GASR_CANLF
ID GASR_CANLF Reviewed; 453 AA.
AC P30552; O46376;
DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1993, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Gastrin/cholecystokinin type B receptor;
DE Short=CCK-B receptor;
DE Short=CCK-BR;
DE AltName: Full=Cholecystokinin-2 receptor;
DE Short=CCK2-R;
GN Name=CCKBR;
OS Canis lupus familiaris (Dog) (Canis familiaris).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX NCBI_TaxID=9615;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Gastric parietal cell;
RX PubMed=1373504; DOI=10.1073/pnas.89.8.3605;
RA Kopin A.S., Lee Y.-M., McBride E.W., Miller L.J., Lu M., Lin H.Y.,
RA Kolakowski L.F. Jr., Beinborn M.;
RT "Expression cloning and characterization of the canine parietal cell
RT gastrin receptor.";
RL Proc. Natl. Acad. Sci. U.S.A. 89:3605-3609(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Song I., Blandizzi C., Brown D.R., Kang D.H., Todisco A., Delvalle J.,
RA del Tacca M., Owyang C., Yamada T.;
RT "Molecular cloning and structural analysis of the canine gastrin/CCK-B
RT receptor gene.";
RL Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Receptor for gastrin and cholecystokinin. The CCK-B receptors
CC occur throughout the central nervous system where they modulate
CC anxiety, analgesia, arousal, and neuroleptic activity. This receptor
CC mediates its action by association with G proteins that activate a
CC phosphatidylinositol-calcium second messenger system.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Parietal cells, pancreas, brain and various
CC neoplastic tissues.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; M87834; AAA30847.1; -; mRNA.
DR EMBL; AD001537; AAB87706.1; -; Genomic_DNA.
DR PIR; S32817; S32817.
DR RefSeq; NP_001013868.1; NM_001013846.1.
DR AlphaFoldDB; P30552; -.
DR SMR; P30552; -.
DR BindingDB; P30552; -.
DR ChEMBL; CHEMBL5595; -.
DR Ensembl; ENSCAFT00000104931; ENSCAFP00000075359; ENSCAFG00000006402.
DR Ensembl; ENSCAFT00030017531; ENSCAFP00030015312; ENSCAFG00030009352.
DR Ensembl; ENSCAFT00040034737; ENSCAFP00040030249; ENSCAFG00040018649.
DR Ensembl; ENSCAFT00845012829; ENSCAFP00845009998; ENSCAFG00845007238.
DR VEuPathDB; HostDB:ENSCAFG00845007238; -.
DR VGNC; VGNC:58286; CCKBR.
DR GeneTree; ENSGT01050000244933; -.
DR InParanoid; P30552; -.
DR PRO; PR:P30552; -.
DR Proteomes; UP000002254; Chromosome 21.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004951; F:cholecystokinin receptor activity; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0015054; F:gastrin receptor activity; ISS:UniProtKB.
DR GO; GO:0017046; F:peptide hormone binding; IEA:Ensembl.
DR GO; GO:0031741; F:type B gastrin/cholecystokinin receptor binding; IEA:Ensembl.
DR GO; GO:0048565; P:digestive tract development; IEA:Ensembl.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0001696; P:gastric acid secretion; IEA:Ensembl.
DR GO; GO:0048732; P:gland development; IEA:Ensembl.
DR GO; GO:0045851; P:pH reduction; IEA:Ensembl.
DR GO; GO:0007200; P:phospholipase C-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; ISS:UniProtKB.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; ISS:UniProtKB.
DR InterPro; IPR009126; Cholcskin_rcpt.
DR InterPro; IPR000314; Gastrin_rcpt.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR01822; CCYSTOKININR.
DR PRINTS; PR00527; GASTRINR.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Lipoprotein; Membrane; Palmitate; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..453
FT /note="Gastrin/cholecystokinin type B receptor"
FT /id="PRO_0000069473"
FT TOPO_DOM 1..57
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..79
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 80..87
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 88..109
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 110..131
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 132..150
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 151..170
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 171..189
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 190..220
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 221..243
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 244..339
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 340..361
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 362..379
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 380..400
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 401..453
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 258..286
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 422..453
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 436..453
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT LIPID 414
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250|UniProtKB:P17124"
FT CARBOHYD 7
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 30
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 36
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 127..206
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 453 AA; 48519 MW; 0FAEB7B994B44E1F CRC64;
MELLKLNRSA QGSGAGPGAS LCRAGGALLN SSGAGNLSCE PPRLRGAGTR ELELAIRVTL
YAVIFLMSVG GNVLIIVVLG LSRRLRTVTN AFLLSLAVSD LLLAVACMPF TLLPNLMGTF
IFGTVVCKAV SYLMGVSVSV STLSLVAIAL ERYSAICRPL QARVWQTRSH AARVIIATWM
LSGLLMVPYP VYTAVQPAGG ARALQCVHRW PSARVRQTWS VLLLLLLFFV PGVVMAVAYG
LISRELYLGL RFDEDSDSES RVRSQGGLRG GAGPGPAPPN GSCRPEGGLA GEDGDGCYVQ
LPRSRQTLEL SALTAPTPGP GGGPRPYQAK LLAKKRVVRM LLVIVVLFFL CWLPLYSANT
WRAFDSSGAH RALSGAPISF IHLLSYASAC VNPLVYCFMH RRFRQACLET CARCCPRPPR
ARPRPLPDED PPTPSIASLS RLSYTTISTL GPG
