ID   GAST_HORSE              Reviewed;         107 AA.
AC   P55885;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Gastrin;
DE   Contains:
DE     RecName: Full=Big gastrin;
DE     AltName: Full=Gastrin-34;
DE              Short=G34;
DE   Contains:
DE     RecName: Full=Gastrin;
DE   Flags: Precursor;
GN   Name=GAST; Synonyms=GAS;
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 62-95, AMIDATION AT PHE-95,
RP   PYROGLUTAMATE FORMATION AT GLN-62 AND GLN-79, AND MASS SPECTROMETRY.
RC   TISSUE=Gastric mucosa;
RX   PubMed=9716385; DOI=10.1046/j.1432-1327.1998.2550432.x;
RA   Johnsen A.H., Sandin A., Rourke I.J., Bundgaard J.R., Nilsson G.,
RA   Rehfeld J.F.;
RT   "Unique progastrin processing in equine G-cells suggests marginal tyrosyl
RT   sulfotransferase activity.";
RL   Eur. J. Biochem. 255:432-438(1998).
CC   -!- FUNCTION: Gastrin stimulates the stomach mucosa to produce and secrete
CC       hydrochloric acid and the pancreas to secrete its digestive enzymes. It
CC       also stimulates smooth muscle contraction and increases blood
CC       circulation and water secretion in the stomach and intestine.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- PTM: Neither gastrin is sulfated.
CC   -!- MASS SPECTROMETRY: [Big gastrin]: Mass=3814; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:9716385};
CC   -!- MASS SPECTROMETRY: [Gastrin]: Mass=2039; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:9716385};
CC   -!- SIMILARITY: Belongs to the gastrin/cholecystokinin family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; Y09440; CAA70590.1; -; mRNA.
DR   AlphaFoldDB; P55885; -.
DR   STRING; 9796.ENSECAP00000010215; -.
DR   PaxDb; P55885; -.
DR   InParanoid; P55885; -.
DR   Proteomes; UP000002281; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005179; F:hormone activity; IBA:GO_Central.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0032094; P:response to food; IBA:GO_Central.
DR   InterPro; IPR039236; GAST.
DR   InterPro; IPR001651; Gastrin/CCK.
DR   InterPro; IPR013152; Gastrin/cholecystokinin_CS.
DR   PANTHER; PTHR19309; PTHR19309; 1.
DR   Pfam; PF00918; Gastrin; 1.
DR   PROSITE; PS00259; GASTRIN; 1.
PE   1: Evidence at protein level;
KW   Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW   Hormone; Phosphoprotein; Pyrrolidone carboxylic acid; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..21
FT   PROPEP          22..61
FT                   /evidence="ECO:0000269|PubMed:9716385"
FT                   /id="PRO_0000010629"
FT   PEPTIDE         62..95
FT                   /note="Big gastrin"
FT                   /id="PRO_0000010630"
FT   PEPTIDE         79..95
FT                   /note="Gastrin"
FT                   /id="PRO_0000010631"
FT   PROPEP          99..107
FT                   /id="PRO_0000010632"
FT   REGION          26..65
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         62
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:9716385"
FT   MOD_RES         79
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:9716385"
FT   MOD_RES         95
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000269|PubMed:9716385"
FT   MOD_RES         99
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P01353"
SQ   SEQUENCE   107 AA;  11884 MW;  104166CAAE5C234F CRC64;
     MRRLCVYVLI FALALAAFSE ASWKPCSQLQ DAPSGPGANK GLYPHWPDQL DRLGPASHHR
     RQLGLQGSPH LVADLSKKQG PWLEKEEAAY GWMDFGRRSA EEGDQSP