ID   GAT6A_XENLA             Reviewed;         391 AA.
AC   Q91678; Q6DFL7;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=GATA-binding factor 6-A;
DE   AltName: Full=Transcription factor xGATA-6a;
GN   Name=gata6-a; Synonyms=gata6, gata6a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP   STAGE.
RC   TISSUE=Heart, and Intestine;
RX   PubMed=8631498; DOI=10.1006/dbio.1996.0071;
RA   Jiang Y., Evans T.;
RT   "The Xenopus GATA-4/5/6 genes are associated with cardiac specification and
RT   can regulate cardiac-specific transcription during embryogenesis.";
RL   Dev. Biol. 174:258-270(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcriptional activator that binds 5'-GATA-3'-containing
CC       motifs within gene promoters (By similarity). Regulates cardiac-
CC       specific transcription during embryogenesis and thereby cardiogenesis.
CC       {ECO:0000250, ECO:0000269|PubMed:8631498}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- TISSUE SPECIFICITY: In embryos, expressed in the presumptive heart
CC       mesoderm. In adults, expressed at high levels in heart, small
CC       intestine, and stomach and at lower levels in lung, pancreas and colon.
CC       {ECO:0000269|PubMed:8631498}.
CC   -!- DEVELOPMENTAL STAGE: Expression is up-regulated during gastrulation.
CC       {ECO:0000269|PubMed:8631498}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH76718.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; U45454; AAB05648.1; -; mRNA.
DR   EMBL; BC076718; AAH76718.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001081452.1; NM_001087983.1.
DR   AlphaFoldDB; Q91678; -.
DR   SMR; Q91678; -.
DR   GeneID; 397845; -.
DR   KEGG; xla:397845; -.
DR   CTD; 397845; -.
DR   Xenbase; XB-GENE-6252341; gata6.S.
DR   OrthoDB; 807790at2759; -.
DR   Proteomes; UP000186698; Chromosome 6S.
DR   Bgee; 397845; Expressed in stomach and 12 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00202; ZnF_GATA; 2.
DR   Gene3D; 3.30.50.10; -; 2.
DR   InterPro; IPR008013; GATA_N.
DR   InterPro; IPR016375; TF_GATA_4/5/6.
DR   InterPro; IPR028437; TF_GATA_6.
DR   InterPro; IPR039355; Transcription_factor_GATA.
DR   InterPro; IPR000679; Znf_GATA.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   PANTHER; PTHR10071; PTHR10071; 1.
DR   PANTHER; PTHR10071:SF23; PTHR10071:SF23; 1.
DR   Pfam; PF00320; GATA; 2.
DR   Pfam; PF05349; GATA-N; 1.
DR   PIRSF; PIRSF003028; TF_GATA_4/5/6; 1.
DR   PRINTS; PR00619; GATAZNFINGER.
DR   SMART; SM00401; ZnF_GATA; 2.
DR   PROSITE; PS00344; GATA_ZN_FINGER_1; 2.
DR   PROSITE; PS50114; GATA_ZN_FINGER_2; 2.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..391
FT                   /note="GATA-binding factor 6-A"
FT                   /id="PRO_0000083428"
FT   ZN_FING         182..206
FT                   /note="GATA-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00094"
FT   ZN_FING         236..260
FT                   /note="GATA-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00094"
FT   REGION          57..111
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          274..355
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        57..85
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        95..111
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        292..355
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   391 AA;  41780 MW;  22DFFC3B2D499B86 CRC64;
     MYQTLTITSA QGPLSYDPSP GTFMHSAASS PVYVPTSRVG SMLTSISYLQ GTGASQGAHS
     VNSHWSQATS ESSSFNNSSP HTSSRYHYPP SPPMHNGSTR DTGYSSSLTV SSRDQYTPLA
     RSLNGSYGSH YTPYMAPQLT SAWPAGPFDN TMLHSLQSRG APISVRGAPG DVLDELPESR
     ECVNCGSVQT PLWRRDGTGH FLCNACGLYS KMNGLSRPLI KPQKRVPSSR RIGLACANCH
     TSTTTLWRRN TEGEPVCNAC GLYMKLHGVP RPLAMKKEGI QTRKRKPKTL NKSKSSSSNG
     NSSHQISMTP TSTTSSTNSD DCIKNGSPSQ NTTPVVASSL MSTQQTESTS PNSNTLKYTG
     QDGLYSAVSL SSASEVAASV RQDSWCALAL A