ID   ALGR_PSEAE              Reviewed;         248 AA.
AC   P26275; Q6LDH9;
DT   01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1992, sequence version 1.
DT   03-AUG-2022, entry version 147.
DE   RecName: Full=Positive alginate biosynthesis regulatory protein;
GN   Name=algR; OrderedLocusNames=PA5261;
OS   Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS   14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208964;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=8821;
RX   PubMed=2493441; DOI=10.1128/jb.171.3.1278-1283.1989;
RA   Deretic V., Dikshit R., Konyecsni W.M., Chakrabarty A.M., Misra T.K.;
RT   "The algR gene, which regulates mucoidy in Pseudomonas aeruginosa, belongs
RT   to a class of environmentally responsive genes.";
RL   J. Bacteriol. 171:1278-1283(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA   Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA   Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT   pathogen.";
RL   Nature 406:959-964(2000).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-9.
RX   PubMed=2544550; DOI=10.1128/jb.171.7.3680-3688.1989;
RA   Deretic V., Konyecsni W.M.;
RT   "Control of mucoidy in Pseudomonas aeruginosa: transcriptional regulation
RT   of algR and identification of the second regulatory gene, algQ.";
RL   J. Bacteriol. 171:3680-3688(1989).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 228-248.
RX   PubMed=8159168; DOI=10.1007/bf00391011;
RA   Mohr C.D., Sonsteby S.K., Deretic V.;
RT   "The Pseudomonas aeruginosa homologs of hemC and hemD are linked to the
RT   gene encoding the regulator of mucoidy AlgR.";
RL   Mol. Gen. Genet. 242:177-184(1994).
CC   -!- FUNCTION: Positive regulator of the algD gene, which codes for a GDP-
CC       mannose dehydrogenase, a key step enzyme in the alginate biosynthesis
CC       pathway.
CC   -!- PATHWAY: Glycan biosynthesis; alginate biosynthesis [regulation].
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DR   EMBL; M23230; AAA25704.1; -; Genomic_DNA.
DR   EMBL; AE004091; AAG08646.1; -; Genomic_DNA.
DR   EMBL; M29096; AAA25706.1; -; Genomic_DNA.
DR   EMBL; M74844; AAA18906.1; -; Genomic_DNA.
DR   PIR; A32802; A32802.
DR   RefSeq; NP_253948.1; NC_002516.2.
DR   RefSeq; WP_003096397.1; NZ_QZGE01000002.1.
DR   AlphaFoldDB; P26275; -.
DR   SMR; P26275; -.
DR   STRING; 287.DR97_2632; -.
DR   PaxDb; P26275; -.
DR   PRIDE; P26275; -.
DR   DNASU; 877674; -.
DR   EnsemblBacteria; AAG08646; AAG08646; PA5261.
DR   GeneID; 877674; -.
DR   KEGG; pae:PA5261; -.
DR   PATRIC; fig|208964.12.peg.5514; -.
DR   PseudoCAP; PA5261; -.
DR   HOGENOM; CLU_000445_14_1_6; -.
DR   InParanoid; P26275; -.
DR   OMA; THISART; -.
DR   PhylomeDB; P26275; -.
DR   BioCyc; PAER208964:G1FZ6-5382-MON; -.
DR   UniPathway; UPA00286; -.
DR   PHI-base; PHI:6994; -.
DR   PHI-base; PHI:8158; -.
DR   Proteomes; UP000002438; Chromosome.
DR   CollecTF; EXPREG_000009d0; -.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0032993; C:protein-DNA complex; IMP:CollecTF.
DR   GO; GO:0001216; F:DNA-binding transcription activator activity; IPI:CollecTF.
DR   GO; GO:0001217; F:DNA-binding transcription repressor activity; IMP:CollecTF.
DR   GO; GO:0000156; F:phosphorelay response regulator activity; IBA:GO_Central.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IPI:CollecTF.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IMP:CollecTF.
DR   GO; GO:0042121; P:alginic acid biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0071978; P:bacterial-type flagellum-dependent swarming motility; IMP:PseudoCAP.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEP:CollecTF.
DR   GO; GO:2000147; P:positive regulation of cell motility; IMP:PseudoCAP.
DR   GO; GO:1900192; P:positive regulation of single-species biofilm formation; IMP:PseudoCAP.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; EXP:CollecTF.
DR   GO; GO:1901031; P:regulation of response to reactive oxygen species; IMP:PseudoCAP.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; EXP:CollecTF.
DR   GO; GO:0043107; P:type IV pilus-dependent motility; IMP:PseudoCAP.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR007492; LytTR_DNA-bd_dom.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR039420; WalR-like.
DR   PANTHER; PTHR48111; PTHR48111; 1.
DR   Pfam; PF04397; LytTR; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   SMART; SM00850; LytTR; 1.
DR   SMART; SM00448; REC; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS50930; HTH_LYTTR; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   3: Inferred from homology;
KW   Activator; Alginate biosynthesis; DNA-binding; Phosphoprotein;
KW   Reference proteome; Transcription; Transcription regulation;
KW   Two-component regulatory system.
FT   CHAIN           1..248
FT                   /note="Positive alginate biosynthesis regulatory protein"
FT                   /id="PRO_0000081007"
FT   DOMAIN          2..117
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   DOMAIN          142..247
FT                   /note="HTH LytTR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00112"
FT   MOD_RES         54
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ   SEQUENCE   248 AA;  27608 MW;  A3C0E614D6CE8C52 CRC64;
     MNVLIVDDEP LARERLARLV GQLDGYRVLE PSASNGEEAL TLIDSLKPDI VLLDIRMPGL
     DGLQVAARLC EREAPPAVIF CTAHDEFALE AFQVSAVGYL VKPVRSEDLA EALKKASRPN
     RVQLAALTKP PASGGSGPRS HISARTRKGI ELIPLEEVIF FIADHKYVTL RHAQGEVLLD
     EPLKALEDEF GERFVRIHRN ALVARERIER LQRTPLGHFQ LYLKGLDGDA LTVSRRHVAG
     VRRLMHQL