ID   ALGP_PSEAE              Reviewed;         352 AA.
AC   P15276; Q9HTU1;
DT   01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT   04-MAY-2001, sequence version 2.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=Transcriptional regulatory protein AlgP;
DE   AltName: Full=Alginate regulatory protein AlgR3;
GN   Name=algP; Synonyms=algR3; OrderedLocusNames=PA5253;
OS   Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS   14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208964;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=8822;
RX   PubMed=2514124; DOI=10.1016/0378-1119(89)90136-4;
RA   Kato J., Chu L., Kitano K., Devault J.D., Kimbara K., Chakrabarty A.M.,
RA   Misra T.K.;
RT   "Nucleotide sequence of a regulatory region controlling alginate synthesis
RT   in Pseudomonas aeruginosa: characterization of the algR2 gene.";
RL   Gene 84:31-38(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=8882;
RX   PubMed=2109318; DOI=10.1073/pnas.87.8.2887;
RA   Kato J., Misra T.K., Chakrabarty A.M.;
RT   "AlgR3, a protein resembling eukaryotic histone H1, regulates alginate
RT   synthesis in Pseudomonas aeruginosa.";
RL   Proc. Natl. Acad. Sci. U.S.A. 87:2887-2891(1990).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=8830;
RX   PubMed=1698761; DOI=10.1128/jb.172.10.5544-5554.1990;
RA   Deretic V., Konyecsni W.M.;
RT   "A procaryotic regulatory factor with a histone H1-like carboxy-terminal
RT   domain: clonal variation of repeats within algP, a gene involved in
RT   regulation of mucoidy in Pseudomonas aeruginosa.";
RL   J. Bacteriol. 172:5544-5554(1990).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=PAO / PA02003;
RX   PubMed=2110144; DOI=10.1128/jb.172.5.2511-2520.1990;
RA   Konyecsni W.M., Deretic V.;
RT   "DNA sequence and expression analysis of algP and algQ, components of the
RT   multigene system transcriptionally regulating mucoidy in Pseudomonas
RT   aeruginosa: algP contains multiple direct repeats.";
RL   J. Bacteriol. 172:2511-2520(1990).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA   Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA   Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT   pathogen.";
RL   Nature 406:959-964(2000).
CC   -!- FUNCTION: The promoter for a critical alginate biosynthetic gene, AlgD,
CC       encoding GDP-mannose dehydrogenase, is activated only under conditions
CC       reminiscent of the cystic fibrosis lung (i.e. under high osmolarity),
CC       and at least two regulatory genes, AlgP and AlgQ, have been implicated
CC       in this activation process.
CC   -!- DOMAIN: The C-terminal domain binds to DNA. It is unknown whether
CC       binding is specific or non-specific.
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DR   EMBL; M30145; AAA25724.1; -; Genomic_DNA.
DR   EMBL; M35259; AAA25705.1; -; Genomic_DNA.
DR   EMBL; M57551; AAA25703.1; -; Genomic_DNA.
DR   EMBL; M32077; AAA72068.1; -; Unassigned_DNA.
DR   EMBL; AE004091; AAG08638.1; -; Genomic_DNA.
DR   PIR; A35630; A35630.
DR   PIR; A36128; A36128.
DR   PIR; G82990; G82990.
DR   RefSeq; NP_253940.1; NC_002516.2.
DR   RefSeq; WP_003115263.1; NZ_QZGE01000002.1.
DR   AlphaFoldDB; P15276; -.
DR   SMR; P15276; -.
DR   STRING; 287.DR97_2623; -.
DR   PaxDb; P15276; -.
DR   PRIDE; P15276; -.
DR   DNASU; 880806; -.
DR   EnsemblBacteria; AAG08638; AAG08638; PA5253.
DR   GeneID; 880806; -.
DR   KEGG; pae:PA5253; -.
DR   PATRIC; fig|208964.12.peg.5506; -.
DR   PseudoCAP; PA5253; -.
DR   HOGENOM; CLU_070312_0_0_6; -.
DR   InParanoid; P15276; -.
DR   OMA; RRIGEQD; -.
DR   BioCyc; PAER208964:G1FZ6-5374-MON; -.
DR   Proteomes; UP000002438; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0042121; P:alginic acid biosynthetic process; IMP:PseudoCAP.
DR   GO; GO:1900190; P:regulation of single-species biofilm formation; NAS:PseudoCAP.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IMP:PseudoCAP.
PE   4: Predicted;
KW   Activator; Alginate biosynthesis; DNA-binding; Reference proteome; Repeat;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..352
FT                   /note="Transcriptional regulatory protein AlgP"
FT                   /id="PRO_0000064555"
FT   REGION          128..352
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        329..352
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        28
FT                   /note="G -> D (in Ref. 4; AAA72068)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        157..158
FT                   /note="KP -> NA (in Ref. 1 and 2)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        158
FT                   /note="P -> R (in Ref. 3)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        173..176
FT                   /note="Missing (in Ref. 1, 2 and 3)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        176
FT                   /note="A -> T (in Ref. 4; AAA72068)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        181
FT                   /note="A -> G (in Ref. 3 and 4)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        188
FT                   /note="T -> A (in Ref. 1, 2 and 3)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        223..224
FT                   /note="KP -> NA (in Ref. 1 and 2)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        246
FT                   /note="T -> A (in Ref. 1, 2 and 3)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        266..267
FT                   /note="PA -> HV (in Ref. 1, 2 and 3)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        273..280
FT                   /note="Missing (in Ref. 1, 2 and 3)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        290..291
FT                   /note="KP -> NA (in Ref. 1 and 2)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        311
FT                   /note="T -> A (in Ref. 1, 2 and 3)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        320..321
FT                   /note="KP -> NA (in Ref. 1 and 2)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   352 AA;  34491 MW;  B70C32AE67C8012E CRC64;
     MSANKKPVTT PLHLLQQLSH SLVEHLEGAC KQALVDSEKL LAKLEKQRGK AQEKLHKART
     KLQDAAKAGK TKAQAKARET ISDLEEALDT LKARQADTRT YIVGLKRDVQ ESLKLAQGVG
     KVKEAAGKAL ESRKAKPATK PAAKAAAKPA VKTVAAKPAA KPAAKPAAKP AAKPAAKTAA
     AKPAAKPTAK PAAKPAAKPA AKTAAAKPAA KPAAKPVAKP AAKPAAKTAA AKPAAKPAAK
     PVAKPTAKPA AKTAAAKPAA KPAAKPAAKP AAKPVAKSAA AKPAAKPAAK PAAKPAAKPA
     AKPVAAKPAA TKPATAPAAK PAATPSAPAA ASSAASATPA AGSNGAAPTS AS