GAST_SHEEP
ID GAST_SHEEP Reviewed; 104 AA.
AC O02686;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1997, sequence version 1.
DT 25-MAY-2022, entry version 75.
DE RecName: Full=Gastrin;
DE Contains:
DE RecName: Full=Big gastrin;
DE AltName: Full=Gastrin-34;
DE Short=G34;
DE Contains:
DE RecName: Full=Gastrin;
DE Flags: Precursor;
GN Name=GAST; Synonyms=GAS;
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9522119; DOI=10.3109/10425179709020883;
RA Moore C., Jie R., Shulkes A., Baldwin G.S.;
RT "Molecular cloning and sequence of the ovine gastrin gene.";
RL DNA Seq. 8:39-44(1997).
RN [2]
RP PROTEIN SEQUENCE OF 76-92.
RX PubMed=5665711; DOI=10.1038/219614a0;
RA Agarwal K.L., Beacham J., Bentley P.H., Gregory R.A., Kenner G.W.,
RA Sheppard R.C., Tracy H.J.;
RT "Isolation, structure and synthesis of ovine and bovine gastrins.";
RL Nature 219:614-615(1968).
CC -!- FUNCTION: Gastrin stimulates the stomach mucosa to produce and secrete
CC hydrochloric acid and the pancreas to secrete its digestive enzymes. It
CC also stimulates smooth muscle contraction and increases blood
CC circulation and water secretion in the stomach and intestine.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- PTM: Sulfation enhances proteolytic processing, and blocks peptide
CC degradation. Levels of sulfation differ between proteolytically-cleaved
CC gastrins and between tissues (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the gastrin/cholecystokinin family.
CC {ECO:0000305}.
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DR EMBL; U92801; AAB51307.1; -; Genomic_DNA.
DR PIR; A01619; GMSH.
DR AlphaFoldDB; O02686; -.
DR STRING; 9940.ENSOARP00000018691; -.
DR eggNOG; ENOG502SA9S; Eukaryota.
DR Proteomes; UP000002356; Unplaced.
DR GO; GO:0005615; C:extracellular space; ISS:AgBase.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR GO; GO:0032094; P:response to food; ISS:AgBase.
DR InterPro; IPR039236; GAST.
DR InterPro; IPR001651; Gastrin/CCK.
DR InterPro; IPR013152; Gastrin/cholecystokinin_CS.
DR PANTHER; PTHR19309; PTHR19309; 1.
DR Pfam; PF00918; Gastrin; 1.
DR PROSITE; PS00259; GASTRIN; 1.
PE 1: Evidence at protein level;
KW Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW Hormone; Phosphoprotein; Reference proteome; Secreted; Signal; Sulfation.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT PROPEP 22..58
FT /id="PRO_0000010652"
FT PEPTIDE 59..92
FT /note="Big gastrin"
FT /id="PRO_0000010653"
FT PEPTIDE 76..92
FT /note="Gastrin"
FT /id="PRO_0000010654"
FT PROPEP 96..104
FT /id="PRO_0000010655"
FT REGION 26..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 87
FT /note="Sulfotyrosine"
FT /evidence="ECO:0000250"
FT MOD_RES 92
FT /note="Phenylalanine amide"
FT /evidence="ECO:0000250"
FT MOD_RES 96
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P01353"
SQ SEQUENCE 104 AA; 11532 MW; 624063D4B5CE5AFD CRC64;
MQRLCAHALI LVLALAAFCE ASWKPHSQLQ DAPVAPGANK GQEPLRMDRL GPASHPRRQL
GLQDPPHMVA DLSKKQGPWV EEEEAAYGWM DFGRRSAEEG DQHP