GAST_BOVIN
ID GAST_BOVIN Reviewed; 104 AA.
AC P01352; Q28114;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1991, sequence version 2.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Gastrin;
DE Contains:
DE RecName: Full=Big gastrin;
DE AltName: Full=Gastrin-34;
DE Short=G34;
DE Contains:
DE RecName: Full=Gastrin;
DE Flags: Precursor;
GN Name=GAST; Synonyms=GAS;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Liver;
RX PubMed=2608050; DOI=10.1210/mend-3-10-1585;
RA Lund T., Olsen J., Rehfeld J.F.;
RT "Cloning and sequencing of the bovine gastrin gene.";
RL Mol. Endocrinol. 3:1585-1588(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE, AND PYROGLUTAMATE FORMATION AT GLN-59.
RX PubMed=1773057; DOI=10.3109/10425179109020769;
RA Kim S.J., Uhm K.N., Kang Y.K., Yoo O.J.;
RT "Bovine and feline gastrin cDNA sequences and the amino acid and nucleotide
RT sequence homologies among mammalian species.";
RL DNA Seq. 1:181-187(1991).
RN [3]
RP PROTEIN SEQUENCE OF 76-92, PYROGLUTAMATE FORMATION AT GLN-76, SULFATION AT
RP TYR-87, AND AMIDATION AT PHE-92.
RX PubMed=5665711; DOI=10.1038/219614a0;
RA Agarwal K.L., Beacham J., Bentley P.H., Gregory R.A., Kenner G.W.,
RA Sheppard R.C., Tracy H.J.;
RT "Isolation, structure and synthesis of ovine and bovine gastrins.";
RL Nature 219:614-615(1968).
CC -!- FUNCTION: Gastrin stimulates the stomach mucosa to produce and secrete
CC hydrochloric acid and the pancreas to secrete its digestive enzymes. It
CC also stimulates smooth muscle contraction and increases blood
CC circulation and water secretion in the stomach and intestine.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the gastrin/cholecystokinin family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; M31657; AAA30537.1; -; Genomic_DNA.
DR EMBL; X16581; CAA34598.1; -; mRNA.
DR PIR; S14400; GMBO.
DR RefSeq; NP_776340.1; NM_173915.2.
DR AlphaFoldDB; P01352; -.
DR STRING; 9913.ENSBTAP00000023489; -.
DR PaxDb; P01352; -.
DR Ensembl; ENSBTAT00000023489; ENSBTAP00000023489; ENSBTAG00000017663.
DR GeneID; 280800; -.
DR KEGG; bta:280800; -.
DR CTD; 2520; -.
DR VEuPathDB; HostDB:ENSBTAG00000017663; -.
DR VGNC; VGNC:29264; GAST.
DR eggNOG; ENOG502SA9S; Eukaryota.
DR GeneTree; ENSGT00390000014792; -.
DR HOGENOM; CLU_2249245_0_0_1; -.
DR InParanoid; P01352; -.
DR OMA; KPRSQLQ; -.
DR OrthoDB; 1589970at2759; -.
DR TreeFam; TF336994; -.
DR Proteomes; UP000009136; Chromosome 19.
DR Bgee; ENSBTAG00000017663; Expressed in abomasum and 45 other tissues.
DR GO; GO:0005615; C:extracellular space; IDA:AgBase.
DR GO; GO:0005179; F:hormone activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0032094; P:response to food; IDA:AgBase.
DR InterPro; IPR039236; GAST.
DR InterPro; IPR001651; Gastrin/CCK.
DR InterPro; IPR013152; Gastrin/cholecystokinin_CS.
DR PANTHER; PTHR19309; PTHR19309; 1.
DR Pfam; PF00918; Gastrin; 1.
DR PROSITE; PS00259; GASTRIN; 1.
PE 1: Evidence at protein level;
KW Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW Hormone; Phosphoprotein; Pyrrolidone carboxylic acid; Reference proteome;
KW Secreted; Signal; Sulfation.
FT SIGNAL 1..21
FT PROPEP 22..58
FT /id="PRO_0000010609"
FT PEPTIDE 59..92
FT /note="Big gastrin"
FT /id="PRO_0000010610"
FT PEPTIDE 76..92
FT /note="Gastrin"
FT /evidence="ECO:0000269|PubMed:1773057"
FT /id="PRO_0000010611"
FT PROPEP 96..104
FT /id="PRO_0000010612"
FT REGION 27..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 59
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000269|PubMed:1773057"
FT MOD_RES 76
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000269|PubMed:5665711"
FT MOD_RES 87
FT /note="Sulfotyrosine"
FT /evidence="ECO:0000269|PubMed:5665711"
FT MOD_RES 92
FT /note="Phenylalanine amide"
FT /evidence="ECO:0000269|PubMed:5665711"
FT MOD_RES 96
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P01353"
FT CONFLICT 32
FT /note="A -> L (in Ref. 1; AAA30537)"
FT /evidence="ECO:0000305"
FT CONFLICT 37
FT /note="G -> R (in Ref. 1; AAA30537)"
FT /evidence="ECO:0000305"
FT CONFLICT 48
FT /note="N -> T (in Ref. 1; AAA30537)"
FT /evidence="ECO:0000305"
FT CONFLICT 74
FT /note="K -> N (in Ref. 1; AAA30537)"
FT /evidence="ECO:0000305"
FT CONFLICT 81
FT /note="E -> G (in Ref. 1; AAA30537)"
FT /evidence="ECO:0000305"
FT CONFLICT 96
FT /note="S -> M (in Ref. 1; AAA30537)"
FT /evidence="ECO:0000305"
FT CONFLICT 99
FT /note="E -> G (in Ref. 1; AAA30537)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 104 AA; 11573 MW; 54D03BF200F299F2 CRC64;
MQRLCAHVLI LVLALAAFCE ASWKPHSHLQ DAPVAPGANR GQEPLRMNRL GPASNPRRQL
GLQDPPHMVA DLSKKQGPWV EEEEAAYGWM DFGRRSAEEG DQHP
