GAST_FELCA
ID GAST_FELCA Reviewed; 104 AA.
AC P01354;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1991, sequence version 2.
DT 25-MAY-2022, entry version 105.
DE RecName: Full=Gastrin;
DE Contains:
DE RecName: Full=Big gastrin;
DE AltName: Full=Gastrin-34;
DE Short=G34;
DE Contains:
DE RecName: Full=Gastrin;
DE Flags: Precursor;
GN Name=GAST; Synonyms=GAS;
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND PYROGLUTAMATE FORMATION AT GLN-59.
RX PubMed=1773057; DOI=10.3109/10425179109020769;
RA Kim S.J., Uhm K.N., Kang Y.K., Yoo O.J.;
RT "Bovine and feline gastrin cDNA sequences and the amino acid and nucleotide
RT sequence homologies among mammalian species.";
RL DNA Seq. 1:181-187(1991).
RN [2]
RP PROTEIN SEQUENCE OF 76-92, PYROGLUTAMATE FORMATION AT GLN-76, SULFATION AT
RP TYR-87, AND AMIDATION AT PHE-92.
RX PubMed=5784957; DOI=10.1021/ja01039a051;
RA Agarwal K.L., Kenner G.W., Sheppard R.C.;
RT "Feline gastrin. An example of peptide sequence analysis by mass
RT spectrometry.";
RL J. Am. Chem. Soc. 91:3096-3097(1969).
CC -!- FUNCTION: Gastrin stimulates the stomach mucosa to produce and secrete
CC hydrochloric acid and the pancreas to secrete its digestive enzymes. It
CC also stimulates smooth muscle contraction and increases blood
CC circulation and water secretion in the stomach and intestine.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the gastrin/cholecystokinin family.
CC {ECO:0000305}.
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DR EMBL; X16582; CAA34599.1; -; mRNA.
DR PIR; S14401; GMCT.
DR AlphaFoldDB; P01354; -.
DR STRING; 9685.ENSFCAP00000011542; -.
DR eggNOG; ENOG502SA9S; Eukaryota.
DR InParanoid; P01354; -.
DR TreeFam; TF336994; -.
DR Proteomes; UP000011712; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR InterPro; IPR039236; GAST.
DR InterPro; IPR001651; Gastrin/CCK.
DR InterPro; IPR013152; Gastrin/cholecystokinin_CS.
DR PANTHER; PTHR19309; PTHR19309; 1.
DR Pfam; PF00918; Gastrin; 1.
DR PROSITE; PS00259; GASTRIN; 1.
PE 1: Evidence at protein level;
KW Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW Hormone; Phosphoprotein; Pyrrolidone carboxylic acid; Reference proteome;
KW Secreted; Signal; Sulfation.
FT SIGNAL 1..21
FT PROPEP 22..58
FT /id="PRO_0000010625"
FT PEPTIDE 59..92
FT /note="Big gastrin"
FT /id="PRO_0000010626"
FT PEPTIDE 76..92
FT /note="Gastrin"
FT /id="PRO_0000010627"
FT PROPEP 96..104
FT /id="PRO_0000010628"
FT REGION 22..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 59
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000269|PubMed:1773057"
FT MOD_RES 76
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000269|PubMed:5784957"
FT MOD_RES 87
FT /note="Sulfotyrosine"
FT /evidence="ECO:0000269|PubMed:5784957"
FT MOD_RES 92
FT /note="Phenylalanine amide"
FT /evidence="ECO:0000269|PubMed:5784957"
FT MOD_RES 96
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P01353"
SQ SEQUENCE 104 AA; 11482 MW; 4DB92E4416A7AC9F CRC64;
MQRLCVCVLI LALALTAFSE ASWKPRSQLQ DAPSGPGANG GLEPHWLNRL GPASHHRWQL
GLQGPPQQVA DLSKKQGPWL EEEEAAYGWM DFGRRSAEDG DQHP
