ID   ALGQ_PSEAE              Reviewed;         160 AA.
AC   P15275;
DT   01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1990, sequence version 1.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=Transcriptional regulatory protein AlgQ;
DE   AltName: Full=Alginate regulatory protein AlgR2;
GN   Name=algQ; Synonyms=algR2; OrderedLocusNames=PA5255;
OS   Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS   14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208964;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2514124; DOI=10.1016/0378-1119(89)90136-4;
RA   Kato J., Chu L., Kitano K., Devault J.D., Kimbara K., Chakrabarty A.M.,
RA   Misra T.K.;
RT   "Nucleotide sequence of a regulatory region controlling alginate synthesis
RT   in Pseudomonas aeruginosa: characterization of the algR2 gene.";
RL   Gene 84:31-38(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=PAO / PA02003;
RX   PubMed=2110144; DOI=10.1128/jb.172.5.2511-2520.1990;
RA   Konyecsni W.M., Deretic V.;
RT   "DNA sequence and expression analysis of algP and algQ, components of the
RT   multigene system transcriptionally regulating mucoidy in Pseudomonas
RT   aeruginosa: algP contains multiple direct repeats.";
RL   J. Bacteriol. 172:2511-2520(1990).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA   Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA   Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT   pathogen.";
RL   Nature 406:959-964(2000).
CC   -!- FUNCTION: The promoter for a critical alginate biosynthetic gene, AlgD,
CC       encoding GDP-mannose dehydrogenase, is activated only under conditions
CC       reminiscent of the cystic fibrosis lung (i.e. under high osmolarity),
CC       and at least two regulatory genes, AlgP and AlgQ, have been implicated
CC       in this activation process.
CC   -!- SIMILARITY: Belongs to the Rsd/AlgQ family. {ECO:0000305}.
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DR   EMBL; M30145; AAA25723.1; -; Genomic_DNA.
DR   EMBL; M32077; AAA72066.1; -; Unassigned_DNA.
DR   EMBL; AE004091; AAG08640.1; -; Genomic_DNA.
DR   PIR; A35261; A35261.
DR   RefSeq; NP_253942.1; NC_002516.2.
DR   RefSeq; WP_003120370.1; NZ_QZGE01000002.1.
DR   AlphaFoldDB; P15275; -.
DR   SMR; P15275; -.
DR   IntAct; P15275; 2.
DR   STRING; 287.DR97_2626; -.
DR   PaxDb; P15275; -.
DR   PRIDE; P15275; -.
DR   DNASU; 879719; -.
DR   EnsemblBacteria; AAG08640; AAG08640; PA5255.
DR   GeneID; 879719; -.
DR   KEGG; pae:PA5255; -.
DR   PATRIC; fig|208964.12.peg.5508; -.
DR   PseudoCAP; PA5255; -.
DR   HOGENOM; CLU_142729_0_0_6; -.
DR   InParanoid; P15275; -.
DR   OMA; DVIDHWL; -.
DR   PhylomeDB; P15275; -.
DR   BioCyc; PAER208964:G1FZ6-5376-MON; -.
DR   Proteomes; UP000002438; Chromosome.
DR   GO; GO:0042121; P:alginic acid biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0045861; P:negative regulation of proteolysis; IMP:PseudoCAP.
DR   GO; GO:1900378; P:positive regulation of secondary metabolite biosynthetic process; IMP:PseudoCAP.
DR   GO; GO:1900192; P:positive regulation of single-species biofilm formation; IMP:PseudoCAP.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IMP:PseudoCAP.
DR   Gene3D; 1.20.120.1370; -; 1.
DR   InterPro; IPR038309; Rsd/AlgQ_sf.
DR   InterPro; IPR007448; Sigma70_reg_Rsd_AlgQ.
DR   Pfam; PF04353; Rsd_AlgQ; 1.
DR   PIRSF; PIRSF016548; Rsd_AlgQ; 1.
PE   3: Inferred from homology;
KW   Activator; Alginate biosynthesis; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..160
FT                   /note="Transcriptional regulatory protein AlgQ"
FT                   /id="PRO_0000064556"
SQ   SEQUENCE   160 AA;  18011 MW;  9836DEFE99D24EC6 CRC64;
     MLESCRNAQE RWGGVHQLID RWLHERQQLV QAFDALSGIQ APAPNAEELQ HFCQLLLDYV
     SAGHFEVYEQ LTAEGKAFGD QRGLELAKQI FPRLEAITES ALNFNDRCDN GDCREGACLI
     AELKVLRQQL HERFELEDCL IEVLHNAHSQ SGAEGSAVPV