ID   GAT5B_XENLA             Reviewed;         388 AA.
AC   P43696;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=GATA-binding factor 5-B;
DE   AltName: Full=Transcription factor xGATA-5B;
GN   Name=gata5-b; Synonyms=gata-4b, gata5b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8076520; DOI=10.1242/dev.118.3.817;
RA   Kelley C., Blumberg H., Zon L.I., Evans T.;
RT   "GATA-4 is a novel transcription factor expressed in endocardium of the
RT   developing heart.";
RL   Development 118:817-827(1993).
RN   [2]
RP   RENAME XGATA-4 TO XGATA-5.
RX   PubMed=8083222; DOI=10.1016/s0021-9258(17)31636-8;
RA   Laverriere A.C., Macneill C., Mueller C., Poelmann R.E., Burch J.B.E.,
RA   Evans T.;
RT   "GATA-4/5/6, a subfamily of three transcription factors transcribed in
RT   developing heart and gut.";
RL   J. Biol. Chem. 269:23177-23184(1994).
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- TISSUE SPECIFICITY: Highly expressed in heart and throughout the gut,
CC       with lower levels detected in lung, gonads, liver, and gall bladder.
CC   -!- DEVELOPMENTAL STAGE: In presumptive cardiac ventral mesoderm at the
CC       time that bilateral progenitors fuse and form the cardiac tube. By
CC       stage 30, expressed in the developing atria and ventricles; at stage
CC       38, in endocardial layer. By stage 40, detected in the great vessels.
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DR   EMBL; L13702; AAA63687.1; -; mRNA.
DR   PIR; I51420; I51420.
DR   RefSeq; NP_001079831.1; NM_001086362.1.
DR   AlphaFoldDB; P43696; -.
DR   SMR; P43696; -.
DR   DNASU; 379521; -.
DR   GeneID; 379521; -.
DR   KEGG; xla:379521; -.
DR   CTD; 379521; -.
DR   Xenbase; XB-GENE-6255488; gata5.L.
DR   OMA; YQSLAMS; -.
DR   OrthoDB; 807790at2759; -.
DR   Proteomes; UP000186698; Chromosome 9_10L.
DR   Bgee; 379521; Expressed in stomach and 16 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00202; ZnF_GATA; 2.
DR   Gene3D; 3.30.50.10; -; 2.
DR   InterPro; IPR008013; GATA_N.
DR   InterPro; IPR016375; TF_GATA_4/5/6.
DR   InterPro; IPR039355; Transcription_factor_GATA.
DR   InterPro; IPR000679; Znf_GATA.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   PANTHER; PTHR10071; PTHR10071; 1.
DR   Pfam; PF00320; GATA; 2.
DR   Pfam; PF05349; GATA-N; 1.
DR   PIRSF; PIRSF003028; TF_GATA_4/5/6; 1.
DR   PRINTS; PR00619; GATAZNFINGER.
DR   SMART; SM00401; ZnF_GATA; 2.
DR   PROSITE; PS00344; GATA_ZN_FINGER_1; 2.
DR   PROSITE; PS50114; GATA_ZN_FINGER_2; 2.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..388
FT                   /note="GATA-binding factor 5-B"
FT                   /id="PRO_0000083422"
FT   ZN_FING         184..208
FT                   /note="GATA-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00094"
FT   ZN_FING         238..262
FT                   /note="GATA-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00094"
FT   REGION          76..113
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          276..333
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        76..105
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        294..333
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   388 AA;  42106 MW;  B10AC690C23240D6 CRC64;
     MYPSLALTAN HAQPAYSHDT PNFLHSTGSP PVYVPTSRMP AMLQSLPYLQ TCDTAHQGHH
     LANHPGWAQT ANESHAFNAS SPHTPSGFSY SHSPPVGNSS ARDGGYQSPL IMGGSARDQY
     GNTLVRTGSY PSPYSYVGAD MPPSWATGHF EGSMLHSLQG RQPLPGRISS LEFLEEFHGE
     GRECVNCGAM STPLWRRDGT GHYLCNACGL YHKMNGINRP LIKPQKRLSS SRRAGLCCTN
     CHTSTTTLWR RNSEGEPVCN ACGLYMKLHG VPRPLAMKKE SIQTRKRKPK NIGKGKTSTG
     SSTSANNSPS SVTNTDPTPV LKTEPNITSH YPGQAIVPVS QGQSQTDDLV NGSHELKYIP
     EEYTYSPSAL SQQSVPLRQE SWCALALA