ID   GAST_DIDVI              Reviewed;          33 AA.
AC   P33713;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   25-MAY-2022, entry version 60.
DE   RecName: Full=Gastrin;
DE   Contains:
DE     RecName: Full=Big gastrin;
DE     AltName: Full=Gastrin-33;
DE              Short=G33;
DE   Contains:
DE     RecName: Full=Gastrin;
DE   Flags: Precursor;
GN   Name=GAST; Synonyms=GAS;
OS   Didelphis virginiana (North American opossum) (Didelphis marsupialis
OS   virginiana).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Metatheria; Didelphimorphia; Didelphidae; Didelphis.
OX   NCBI_TaxID=9267;
RN   [1]
RP   PROTEIN SEQUENCE, PYROGLUTAMATE FORMATION AT GLN-1 AND GLN-18, SULFATION AT
RP   TYR-28, AND AMIDATION AT PHE-33.
RX   PubMed=2361360; DOI=10.1016/0305-0491(90)90369-5;
RA   Shinomura Y., Eng J., Rattan S.C., Yalow R.S.;
RT   "Opossum (Didelphis virginiana) 'little' and 'big' gastrins.";
RL   Comp. Biochem. Physiol. 96B:239-242(1990).
CC   -!- FUNCTION: Gastrin stimulates the stomach mucosa to produce and secrete
CC       hydrochloric acid and the pancreas to secrete its digestive enzymes. It
CC       also stimulates smooth muscle contraction and increases blood
CC       circulation and water secretion in the stomach and intestine.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the gastrin/cholecystokinin family.
CC       {ECO:0000305}.
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DR   PIR; A60506; A60506.
DR   AlphaFoldDB; P33713; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR013152; Gastrin/cholecystokinin_CS.
DR   PROSITE; PS00259; GASTRIN; 1.
PE   1: Evidence at protein level;
KW   Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW   Hormone; Pyrrolidone carboxylic acid; Secreted; Sulfation.
FT   PEPTIDE         1..33
FT                   /note="Big gastrin"
FT                   /evidence="ECO:0000269|PubMed:2361360"
FT                   /id="PRO_0000010623"
FT   PEPTIDE         18..33
FT                   /note="Gastrin"
FT                   /evidence="ECO:0000269|PubMed:2361360"
FT                   /id="PRO_0000010624"
FT   MOD_RES         1
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:2361360"
FT   MOD_RES         18
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:2361360"
FT   MOD_RES         28
FT                   /note="Sulfotyrosine"
FT                   /evidence="ECO:0000269|PubMed:2361360"
FT   MOD_RES         33
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000269|PubMed:2361360"
SQ   SEQUENCE   33 AA;  3856 MW;  217D28C15027B661 CRC64;
     QLGPQDLPYL TADLSKKQGP WLEEEEAYGW MDF