ID   GAST_CAVPO              Reviewed;          33 AA.
AC   P06885;
DT   01-JAN-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 3.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Gastrin;
DE   Contains:
DE     RecName: Full=Big gastrin;
DE     AltName: Full=Gastrin-33;
DE              Short=G33;
DE   Contains:
DE     RecName: Full=Gastrin;
DE   Flags: Precursor;
GN   Name=GAST; Synonyms=GAS;
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC   Cavia.
OX   NCBI_TaxID=10141;
RN   [1]
RP   PROTEIN SEQUENCE, PYROGLUTAMATE FORMATION AT GLN-1, AND AMIDATION AT
RP   PHE-33.
RX   PubMed=3747718; DOI=10.1016/0024-3205(86)90283-3;
RA   Bonato C., Eng J., Pan Y.-C.E., Miedel M., Hulmes J.D., Yalow R.S.;
RT   "Guinea pig 33-amino acid gastrin.";
RL   Life Sci. 39:959-964(1986).
CC   -!- FUNCTION: Gastrin stimulates the stomach mucosa to produce and secrete
CC       hydrochloric acid and the pancreas to secrete its digestive enzymes. It
CC       also stimulates smooth muscle contraction and increases blood
CC       circulation and water secretion in the stomach and intestine.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the gastrin/cholecystokinin family.
CC       {ECO:0000305}.
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DR   PIR; A26089; GMGPB.
DR   AlphaFoldDB; P06885; -.
DR   STRING; 10141.ENSCPOP00000008841; -.
DR   eggNOG; ENOG502SA9S; Eukaryota.
DR   HOGENOM; CLU_3386965_0_0_1; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR013152; Gastrin/cholecystokinin_CS.
DR   PROSITE; PS00259; GASTRIN; 1.
PE   1: Evidence at protein level;
KW   Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW   Hormone; Pyrrolidone carboxylic acid; Reference proteome; Secreted.
FT   PEPTIDE         1..33
FT                   /note="Big gastrin"
FT                   /evidence="ECO:0000269|PubMed:3747718"
FT                   /id="PRO_0000010619"
FT   PEPTIDE         18..33
FT                   /note="Gastrin"
FT                   /id="PRO_0000010620"
FT   MOD_RES         1
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:3747718"
FT   MOD_RES         33
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000269|PubMed:3747718"
SQ   SEQUENCE   33 AA;  3757 MW;  B37C251CD40EB30C CRC64;
     QLGPQVPAHL RTDLSKKQGP WAEEEAAYGW MDF