ID   GAST_MACGI              Reviewed;          33 AA.
AC   P0C228;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   28-NOV-2006, sequence version 1.
DT   25-MAY-2022, entry version 25.
DE   RecName: Full=Gastrin;
DE   Contains:
DE     RecName: Full=Big gastrin;
DE     AltName: Full=Gastrin-33;
DE   Contains:
DE     RecName: Full=Gastrin-16;
DE   Contains:
DE     RecName: Full=Gastrin-15;
DE   Flags: Precursor;
GN   Name=GAST;
OS   Macropus giganteus (Eastern gray kangaroo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Metatheria; Diprotodontia; Macropodidae; Macropus.
OX   NCBI_TaxID=9317;
RN   [1]
RP   PROTEIN SEQUENCE, SULFATION AT TYR-28, AND AMIDATION AT PHE-33.
RX   PubMed=8134294; DOI=10.1016/0196-9781(93)90166-e;
RA   Johnsen A.H., Shulkes A.;
RT   "Gastrin and cholecystokinin in the Eastern Grey kangaroo, Macropus
RT   giganteus giganteus.";
RL   Peptides 14:1133-1139(1993).
CC   -!- FUNCTION: Gastrin stimulates the stomach mucosa to produce and secrete
CC       hydrochloric acid and the pancreas to secrete its digestive enzymes. It
CC       also stimulates smooth muscle contraction and increases blood
CC       circulation and water secretion in the stomach and intestine.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- PTM: Sulfation enhances proteolytic processing, and blocks peptide
CC       degradation. Levels of sulfation differ between proteolytically-cleaved
CC       gastrins and between tissues (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the gastrin/cholecystokinin family.
CC       {ECO:0000305}.
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DR   AlphaFoldDB; P0C228; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR013152; Gastrin/cholecystokinin_CS.
DR   PROSITE; PS00259; GASTRIN; 1.
PE   1: Evidence at protein level;
KW   Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW   Hormone; Pyrrolidone carboxylic acid; Secreted; Sulfation.
FT   PEPTIDE         1..33
FT                   /note="Big gastrin"
FT                   /id="PRO_0000260276"
FT   PEPTIDE         18..33
FT                   /note="Gastrin-16"
FT                   /id="PRO_0000260277"
FT   PEPTIDE         19..33
FT                   /note="Gastrin-15"
FT                   /id="PRO_0000260278"
FT   MOD_RES         1
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250|UniProtKB:P01350"
FT   MOD_RES         28
FT                   /note="Sulfotyrosine"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         33
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   33 AA;  3913 MW;  17D929DB793CAA8C CRC64;
     QLHPQDLPHL MTDLSKKKGP WQEEDAAYGW MDF