ID   GAST_CANLF              Reviewed;         104 AA.
AC   P01353;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   15-JUL-1998, sequence version 3.
DT   03-AUG-2022, entry version 131.
DE   RecName: Full=Gastrin;
DE   Contains:
DE     RecName: Full=Big gastrin;
DE     AltName: Full=Gastrin-34;
DE              Short=G34;
DE   Contains:
DE     RecName: Full=Gastrin;
DE   Flags: Precursor;
GN   Name=GAST; Synonyms=GAS;
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Gastric mucosa;
RX   PubMed=2262079; DOI=10.1159/000200372;
RA   Gantz I., Takeuchi T., Yamada T.;
RT   "Cloning of canine gastrin cDNA's encoding variant amino acid sequences.";
RL   Digestion 46:99-104(1990).
RN   [2]
RP   PROTEIN SEQUENCE OF 59-92, PYROGLUTAMATE FORMATION AT GLN-59 AND GLN-76,
RP   SULFATION AT TYR-87, AND AMIDATION AT PHE-92.
RC   TISSUE=Gastric mucosa;
RX   PubMed=3763441; DOI=10.1016/0196-9781(86)90045-8;
RA   Bonato C., Eng J., Hulmes J.D., Miedel M., Pan Y.-C.E., Yalow R.S.;
RT   "Sequences of gastrins purified from a single antrum of dog and of goat.";
RL   Peptides 7:689-693(1986).
RN   [3]
RP   PROTEIN SEQUENCE OF 76-92, AND PHOSPHORYLATION.
RX   PubMed=5799207; DOI=10.1007/bf01899905;
RA   Agarwal K.L., Kenner G.W., Sheppard R.C.;
RT   "Structure and synthesis of canine gastrin.";
RL   Experientia 25:346-348(1969).
RN   [4]
RP   PROTEIN SEQUENCE OF 96-104, AND PHOSPHORYLATION AT SER-96.
RC   TISSUE=Gastric mucosa;
RX   PubMed=2756156; DOI=10.1016/0167-0115(89)90264-4;
RA   Desmond H., Varro A., Young J., Gregory H., Nemeth J., Dockray G.J.;
RT   "The constitution and properties of phosphorylated and unphosphorylated C-
RT   terminal fragments of progastrin from dog and ferret antrum.";
RL   Regul. Pept. 25:223-233(1989).
CC   -!- FUNCTION: Gastrin stimulates the stomach mucosa to produce and secrete
CC       hydrochloric acid and the pancreas to secrete its digestive enzymes. It
CC       also stimulates smooth muscle contraction and increases blood
CC       circulation and water secretion in the stomach and intestine.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the gastrin/cholecystokinin family.
CC       {ECO:0000305}.
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DR   PIR; B61053; GMDG.
DR   RefSeq; XP_003435286.1; XM_003435238.3.
DR   AlphaFoldDB; P01353; -.
DR   STRING; 9615.ENSCAFP00000023420; -.
DR   iPTMnet; P01353; -.
DR   PaxDb; P01353; -.
DR   Ensembl; ENSCAFT00030035728; ENSCAFP00030031159; ENSCAFG00030019442.
DR   Ensembl; ENSCAFT00040019141; ENSCAFP00040016613; ENSCAFG00040010324.
DR   Ensembl; ENSCAFT00845021253; ENSCAFP00845016712; ENSCAFG00845011939.
DR   GeneID; 100685087; -.
DR   KEGG; cfa:100685087; -.
DR   CTD; 2520; -.
DR   VEuPathDB; HostDB:ENSCAFG00845011939; -.
DR   eggNOG; ENOG502SA9S; Eukaryota.
DR   GeneTree; ENSGT00390000014792; -.
DR   HOGENOM; CLU_2249245_0_0_1; -.
DR   InParanoid; P01353; -.
DR   OMA; KPRSQLQ; -.
DR   OrthoDB; 1589970at2759; -.
DR   TreeFam; TF336994; -.
DR   Reactome; R-CFA-416476; G alpha (q) signalling events.
DR   Proteomes; UP000002254; Chromosome 9.
DR   Bgee; ENSCAFG00000015924; Expressed in thymus and 5 other tissues.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005179; F:hormone activity; IBA:GO_Central.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0032094; P:response to food; IBA:GO_Central.
DR   InterPro; IPR039236; GAST.
DR   InterPro; IPR001651; Gastrin/CCK.
DR   InterPro; IPR013152; Gastrin/cholecystokinin_CS.
DR   PANTHER; PTHR19309; PTHR19309; 1.
DR   Pfam; PF00918; Gastrin; 1.
DR   PROSITE; PS00259; GASTRIN; 1.
PE   1: Evidence at protein level;
KW   Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW   Hormone; Phosphoprotein; Pyrrolidone carboxylic acid; Reference proteome;
KW   Secreted; Signal; Sulfation.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   PROPEP          22..58
FT                   /evidence="ECO:0000269|PubMed:3763441"
FT                   /id="PRO_0000010613"
FT   PEPTIDE         59..92
FT                   /note="Big gastrin"
FT                   /id="PRO_0000010614"
FT   PEPTIDE         76..92
FT                   /note="Gastrin"
FT                   /id="PRO_0000010615"
FT   PROPEP          96..104
FT                   /id="PRO_0000010616"
FT   REGION          22..70
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         59
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:3763441"
FT   MOD_RES         76
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:3763441"
FT   MOD_RES         87
FT                   /note="Sulfotyrosine"
FT                   /evidence="ECO:0000269|PubMed:3763441"
FT   MOD_RES         92
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000269|PubMed:3763441"
FT   MOD_RES         96
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000269|PubMed:2756156"
FT   VARIANT         85
FT                   /note="A -> T"
FT   CONFLICT        83..85
FT                   /note="EEA -> AEE (in Ref. 3; AA sequence)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   104 AA;  11519 MW;  73BF72A18DFE78CA CRC64;
     MQRLCVYVLI LALALATFSE ASWKPRSRLQ DAPSGPGANR GLEPHGLDQL GPASHHRRQL
     GLQGPPQLVA DLSKKQGPWM EEEEAAYGWM DFGRRSAEEG DQRP