ID   GAT5A_XENLA             Reviewed;         390 AA.
AC   P43695; Q5U4R1;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=GATA-binding factor 5-A;
DE   AltName: Full=Transcription factor xGATA-5A;
GN   Name=gata5-a; Synonyms=gata-4a, gata5a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8076520; DOI=10.1242/dev.118.3.817;
RA   Kelley C., Blumberg H., Zon L.I., Evans T.;
RT   "GATA-4 is a novel transcription factor expressed in endocardium of the
RT   developing heart.";
RL   Development 118:817-827(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   RENAME XGATA-4 TO XGATA-5.
RX   PubMed=8083222; DOI=10.1016/s0021-9258(17)31636-8;
RA   Laverriere A.C., Macneill C., Mueller C., Poelmann R.E., Burch J.B.E.,
RA   Evans T.;
RT   "GATA-4/5/6, a subfamily of three transcription factors transcribed in
RT   developing heart and gut.";
RL   J. Biol. Chem. 269:23177-23184(1994).
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- TISSUE SPECIFICITY: Highly expressed in heart and throughout the gut,
CC       with lower levels detected in lung, gonads, liver, and gall bladder.
CC   -!- DEVELOPMENTAL STAGE: In presumptive cardiac ventral mesoderm at the
CC       time that bilateral progenitors fuse and form the cardiac tube. By
CC       stage 30, expressed in the developing atria and ventricles; at stage
CC       38, in endocardial layer. By stage 40, detected in the great vessels.
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DR   EMBL; L13701; AAA63686.1; -; mRNA.
DR   EMBL; BC084985; AAH84985.1; -; mRNA.
DR   PIR; I51419; I51419.
DR   RefSeq; NP_001081962.1; NM_001088493.1.
DR   AlphaFoldDB; P43695; -.
DR   SMR; P43695; -.
DR   PRIDE; P43695; -.
DR   DNASU; 398144; -.
DR   GeneID; 398144; -.
DR   KEGG; xla:398144; -.
DR   CTD; 398144; -.
DR   Xenbase; XB-GENE-864887; gata5.S.
DR   OMA; CEPGPQP; -.
DR   OrthoDB; 807790at2759; -.
DR   Proteomes; UP000186698; Chromosome 9_10S.
DR   GO; GO:0005634; C:nucleus; IDA:MGI.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IDA:MGI.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:MGI.
DR   CDD; cd00202; ZnF_GATA; 2.
DR   Gene3D; 3.30.50.10; -; 2.
DR   InterPro; IPR008013; GATA_N.
DR   InterPro; IPR016375; TF_GATA_4/5/6.
DR   InterPro; IPR039355; Transcription_factor_GATA.
DR   InterPro; IPR000679; Znf_GATA.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   PANTHER; PTHR10071; PTHR10071; 1.
DR   Pfam; PF00320; GATA; 2.
DR   Pfam; PF05349; GATA-N; 1.
DR   PIRSF; PIRSF003028; TF_GATA_4/5/6; 1.
DR   PRINTS; PR00619; GATAZNFINGER.
DR   SMART; SM00401; ZnF_GATA; 2.
DR   PROSITE; PS00344; GATA_ZN_FINGER_1; 2.
DR   PROSITE; PS50114; GATA_ZN_FINGER_2; 2.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..390
FT                   /note="GATA-binding factor 5-A"
FT                   /id="PRO_0000083421"
FT   ZN_FING         183..207
FT                   /note="GATA-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00094"
FT   ZN_FING         237..261
FT                   /note="GATA-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00094"
FT   REGION          76..101
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          275..324
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        293..324
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   390 AA;  42168 MW;  37140BAD0660E5DF CRC64;
     MYPSLALTAN HAQPAYSHDT PNFLHSTGSP PVYVPTSRMP AMLQSLPYLQ SCDTAHQGHH
     LANHPGWAQT AESHAFNASS PHTPTGFSYS HSPPVGNSSA RDGGYQSPLI MGGGARDQYG
     NTLVRTGSYP SPYSYVGADM PPSWAAGHFE GSMLHSLQGR QSLSGRRSSL EFLEEFPGEG
     RECVNCGAMS TPLWRRDGTG HYLCNACGLY HKMNGMNRPL IKPQKRLSSS RRAGLCCTNC
     HTSTTTLWRR NSEGEPVCNA CGLYMKLHGV PRPLAMKKES IQTRKRKPKN IGKGKTSTGS
     STSANNSPSS VTNSDPTPVL KTEPNITSQY SGQAIVPVSQ GHSQTDDLVN GSHELKFMPD
     EYTYSPTALS QQSGLSVPLR QESWCALALA