GAT12_ARATH
ID GAT12_ARATH Reviewed; 331 AA.
AC P69781; C0SVQ5;
DT 10-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=GATA transcription factor 12 {ECO:0000303|PubMed:15084732};
GN Name=GATA12 {ECO:0000303|PubMed:15084732};
GN OrderedLocusNames=At5g25830 {ECO:0000312|Araport:AT5G25830};
GN ORFNames=F18A17.80 {ECO:0000305};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130714; DOI=10.1038/35048507;
RA Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA Bevan M., Fransz P.F.;
RT "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL Nature 408:823-826(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Fujita M., Mizukado S., Seki M., Shinozaki K., Mitsuda N., Takiguchi Y.,
RA Takagi M.;
RT "ORF cloning and analysis of Arabidopsis transcription factor genes.";
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 82-331.
RX PubMed=17208962; DOI=10.1104/pp.106.090761;
RA Manfield I.W., Devlin P.F., Jen C.-H., Westhead D.R., Gilmartin P.M.;
RT "Conservation, convergence, and divergence of light-responsive, circadian-
RT regulated, and tissue-specific expression patterns during evolution of the
RT Arabidopsis GATA gene family.";
RL Plant Physiol. 143:941-958(2007).
RN [5]
RP GENE FAMILY ORGANIZATION.
RX PubMed=15084732; DOI=10.1104/pp.103.037788;
RA Reyes J.C., Muro-Pastor M.I., Florencio F.J.;
RT "The GATA family of transcription factors in Arabidopsis and rice.";
RL Plant Physiol. 134:1718-1732(2004).
RN [6]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=25265867; DOI=10.1093/pcp/pcu134;
RA Endo H., Yamaguchi M., Tamura T., Nakano Y., Nishikubo N., Yoneda A.,
RA Kato K., Kubo M., Kajita S., Katayama Y., Ohtani M., Demura T.;
RT "Multiple classes of transcription factors regulate the expression of
RT VASCULAR-RELATED NAC-DOMAIN7, a master switch of xylem vessel
RT differentiation.";
RL Plant Cell Physiol. 56:242-254(2015).
CC -!- FUNCTION: Transcriptional activator that specifically binds 5'-GATA-3'
CC or 5'-GAT-3' motifs within gene promoters. May be involved in the
CC regulation of some light-responsive genes (By similarity).
CC Transcription activator involved in xylem formation. Functions upstream
CC of NAC030/VND7, a master switch of xylem vessel differentiation
CC (PubMed:25265867). {ECO:0000250|UniProtKB:Q8LAU9,
CC ECO:0000269|PubMed:25265867}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00353}.
CC -!- TISSUE SPECIFICITY: Expressed in the vascular cylinder of roots.
CC Expressed in the differentiation zone of the root stele.
CC {ECO:0000269|PubMed:25265867}.
CC -!- MISCELLANEOUS: Overexpression of GATA12 induces the formation of
CC ectopic xylem vessel-like elements. {ECO:0000269|PubMed:25265867}.
CC -!- SIMILARITY: Belongs to the type IV zinc-finger family. Class A
CC subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=DQ875134; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305};
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DR EMBL; AC005405; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CP002688; AED93492.1; -; Genomic_DNA.
DR EMBL; AB493758; BAH30596.1; -; mRNA.
DR EMBL; DQ875134; -; NOT_ANNOTATED_CDS; mRNA.
DR RefSeq; NP_197955.1; NM_122484.3.
DR AlphaFoldDB; P69781; -.
DR STRING; 3702.AT5G25830.1; -.
DR PaxDb; P69781; -.
DR PRIDE; P69781; -.
DR EnsemblPlants; AT5G25830.1; AT5G25830.1; AT5G25830.
DR GeneID; 832652; -.
DR Gramene; AT5G25830.1; AT5G25830.1; AT5G25830.
DR KEGG; ath:AT5G25830; -.
DR Araport; AT5G25830; -.
DR TAIR; locus:2145259; AT5G25830.
DR eggNOG; KOG1601; Eukaryota.
DR HOGENOM; CLU_045755_0_0_1; -.
DR InParanoid; P69781; -.
DR OMA; RRQKEMH; -.
DR OrthoDB; 1030219at2759; -.
DR PhylomeDB; P69781; -.
DR PRO; PR:P69781; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; P69781; baseline and differential.
DR Genevisible; P69781; AT.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR GO; GO:0007623; P:circadian rhythm; IEP:TAIR.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR GO; GO:0009416; P:response to light stimulus; IEP:TAIR.
DR GO; GO:1905177; P:tracheary element differentiation; IMP:UniProtKB.
DR CDD; cd00202; ZnF_GATA; 1.
DR Gene3D; 3.30.50.10; -; 1.
DR InterPro; IPR016679; TF_GATA_pln.
DR InterPro; IPR000679; Znf_GATA.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR Pfam; PF00320; GATA; 1.
DR PIRSF; PIRSF016992; TF_GATA_plant; 1.
DR SMART; SM00401; ZnF_GATA; 1.
DR PROSITE; PS00344; GATA_ZN_FINGER_1; 1.
DR PROSITE; PS50114; GATA_ZN_FINGER_2; 1.
PE 2: Evidence at transcript level;
KW Activator; Cell wall biogenesis/degradation; Developmental protein;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..331
FT /note="GATA transcription factor 12"
FT /id="PRO_0000083442"
FT ZN_FING 215..269
FT /note="GATA-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00094"
FT REGION 30..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 105..138
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 174..218
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 139..146
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT COMPBIAS 35..49
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 116..133
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 197..218
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 331 AA; 36489 MW; 6B9DC2786622BD0E CRC64;
MEDEAHEFFH TSDFAVDDLL VDFSNDDDEE NDVVADSTTT TTITDSSNFS AADLPSFHGD
VQDGTSFSGD LCIPSDDLAD ELEWLSNIVD ESLSPEDVHK LELISGFKSR PDPKSDTGSP
ENPNSSSPIF TTDVSVPAKA RSKRSRAAAC NWASRGLLKE TFYDSPFTGE TILSSQQHLS
PPTSPPLLMA PLGKKQAVDG GHRRKKDVSS PESGGAEERR CLHCATDKTP QWRTGPMGPK
TLCNACGVRY KSGRLVPEYR PAASPTFVLA KHSNSHRKVM ELRRQKEMSR AHHEFIHHHH
GTDTAMIFDV SSDGDDYLIH HNVGPDFRQL I
