ID   GAT6B_XENLA             Reviewed;         391 AA.
AC   P70005; Q641I8;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=GATA-binding factor 6-B;
DE   AltName: Full=Transcription factor xGATA-6b;
GN   Name=gata6-b; Synonyms=gata6, gata6b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP   STAGE.
RC   TISSUE=Liver;
RX   PubMed=9029155; DOI=10.1093/emboj/16.2.355;
RA   Gove C.D., Walmsley M., Nijjar S., Bertwistle D., Guille M., Partington G.,
RA   Bomford A., Patient R.;
RT   "Over-expression of GATA-6 in Xenopus embryos blocks differentiation of
RT   heart precursors.";
RL   EMBO J. 16:355-368(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Gastrula;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcriptional activator that binds 5'-GATA-3'-containing
CC       motifs within gene promoters. Regulates cardiac-specific transcription
CC       during embryogenesis and thereby cardiogenesis.
CC       {ECO:0000269|PubMed:9029155}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- TISSUE SPECIFICITY: In embryos, expressed in the presumptive heart
CC       mesoderm. In adults, widely distributed but predominant in the heart.
CC       {ECO:0000269|PubMed:9029155}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in embryos from the early gastrula stage
CC       (stage 10.5). Peak expression occurs at neurula stages (stages 11 to
CC       17), with progressive reduction from the mid tailbud stage (stage 24)
CC       onwards. Still expressed in swimming tadpoles (stage 40) and in adults.
CC       {ECO:0000269|PubMed:9029155}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH82349.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; Y08865; CAA70088.1; -; mRNA.
DR   EMBL; BC082349; AAH82349.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001083725.1; NM_001090256.1.
DR   AlphaFoldDB; P70005; -.
DR   SMR; P70005; -.
DR   GeneID; 399082; -.
DR   KEGG; xla:399082; -.
DR   CTD; 399082; -.
DR   Xenbase; XB-GENE-865113; gata6.L.
DR   OrthoDB; 807790at2759; -.
DR   Proteomes; UP000186698; Chromosome 6L.
DR   Bgee; 399082; Expressed in stomach and 12 other tissues.
DR   GO; GO:0005634; C:nucleus; IC:UniProtKB.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IDA:UniProtKB.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0048738; P:cardiac muscle tissue development; IMP:BHF-UCL.
DR   GO; GO:0035051; P:cardiocyte differentiation; IMP:UniProtKB.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:UniProtKB.
DR   CDD; cd00202; ZnF_GATA; 2.
DR   Gene3D; 3.30.50.10; -; 2.
DR   InterPro; IPR008013; GATA_N.
DR   InterPro; IPR016375; TF_GATA_4/5/6.
DR   InterPro; IPR028437; TF_GATA_6.
DR   InterPro; IPR039355; Transcription_factor_GATA.
DR   InterPro; IPR000679; Znf_GATA.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   PANTHER; PTHR10071; PTHR10071; 1.
DR   PANTHER; PTHR10071:SF23; PTHR10071:SF23; 1.
DR   Pfam; PF00320; GATA; 2.
DR   Pfam; PF05349; GATA-N; 1.
DR   PIRSF; PIRSF003028; TF_GATA_4/5/6; 1.
DR   PRINTS; PR00619; GATAZNFINGER.
DR   SMART; SM00401; ZnF_GATA; 2.
DR   PROSITE; PS00344; GATA_ZN_FINGER_1; 2.
DR   PROSITE; PS50114; GATA_ZN_FINGER_2; 2.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..391
FT                   /note="GATA-binding factor 6-B"
FT                   /id="PRO_0000083429"
FT   ZN_FING         182..206
FT                   /note="GATA-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00094"
FT   ZN_FING         236..260
FT                   /note="GATA-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00094"
FT   REGION          57..107
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          277..334
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        292..334
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   391 AA;  41503 MW;  C93C0CDE246204D3 CRC64;
     MYQTLTITAA QGPLGYDPSP GTFMHSAASS PVYVPTSRVG SMLTSISYLQ GTGASQGTHS
     VNSHWSQATS ESSSYSSSSP HPSSRYHYSP SPPMANGSTR DTGYSSSLAV SGRDQYAPLA
     RPLNGSYGSP YTPYMTPQLT SAWPAGPFDN TMLHSLQSRG APISVRGAPG DVLDELPESR
     ECVNCGSVQT PLWRRDGTGH YLCNACGLYS KMNGLSRPLI KPQKRVPSSR RIGLACANCH
     TTTTTLWRRN TEGEPVCNAC GLYMKLHGVP RPLAMKKEGI QTRKRKPKNL NKSKSSSSNG
     NSSHHITMTP TSTTSSTNSD DCIKNGSPSQ NTAPVVTSSL MSAQQTGSAS PDSNILKYTG
     QDGLYSAVSL SSASEVAASV RQDSWCALAL A