ID   GAT1B_XENLA             Reviewed;         364 AA.
AC   P23768;
DT   01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1991, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=GATA-binding factor 1-B;
DE   AltName: Full=Transcription factor xGATA-1B;
GN   Name=gata1-b; Synonyms=gata1b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC   TISSUE=Erythrocyte;
RX   PubMed=1961730; DOI=10.1073/pnas.88.23.10642;
RA   Zon L.I., Mather C., Burgess S., Bolce M.E., Harland R.M., Orkin S.H.;
RT   "Expression of GATA-binding proteins during embryonic development in
RT   Xenopus laevis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 88:10642-10646(1991).
RN   [2]
RP   FUNCTION.
RX   PubMed=11493549; DOI=10.1242/dev.128.12.2301;
RA   Mead P.E., Deconinck A.E., Huber T.L., Orkin S.H., Zon L.I.;
RT   "Primitive erythropoiesis in the Xenopus embryo: the synergistic role of
RT   LMO-2, SCL and GATA-binding proteins.";
RL   Development 128:2301-2308(2001).
CC   -!- FUNCTION: Transcription factor that acts synergistically with tal1/scl
CC       and lmo2 to specify embryonic dorsal mesoderm to a hematopoietic fate.
CC       {ECO:0000269|PubMed:11493549}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- TISSUE SPECIFICITY: Expressed in the developing ventral blood island,
CC       and in both tadpole and adult erythrocytes.
CC       {ECO:0000269|PubMed:1961730}.
CC   -!- DEVELOPMENTAL STAGE: Expressed zygotically by embryonic stage 11 (mid-
CC       gastrula). {ECO:0000269|PubMed:1961730}.
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DR   EMBL; M76563; AAA49722.1; -; mRNA.
DR   PIR; B41602; B41602.
DR   RefSeq; NP_001079244.1; NM_001085775.1.
DR   AlphaFoldDB; P23768; -.
DR   SMR; P23768; -.
DR   GeneID; 378511; -.
DR   KEGG; xla:378511; -.
DR   CTD; 378511; -.
DR   Xenbase; XB-GENE-6252666; gata1.S.
DR   Proteomes; UP000186698; Chromosome 8S.
DR   Bgee; 378511; Expressed in lung and 14 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   CDD; cd00202; ZnF_GATA; 2.
DR   Gene3D; 3.30.50.10; -; 2.
DR   InterPro; IPR039355; Transcription_factor_GATA.
DR   InterPro; IPR000679; Znf_GATA.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   PANTHER; PTHR10071; PTHR10071; 1.
DR   Pfam; PF00320; GATA; 2.
DR   PRINTS; PR00619; GATAZNFINGER.
DR   SMART; SM00401; ZnF_GATA; 2.
DR   PROSITE; PS00344; GATA_ZN_FINGER_1; 2.
DR   PROSITE; PS50114; GATA_ZN_FINGER_2; 2.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..364
FT                   /note="GATA-binding factor 1-B"
FT                   /id="PRO_0000083402"
FT   ZN_FING         180..204
FT                   /note="GATA-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00094"
FT   ZN_FING         234..258
FT                   /note="GATA-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00094"
FT   REGION          273..318
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   364 AA;  39769 MW;  17F280FEFF89F5A4 CRC64;
     MDYTTLTTQD PLQNYTESAL ASTSEDSEFL YGLGGENSPG HYGGIVSSRA VGGFRHSPVL
     QTFPLHWPET SAGIPQSLTT YGRSPGTLPL YPSAASALGS ITSPPLYSAT PFLLGSAPLA
     ERDGSPKFLE TLKTERTSPL TSDILSLEPR SPSLLQVGYL GGGGQEFSHS LFQSTEDREC
     VNCGATVTPL WRRDLSGHYL CNACGLYHKM NGQNRPLIRP KKRLIISKRA GTQCSNCHTS
     TTTLWRRNAG GDPVCNACGL YYKLHNVNRP LTMKKEGIQT RNRKVSSKSK KKKQLENPFE
     PPKTGVEEPS PYQYGPLLFH GQMPTMGHML SPPHHFLQSP RMSHSTPAVS YRYSASGVTP
     PELA