ID   GAT1A_XENLA             Reviewed;         359 AA.
AC   P23767;
DT   01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1991, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=GATA-binding factor 1-A;
DE   AltName: Full=Transcription factor xGATA-1A;
GN   Name=gata1-a; Synonyms=gata1a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC   TISSUE=Erythrocyte;
RX   PubMed=1961730; DOI=10.1073/pnas.88.23.10642;
RA   Zon L.I., Mather C., Burgess S., Bolce M.E., Harland R.M., Orkin S.H.;
RT   "Expression of GATA-binding proteins during embryonic development in
RT   Xenopus laevis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 88:10642-10646(1991).
RN   [2]
RP   FUNCTION.
RX   PubMed=11493549; DOI=10.1242/dev.128.12.2301;
RA   Mead P.E., Deconinck A.E., Huber T.L., Orkin S.H., Zon L.I.;
RT   "Primitive erythropoiesis in the Xenopus embryo: the synergistic role of
RT   LMO-2, SCL and GATA-binding proteins.";
RL   Development 128:2301-2308(2001).
CC   -!- FUNCTION: Transcription factor that acts synergistically with tal1/scl
CC       and lmo2 to specify embryonic dorsal mesoderm to a hematopoietic fate.
CC       {ECO:0000269|PubMed:11493549}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- TISSUE SPECIFICITY: Expressed in the developing ventral blood island,
CC       and in both tadpole and adult erythrocytes.
CC       {ECO:0000269|PubMed:1961730}.
CC   -!- DEVELOPMENTAL STAGE: Expressed zygotically by embryonic stage 11 (mid-
CC       gastrula). {ECO:0000269|PubMed:1961730}.
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DR   EMBL; M76566; AAA49721.1; -; mRNA.
DR   PIR; A41602; A41602.
DR   RefSeq; NP_001079109.1; NM_001085640.1.
DR   AlphaFoldDB; P23767; -.
DR   SMR; P23767; -.
DR   GeneID; 373642; -.
DR   KEGG; xla:373642; -.
DR   CTD; 373642; -.
DR   Xenbase; XB-GENE-865107; gata1.L.
DR   OrthoDB; 807790at2759; -.
DR   Proteomes; UP000186698; Chromosome 8L.
DR   Bgee; 373642; Expressed in lung and 13 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0030218; P:erythrocyte differentiation; IGI:UniProtKB.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   CDD; cd00202; ZnF_GATA; 2.
DR   Gene3D; 3.30.50.10; -; 2.
DR   InterPro; IPR039355; Transcription_factor_GATA.
DR   InterPro; IPR000679; Znf_GATA.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   PANTHER; PTHR10071; PTHR10071; 1.
DR   Pfam; PF00320; GATA; 2.
DR   PRINTS; PR00619; GATAZNFINGER.
DR   SMART; SM00401; ZnF_GATA; 2.
DR   PROSITE; PS00344; GATA_ZN_FINGER_1; 2.
DR   PROSITE; PS50114; GATA_ZN_FINGER_2; 2.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..359
FT                   /note="GATA-binding factor 1-A"
FT                   /id="PRO_0000083401"
FT   ZN_FING         178..202
FT                   /note="GATA-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00094"
FT   ZN_FING         232..256
FT                   /note="GATA-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00094"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          271..311
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          323..359
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        341..359
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   359 AA;  38995 MW;  6557BE8C52F87CB4 CRC64;
     MDYTTLTTQD PDPNYTESGL ASTSEDSQFL YGLGGESSPG HYGGAVSSRA VGGFRHSPVF
     QTFPLHWPET SAGIPSNLTA YGRSTGTLSF YPSAASALGP ITSPPLYSAS SFLLGSAPPA
     EREGSPKFLE TLKTERASPL TSDLLPLEPR SPSILQVGYI GGGGQEFSLF QSTEDRECVN
     CGATVTPLWR RDMSGHYLCN ACGLYHKMNG QNRPLIRPKK RLIVSKRAGT QCSNCHTSTT
     TLWRRNASGD PVCNACGLYY KLHNVNRPLT MKKEGIQTRN RKVSSRSKKK KQLDNPFEPP
     KAGVEEPSPY PFGPLLFHGQ MPPMGHMINP PHHFLQSPRI SHSAPAVSYR QAASGVTPP