ID   GAST_CHICH              Reviewed;          33 AA.
AC   P10034;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=Gastrin;
DE   Contains:
DE     RecName: Full=Big gastrin;
DE     AltName: Full=Gastrin-33;
DE              Short=G33;
DE   Contains:
DE     RecName: Full=Gastrin;
DE   Flags: Precursor;
GN   Name=GAST; Synonyms=GAS;
OS   Chinchilla chinchilla (Short-tailed chinchilla) (Chinchilla brevicaudata).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha;
OC   Chinchillidae; Chinchilla.
OX   NCBI_TaxID=10152;
RN   [1]
RP   PROTEIN SEQUENCE, PYROGLUTAMATE FORMATION AT GLN-18, SULFATION AT TYR-28,
RP   AND AMIDATION AT PHE-33.
RX   PubMed=3827930; DOI=10.1016/0006-291x(87)90621-8;
RA   Shinomura Y., Eng J., Yalow R.S.;
RT   "Chinchilla 'big' and 'little' gastrins.";
RL   Biochem. Biophys. Res. Commun. 143:7-14(1987).
CC   -!- FUNCTION: Gastrin stimulates the stomach mucosa to produce and secrete
CC       hydrochloric acid and the pancreas to secrete its digestive enzymes. It
CC       also stimulates smooth muscle contraction and increases blood
CC       circulation and water secretion in the stomach and intestine.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the gastrin/cholecystokinin family.
CC       {ECO:0000305}.
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DR   PIR; A29541; A29541.
DR   PIR; B29541; B29541.
DR   AlphaFoldDB; P10034; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR013152; Gastrin/cholecystokinin_CS.
DR   PROSITE; PS00259; GASTRIN; 1.
PE   1: Evidence at protein level;
KW   Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW   Hormone; Pyrrolidone carboxylic acid; Secreted; Sulfation.
FT   PEPTIDE         1..33
FT                   /note="Big gastrin"
FT                   /id="PRO_0000010621"
FT   PEPTIDE         18..33
FT                   /note="Gastrin"
FT                   /id="PRO_0000010622"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         18
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:3827930"
FT   MOD_RES         28
FT                   /note="Sulfotyrosine"
FT                   /evidence="ECO:0000269|PubMed:3827930"
FT   MOD_RES         33
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000269|PubMed:3827930"
SQ   SEQUENCE   33 AA;  3715 MW;  6F11F5CDC50FAA2D CRC64;
     ELEPQGPPHL GTDLSKKQGP WAEEEAAYGW MDF