GASR_BOVIN
ID GASR_BOVIN Reviewed; 454 AA.
AC P79266; Q2KI20;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1997, sequence version 1.
DT 25-MAY-2022, entry version 132.
DE RecName: Full=Gastrin/cholecystokinin type B receptor;
DE Short=CCK-B receptor;
DE Short=CCK-BR;
DE AltName: Full=Cholecystokinin-2 receptor;
DE Short=CCK2-R;
GN Name=CCKBR;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Pancreas;
RX PubMed=8851180; DOI=10.1016/0014-2999(95)00737-7;
RA Dufresne M., Escrieut C., Clerc P., le Huerou-Luron I., Prats H.,
RA Bertrand V., le Meuth V., Guilloteau P., Vaysse N., Fourmy D.;
RT "Molecular cloning, developmental expression and pharmacological
RT characterization of the CCKB/gastrin receptor in the calf pancreas.";
RL Eur. J. Pharmacol. 297:165-179(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Hypothalamus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Receptor for gastrin and cholecystokinin. The CCK-B receptors
CC occur throughout the central nervous system where they modulate
CC anxiety, analgesia, arousal, and neuroleptic activity. This receptor
CC mediates its action by association with G proteins that activate a
CC phosphatidylinositol-calcium second messenger system.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; S83090; AAB46896.1; -; mRNA.
DR EMBL; BC112800; AAI12801.1; -; mRNA.
DR RefSeq; NP_776687.2; NM_174262.3.
DR AlphaFoldDB; P79266; -.
DR SMR; P79266; -.
DR STRING; 9913.ENSBTAP00000006892; -.
DR BindingDB; P79266; -.
DR ChEMBL; CHEMBL2720; -.
DR PaxDb; P79266; -.
DR PRIDE; P79266; -.
DR GeneID; 281665; -.
DR KEGG; bta:281665; -.
DR CTD; 887; -.
DR eggNOG; KOG3656; Eukaryota.
DR HOGENOM; CLU_009579_6_3_1; -.
DR InParanoid; P79266; -.
DR OrthoDB; 1042780at2759; -.
DR TreeFam; TF315303; -.
DR PRO; PR:P79266; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015054; F:gastrin receptor activity; ISS:UniProtKB.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; ISS:UniProtKB.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; ISS:UniProtKB.
DR InterPro; IPR009126; Cholcskin_rcpt.
DR InterPro; IPR000314; Gastrin_rcpt.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR01822; CCYSTOKININR.
DR PRINTS; PR00527; GASTRINR.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Lipoprotein; Membrane; Palmitate; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..454
FT /note="Gastrin/cholecystokinin type B receptor"
FT /id="PRO_0000069472"
FT TOPO_DOM 1..57
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..79
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 80..87
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 88..109
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 110..131
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 132..150
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 151..170
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 171..189
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 190..219
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 220..242
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 243..340
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 341..362
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 363..380
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 381..401
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 402..454
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 257..284
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 422..441
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT LIPID 415
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250|UniProtKB:P17124"
FT CARBOHYD 7
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 30
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 36
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 127..205
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT CONFLICT 386
FT /note="T -> S (in Ref. 2; AAI12801)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 454 AA; 48781 MW; A2846A580508ABA6 CRC64;
MELLKPNRSV LGSGPGPGAS LCRSGGPLLN GSGTGNLSCE PPRIRGAGTR ELELAIRVTL
YAVIFLMSVG GNVLIIVVLG LSRRLRTVTN AFLLSLAVSD LLLAVACMPF TLLPNLMGTF
IFGTVVCKAV SYFMGVSVSV STLSLVAIAL ERYSAICRPL QARVWQTRSH AARVIVATWM
LSGLLMVPYP VYTAVQPAGP RVLQCMHRWP SARVRQTWSV LLLLLLFFVP GVVMAVAYGL
ISRELYLGLR FDGDSDSESQ SRVGSQGGLP GGTGQGPAQA NGRCRSETRL AGEDGDGCYV
QLPRSRPALE MSALTAPTPG PGSGTRPAQA KLLAKKRVVR MLLVIVVLFF LCWLPVYSAN
TWRAFDGPGA HRALSGAPIS FIHLLTYASA CVNPLVYCFM HRRFRQACLD TCTRCCPRPP
RARPRPLPDE DPPTPSIASL SRLSYTTIST LGPG
