reference proteome.
FT   CHAIN           1..838
FT                   /note="G-protein coupled receptor-associated sorting
FT                   protein 2"
FT                   /id="PRO_0000239055"
FT   REGION          1..121
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          218..293
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          531..552
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        10..35
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        223..241
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        244..258
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         282
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8BUY8"
FT   MOD_RES         284
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8BUY8"
SQ   SEQUENCE   838 AA;  93728 MW;  EC91F94A2174E66F CRC64;
     MTGAEIEPSA QAKPEKKAGE EVVAGPEREN DVPLVVRPKV RTQATTGARP KTETKSVPAA
     RPKTEAQAMS GARPKTEAQV MGGARPKTEA QGMAGARPKT DARAVGGARS KTDAKAIPGA
     RPEDEAQAWA QSEFGTEAVS QAEGVSQTNA VAWPLATAES GSVTKSKGLS MDRELVNVDA
     ETFPGTQGQK GIQPWFGPGE ETNMGSWCYS RPRAREEASN ESGFWSADET STASSFWAGE
     ETSVRSWPRE ESNTRSRHRA KHQTNPRSRP RSKQEAYVDS WSGSEDEAGN PFSFWAGENT
     NNLFRPRVRE EANIRSKLRT NREDCFESES EDEFYKQSWV LPGEEADSRF RHRDKEDPNT
     ALKLRAQKDV DSDRVKQEPR FEEEVIIGSW FWAEKETSLE GGASAICESE PGTEEGAIGG
     SAYWAEEKSS LGAVAREEAK PESEEEAIFG SWFWDRDEAC FDLNPCPVYK VSDRFRDAAE
     ELNASSRPQT WDEVTVEFKP GLFHGVGFRS TSPFRIPEEA SEMLEAKPKN LELSPEGEEQ
     ESLLQPDQPS PEFTFQYDPS YRSVREIREH LRARESAESE SWSCSCIQCE LKIGSEEFEE
     LLLLMDKIRD PFIHEISKIA MGMRSASQFT RDFIRDSGVV SLIETLLNYP SSRVRTSFLE
     NMIHMAPPYP NLNMIETFIC QVCEETLAHS VDSLEQLTGI RMLRHLTMTI DYHTLIANYM
     SGFLSLLTTA NARTKFHVLK MLLNLSENPA VAKKLFSAKA LSIFVGLFNI EETNDNIQIV
     IKMFQNISNI IKSGKMSLID DDFSLEPLIS AFREFEELAK QLQAQIDNQN DPEVGQQS