GAT24_ARATH
ID GAT24_ARATH Reviewed; 297 AA.
AC Q8GXL7; Q8LF08; Q94B66; Q9LU42;
DT 10-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2005, sequence version 2.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=GATA transcription factor 24;
DE AltName: Full=Protein TIFY 2B;
DE AltName: Full=ZIM-like 1 protein;
GN Name=GATA24; Synonyms=TIFY2B, ZML1; OrderedLocusNames=At3g21175;
GN ORFNames=MXL8.2;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=14646219; DOI=10.1271/bbb.67.2495;
RA Shikata M., Takemura M., Yokota A., Kohchi T.;
RT "Arabidopsis ZIM, a plant-specific GATA factor, can function as a
RT transcriptional activator.";
RL Biosci. Biotechnol. Biochem. 67:2495-2497(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10819329; DOI=10.1093/dnares/7.2.131;
RA Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence
RT features of the regions of 4,504,864 bp covered by sixty P1 and TAC
RT clones.";
RL DNA Res. 7:131-135(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 161-297.
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
RN [7]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=14966217; DOI=10.1093/jxb/erh078;
RA Shikata M., Matsuda Y., Ando K., Nishii A., Takemura M., Yokota A.,
RA Kohchi T.;
RT "Characterization of Arabidopsis ZIM, a member of a novel plant-specific
RT GATA factor gene family.";
RL J. Exp. Bot. 55:631-639(2004).
RN [8]
RP GENE FAMILY ORGANIZATION.
RX PubMed=15084732; DOI=10.1104/pp.103.037788;
RA Reyes J.C., Muro-Pastor M.I., Florencio F.J.;
RT "The GATA family of transcription factors in Arabidopsis and rice.";
RL Plant Physiol. 134:1718-1732(2004).
RN [9]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=17499004; DOI=10.1016/j.tplants.2007.04.004;
RA Vanholme B., Grunewald W., Bateman A., Kohchi T., Gheysen G.;
RT "The tify family previously known as ZIM.";
RL Trends Plant Sci. 12:239-244(2007).
CC -!- FUNCTION: Transcriptional activator that specifically binds 5'-GATA-3'
CC or 5'-GAT-3' motifs within gene promoters. {ECO:0000250,
CC ECO:0000269|PubMed:14966217}.
CC -!- INTERACTION:
CC Q8GXL7; F4JJA3: At4g09060; NbExp=3; IntAct=EBI-4426127, EBI-25517233;
CC Q8GXL7; O82617: BBX23; NbExp=3; IntAct=EBI-4426127, EBI-15191793;
CC Q8GXL7; Q8L5Y6: CAND1; NbExp=3; IntAct=EBI-4426127, EBI-602912;
CC Q8GXL7; Q9ZVC9: FRS3; NbExp=3; IntAct=EBI-4426127, EBI-4448729;
CC Q8GXL7; Q8GXL7: GATA24; NbExp=4; IntAct=EBI-4426127, EBI-4426127;
CC Q8GXL7; Q9LRH6: GATA25; NbExp=13; IntAct=EBI-4426127, EBI-2460434;
CC Q8GXL7; Q8H1G0: GATA28; NbExp=9; IntAct=EBI-4426127, EBI-4435064;
CC Q8GXL7; Q9SZU7: KAI2; NbExp=3; IntAct=EBI-4426127, EBI-25519488;
CC Q8GXL7; Q9FIR9: LSU2; NbExp=3; IntAct=EBI-4426127, EBI-4424076;
CC Q8GXL7; Q8H0V5: OCP3; NbExp=4; IntAct=EBI-4426127, EBI-4428411;
CC Q8GXL7; Q9FMC8: OFP13; NbExp=4; IntAct=EBI-4426127, EBI-15204858;
CC Q8GXL7; Q9S7H5: SCL21; NbExp=6; IntAct=EBI-4426127, EBI-1238472;
CC Q8GXL7; Q9S763: WRKY45; NbExp=6; IntAct=EBI-4426127, EBI-15195723;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8GXL7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8GXL7-2; Sequence=VSP_013742;
CC -!- TISSUE SPECIFICITY: Predominantly expressed in shoot apices,
CC inflorescences and roots. {ECO:0000269|PubMed:14966217}.
CC -!- MISCELLANEOUS: [Isoform 2]: May be due to a competing donor splice
CC site. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the type IV zinc-finger family. Class C
CC subfamily. {ECO:0000305}.
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DR EMBL; AB119060; BAD02930.1; -; mRNA.
