GASR_MASNA
ID GASR_MASNA Reviewed; 450 AA.
AC P30796;
DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1993, sequence version 1.
DT 25-MAY-2022, entry version 96.
DE RecName: Full=Gastrin/cholecystokinin type B receptor;
DE Short=CCK-B receptor;
DE Short=CCK-BR;
DE AltName: Full=Cholecystokinin-2 receptor;
DE Short=CCK2-R;
GN Name=CCKBR;
OS Mastomys natalensis (African soft-furred rat) (Praomys natalensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mastomys.
OX NCBI_TaxID=10112;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=1530611; DOI=10.1016/0006-291x(92)91317-j;
RA Nakata H., Matsui T., Ito M., Taniguchi T., Naribayashi Y., Arima N.,
RA Nakamura A., Kinoshita Y., Chihara K., Hosoda S., Chiba T.;
RT "Cloning and characterization of gastrin receptor from ECL carcinoid tumor
RT of Mastomys natalensis.";
RL Biochem. Biophys. Res. Commun. 187:1151-1157(1992).
CC -!- FUNCTION: Receptor for gastrin and cholecystokinin. The CCK-B receptors
CC occur throughout the central nervous system where they modulate
CC anxiety, analgesia, arousal, and neuroleptic activity. This receptor
CC mediates its action by association with G proteins that activate a
CC phosphatidylinositol-calcium second messenger system.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Stomach and brain.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; D12817; BAA02250.1; -; mRNA.
DR PIR; JQ1614; JQ1614.
DR AlphaFoldDB; P30796; -.
DR SMR; P30796; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015054; F:gastrin receptor activity; ISS:UniProtKB.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; ISS:UniProtKB.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; ISS:UniProtKB.
DR InterPro; IPR009126; Cholcskin_rcpt.
DR InterPro; IPR000314; Gastrin_rcpt.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR01822; CCYSTOKININR.
DR PRINTS; PR00527; GASTRINR.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Lipoprotein; Membrane; Palmitate; Receptor; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..450
FT /note="Gastrin/cholecystokinin type B receptor"
FT /id="PRO_0000069476"
FT TOPO_DOM 1..57
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..79
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 80..87
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 88..109
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 110..131
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 132..150
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 151..170
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 171..189
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 190..219
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 220..242
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 243..336
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 337..358
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 359..376
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 377..397
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 398..450
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 258..277
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT LIPID 411
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250|UniProtKB:P17124"
FT CARBOHYD 7
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 30
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 36
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 127..205
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 450 AA; 48755 MW; EF13BA8B5FAA857A CRC64;
MELLKLNSSV QGPGPGSGSS LCHPGVSLLN SSSAGNLSCE PPRIRGTGTR ELELAIRITL
YAVIFLMSIG GNMLIIVVLG LSRRLRTVTN AFLLSLAVSD LLLAVACMPF TLLPNLMGTF
IFGTVICKAV SYLMGVSVSV STLNLVAIAL ERYSAICRPL QARVWQTRSH AARVILATWL
LSGLLMVPYP VYTVVQPVGP RVLQCMHRWP SARVRQTWSV LLLMLLFFIP GVVMAVAYGL
ISRELYLGLR FDGDNDSDTQ SRVRNQGGLP GGTAPGPVHQ NGGCRHVTVA GEDNDGCYVQ
LPRSRLEMTT LTTPTPGPGL ASANQAKLLA KKRVVRMLLV IVLLFFLCWL PIYSANTWCA
FDGPGAHRAL SGAPISFIHL LSYASACVNP LVYCFMHRRF RQACLDTCAR CCPRPPRARP
RPLPDEDPPT PSIASLSRLS YTTISTLGPG
