ID   GAST_CAPHI              Reviewed;          34 AA.
AC   P04564;
DT   13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 3.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Gastrin;
DE   Contains:
DE     RecName: Full=Big gastrin;
DE     AltName: Full=Gastrin-34;
DE              Short=G34;
DE   Contains:
DE     RecName: Full=Gastrin;
DE   Flags: Precursor;
GN   Name=GAST; Synonyms=GAS;
OS   Capra hircus (Goat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Capra.
OX   NCBI_TaxID=9925;
RN   [1]
RP   PROTEIN SEQUENCE, PYROGLUTAMATE FORMATION AT GLN-1 AND GLN-18, SULFATION AT
RP   TYR-29, AND AMIDATION AT PHE-34.
RC   TISSUE=Gastric mucosa;
RX   PubMed=3763441; DOI=10.1016/0196-9781(86)90045-8;
RA   Bonato C., Eng J., Hulmes J.D., Miedel M., Pan Y.-C.E., Yalow R.S.;
RT   "Sequences of gastrins purified from a single antrum of dog and of goat.";
RL   Peptides 7:689-693(1986).
CC   -!- FUNCTION: Gastrin stimulates the stomach mucosa to produce and secrete
CC       hydrochloric acid and the pancreas to secrete its digestive enzymes. It
CC       also stimulates smooth muscle contraction and increases blood
CC       circulation and water secretion in the stomach and intestine.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the gastrin/cholecystokinin family.
CC       {ECO:0000305}.
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DR   PIR; JS0426; JS0426.
DR   AlphaFoldDB; P04564; -.
DR   STRING; 9925.ENSCHIP00000003189; -.
DR   Proteomes; UP000291000; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; ISS:AgBase.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0032094; P:response to food; ISS:AgBase.
DR   InterPro; IPR013152; Gastrin/cholecystokinin_CS.
DR   PROSITE; PS00259; GASTRIN; 1.
PE   1: Evidence at protein level;
KW   Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW   Hormone; Pyrrolidone carboxylic acid; Reference proteome; Secreted;
KW   Sulfation.
FT   PEPTIDE         1..34
FT                   /note="Big gastrin"
FT                   /evidence="ECO:0000269|PubMed:3763441"
FT                   /id="PRO_0000010617"
FT   PEPTIDE         18..34
FT                   /note="Gastrin"
FT                   /evidence="ECO:0000269|PubMed:3763441"
FT                   /id="PRO_0000010618"
FT   MOD_RES         1
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:3763441"
FT   MOD_RES         18
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:3763441"
FT   MOD_RES         29
FT                   /note="Sulfotyrosine"
FT                   /evidence="ECO:0000269|PubMed:3763441"
FT   MOD_RES         34
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000269|PubMed:3763441"
SQ   SEQUENCE   34 AA;  3903 MW;  67501111E76D0CF4 CRC64;
     QLGLQDPPHM VADLSKKQGP WVEEEEAAYG WMDF