DR EMBL; AB023045; BAB01708.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE76470.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE76471.1; -; Genomic_DNA.
DR EMBL; AY042817; AAK68757.1; -; mRNA.
DR EMBL; AY064628; AAL47341.1; -; mRNA.
DR EMBL; AY085109; AAM61663.1; -; mRNA.
DR EMBL; AK118169; BAC42792.1; -; mRNA.
DR RefSeq; NP_566676.1; NM_113012.4. [Q8GXL7-1]
DR RefSeq; NP_850618.1; NM_180287.5. [Q8GXL7-2]
DR AlphaFoldDB; Q8GXL7; -.
DR SMR; Q8GXL7; -.
DR BioGRID; 7002; 41.
DR IntAct; Q8GXL7; 34.
DR STRING; 3702.AT3G21175.1; -.
DR PaxDb; Q8GXL7; -.
DR PRIDE; Q8GXL7; -.
DR ProteomicsDB; 228962; -. [Q8GXL7-1]
DR EnsemblPlants; AT3G21175.1; AT3G21175.1; AT3G21175. [Q8GXL7-1]
DR EnsemblPlants; AT3G21175.2; AT3G21175.2; AT3G21175. [Q8GXL7-2]
DR GeneID; 821670; -.
DR Gramene; AT3G21175.1; AT3G21175.1; AT3G21175. [Q8GXL7-1]
DR Gramene; AT3G21175.2; AT3G21175.2; AT3G21175. [Q8GXL7-2]
DR KEGG; ath:AT3G21175; -.
DR Araport; AT3G21175; -.
DR TAIR; locus:505006360; AT3G21175.
DR eggNOG; KOG1601; Eukaryota.
DR InParanoid; Q8GXL7; -.
DR OMA; HHHIMNG; -.
DR OrthoDB; 1089061at2759; -.
DR PhylomeDB; Q8GXL7; -.
DR PRO; PR:Q8GXL7; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q8GXL7; baseline and differential.
DR Genevisible; Q8GXL7; AT.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR CDD; cd00202; ZnF_GATA; 1.
DR Gene3D; 3.30.50.10; -; 1.
DR InterPro; IPR010402; CCT_domain.
DR InterPro; IPR045280; TIFY-like.
DR InterPro; IPR010399; Tify_dom.
DR InterPro; IPR000679; Znf_GATA.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR46125; PTHR46125; 1.
DR Pfam; PF06203; CCT; 1.
DR Pfam; PF00320; GATA; 1.
DR Pfam; PF06200; tify; 1.
DR SMART; SM00979; TIFY; 1.
DR SMART; SM00401; ZnF_GATA; 1.
DR PROSITE; PS51017; CCT; 1.
DR PROSITE; PS00344; GATA_ZN_FINGER_1; 1.
DR PROSITE; PS50114; GATA_ZN_FINGER_2; 1.
DR PROSITE; PS51320; TIFY; 1.
PE 1: Evidence at protein level;
KW Activator; Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..297
FT /note="GATA transcription factor 24"
FT /id="PRO_0000083456"
FT DOMAIN 73..108
FT /note="Tify"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00650"
FT DOMAIN 143..185
FT /note="CCT"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00357"
FT ZN_FING 213..269
FT /note="GATA-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00094"
FT REGION 178..203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 180..203
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 128..129
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14593172"
FT /id="VSP_013742"
FT CONFLICT 37
FT /note="S -> G (in Ref. 5; AAM61663)"
FT /evidence="ECO:0000305"
FT CONFLICT 273
FT /note="L -> V (in Ref. 5; AAM61663)"
FT /evidence="ECO:0000305"
FT CONFLICT 296
FT /note="T -> A (in Ref. 5; AAM61663)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 297 AA; 32883 MW; 9A150AA2CC3B1E31 CRC64;
MDDLHGRNGR MHIGVAQNPM HVQYEDHGLH HIDNENSMMD DHADGGMDEG VETDIPSHPG
NSADNRGEVV DRGIENGDQL TLSFQGQVYV FDRVSPEKVQ AVLLLLGGRE VPHTLPTTLG
SPHQNNRVLG LSGTPQRLSV PQRLASLLRF REKRKGRNFD KTIRYTVRKE VALRMQRKKG
QFTSAKSSND DSGSTGSDWG SNQSWAVEGT ETQKPEVLCR HCGTSEKSTP MMRRGPDGPR
TLCNACGLMW ANKGTLRDLS KVPPPQTPQH LSLNKNEDAN LEADQMMEVT GDISNTQ
