ID   GAST_MACMU              Reviewed;          17 AA.
AC   P33714;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Gastrin;
GN   Name=GAST; Synonyms=GAS;
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=2003150; DOI=10.1016/0167-0115(91)90005-2;
RA   Yu J.-H., Xin Y., Eng J., Yalow R.S.;
RT   "Rhesus monkey gastroenteropancreatic hormones: relationship to human
RT   sequences.";
RL   Regul. Pept. 32:39-45(1991).
CC   -!- FUNCTION: Gastrin stimulates the stomach mucosa to produce and secrete
CC       hydrochloric acid and the pancreas to secrete its digestive enzymes. It
CC       also stimulates smooth muscle contraction and increases blood
CC       circulation and water secretion in the stomach and intestine.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- PTM: Sulfation enhances proteolytic processing, and blocks peptide
CC       degradation. Levels of sulfation differ between proteolytically-cleaved
CC       gastrins and between tissues (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the gastrin/cholecystokinin family.
CC       {ECO:0000305}.
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DR   PIR; A60071; A60071.
DR   AlphaFoldDB; P33714; -.
DR   STRING; 9544.ENSMMUP00000024644; -.
DR   eggNOG; ENOG502SA9S; Eukaryota.
DR   HOGENOM; CLU_2249245_0_0_1; -.
DR   Proteomes; UP000006718; Unplaced.
DR   GO; GO:0005615; C:extracellular space; ISS:AgBase.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0032094; P:response to food; ISS:AgBase.
DR   InterPro; IPR013152; Gastrin/cholecystokinin_CS.
DR   PROSITE; PS00259; GASTRIN; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Hormone; Pyrrolidone carboxylic acid;
KW   Reference proteome; Secreted; Sulfation.
FT   PEPTIDE         1..17
FT                   /note="Gastrin"
FT                   /id="PRO_0000043890"
FT   MOD_RES         1
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250|UniProtKB:P01350"
FT   MOD_RES         12
FT                   /note="Sulfotyrosine"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         17
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   17 AA;  2076 MW;  6F6E92C73611D39A CRC64;
     QGPWMEEEEA AYGWMDF