GASR_RABIT
ID GASR_RABIT Reviewed; 452 AA.
AC P46627;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 25-MAY-2022, entry version 104.
DE RecName: Full=Gastrin/cholecystokinin type B receptor;
DE Short=CCK-B receptor;
DE Short=CCK-BR;
DE AltName: Full=Cholecystokinin-2 receptor;
DE Short=CCK2-R;
GN Name=CCKBR;
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC TISSUE=Liver;
RX PubMed=8048969; DOI=10.1006/bbrc.1994.2021;
RA Blandizzi C., Song I., Yamada T.;
RT "Molecular cloning and structural analysis of the rabbit gastrin/CCKB
RT receptor gene.";
RL Biochem. Biophys. Res. Commun. 202:947-953(1994).
CC -!- FUNCTION: Receptor for gastrin and cholecystokinin. The CCK-B receptors
CC occur throughout the central nervous system where they modulate
CC anxiety, analgesia, arousal, and neuroleptic activity. This receptor
CC mediates its action by association with G proteins that activate a
CC phosphatidylinositol-calcium second messenger system.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; L31548; AAA31194.1; -; Genomic_DNA.
DR EMBL; L31547; AAA31194.1; JOINED; Genomic_DNA.
DR PIR; JC2459; JC2459.
DR AlphaFoldDB; P46627; -.
DR SMR; P46627; -.
DR STRING; 9986.ENSOCUP00000006740; -.
DR eggNOG; KOG3656; Eukaryota.
DR InParanoid; P46627; -.
DR Proteomes; UP000001811; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015054; F:gastrin receptor activity; ISS:UniProtKB.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; ISS:UniProtKB.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; ISS:UniProtKB.
DR InterPro; IPR009126; Cholcskin_rcpt.
DR InterPro; IPR000314; Gastrin_rcpt.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR01822; CCYSTOKININR.
DR PRINTS; PR00527; GASTRINR.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Lipoprotein; Membrane; Palmitate; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..452
FT /note="Gastrin/cholecystokinin type B receptor"
FT /id="PRO_0000069477"
FT TOPO_DOM 1..55
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..77
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..85
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 86..107
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 108..129
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 130..148
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 149..168
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 169..187
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 188..217
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 218..240
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 241..338
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 339..360
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 361..378
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 379..399
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 400..452
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 255..285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT LIPID 413
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250|UniProtKB:P17124"
FT CARBOHYD 7
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 28
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 34
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 125..203
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 452 AA; 48730 MW; E0716FCC1DB38870 CRC64;
MELVKLNRSV QGSGPVASLC RPGGPLLNNS GTGNLSCEPP RIRGAGTREL ELAIRVTLYA
VIFLMSVGGN ILIIVVLGLS RRLRTVTNAF LLSLAVSDLL LAVACMPFTL LPNLMGTFIF
GTVICKAVSY LMGVSVSVST LSLVAIALER YSAICRPLQA RVWQTRSHAA RVILATWLLS
GLLMVPYPVY TAVQPVGPRV LQCVHRWPSA RVRQTWSVLL LLLLFFVPGV VMAVAYGLIS
RELYLGLRFD SDSDSESQSR VRGQGGLPGG AAPGPVHQNG RCRPEAGLAG EDGDGCYVQL
PRSRPALELS ALTAPISGPG PGPRPAQAKL LAKKRVVRML LVIVVLFFMC WLPVYSANTW
RAFDGPGAHR ALSGAPISFI HLLSYASACV NPLVYCFMHR RFRQACLDTC ARCCPRPPRA
RPRPLPDEDP PTPSIASLSR LSYTTISTLG PG
