GATA2_CHICK
ID GATA2_CHICK Reviewed; 466 AA.
AC P23824;
DT 01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1991, sequence version 1.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=GATA-binding factor 2;
DE Short=GATA-2;
DE AltName: Full=Transcription factor NF-E1b;
GN Name=GATA2;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2017177; DOI=10.1128/mcb.11.5.2778-2784.1991;
RA Ko L.J., Yamamoto M., Leonard M.W., George K.M., Ting P., Engel J.D.;
RT "Murine and human T-lymphocyte GATA-3 factors mediate transcription through
RT a cis-regulatory element within the human T-cell receptor delta gene
RT enhancer.";
RL Mol. Cell. Biol. 11:2778-2784(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2249770; DOI=10.1101/gad.4.10.1650;
RA Yamamoto M., Ko L.J., Leonard M.W., Beug H., Orkin S.H., Engel J.D.;
RT "Activity and tissue-specific expression of the transcription factor NF-E1
RT multigene family.";
RL Genes Dev. 4:1650-1662(1990).
CC -!- FUNCTION: Transcriptional activator which probably serves as a general
CC switch factor for cell-specific development. It binds to DNA sites with
CC the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of
CC genes.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- TISSUE SPECIFICITY: Expressed in all developmental stages of erythroid
CC cells but is additionally found in a limited subset of other tissues.
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DR EMBL; X56930; CAA40252.1; -; mRNA.
DR PIR; A36389; A36389.
DR RefSeq; NP_001003797.1; NM_001003797.1.
DR RefSeq; XP_015148565.1; XM_015293079.1.
DR AlphaFoldDB; P23824; -.
DR SMR; P23824; -.
DR BioGRID; 677582; 1.
DR STRING; 9031.ENSGALP00000030109; -.
DR PaxDb; P23824; -.
DR Ensembl; ENSGALT00000030746; ENSGALP00000030109; ENSGALG00000005909.
DR Ensembl; ENSGALT00000060592; ENSGALP00000053966; ENSGALG00000005909.
DR GeneID; 416018; -.
DR KEGG; gga:416018; -.
DR CTD; 2624; -.
DR VEuPathDB; HostDB:geneid_416018; -.
DR eggNOG; KOG1601; Eukaryota.
DR GeneTree; ENSGT00940000156315; -.
DR HOGENOM; CLU_027524_1_0_1; -.
DR InParanoid; P23824; -.
DR OMA; WTVSPFT; -.
DR OrthoDB; 1240204at2759; -.
DR PhylomeDB; P23824; -.
DR Reactome; R-GGA-8939236; RUNX1 regulates transcription of genes involved in differentiation of HSCs.
DR Reactome; R-GGA-983231; Factors involved in megakaryocyte development and platelet production.
DR PRO; PR:P23824; -.
DR Proteomes; UP000000539; Chromosome 12.
DR Bgee; ENSGALG00000005909; Expressed in granulocyte and 9 other tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0001223; F:transcription coactivator binding; IPI:BHF-UCL.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0045165; P:cell fate commitment; IBA:GO_Central.
DR GO; GO:0030097; P:hemopoiesis; IEA:InterPro.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0045766; P:positive regulation of angiogenesis; IBA:GO_Central.
DR GO; GO:1902895; P:positive regulation of miRNA transcription; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00202; ZnF_GATA; 2.
DR Gene3D; 3.30.50.10; -; 2.
DR InterPro; IPR029522; GATA-2.
DR InterPro; IPR016374; TF_GATA-2/3.
DR InterPro; IPR039355; Transcription_factor_GATA.
DR InterPro; IPR000679; Znf_GATA.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR10071; PTHR10071; 1.
DR PANTHER; PTHR10071:SF149; PTHR10071:SF149; 1.
DR Pfam; PF00320; GATA; 2.
DR PIRSF; PIRSF003027; TF_GATA-1/2/3; 1.
DR PRINTS; PR00619; GATAZNFINGER.
DR SMART; SM00401; ZnF_GATA; 2.
DR PROSITE; PS00344; GATA_ZN_FINGER_1; 2.
DR PROSITE; PS50114; GATA_ZN_FINGER_2; 2.
PE 2: Evidence at transcript level;
KW Activator; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..466
FT /note="GATA-binding factor 2"
FT /id="PRO_0000083406"
FT ZN_FING 281..305
FT /note="GATA-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00094"
FT ZN_FING 335..359
FT /note="GATA-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00094"
FT REGION 139..196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 436..466
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 139..157
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 174..191
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 442..457
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 466 AA; 50150 MW; 83F990D25413F3F1 CRC64;
MEVATDQPRW MTHHAVLNGQ HPESHHPGLA HNYMEPAQLL PPDEVDVFFN HLDSQGNPYY
ANSAHARARV SYSQAHARLT GSQMCRPHLI HSPGIPWLDS SKAALSAHHH NPWTVNPFTK
TPLHPSAAGA PGAISVYPGS STSSTASVSS LTPASHSGSH LFGFPPTPPK EVSPDPNSTS
AASPSSSAGA RQEDKDSIKY QVSLSEGMKM ESASPLRSSL TSMGAQPSTH HPIPTYPSYV
PAAHDYSSSL FHPGSFLGGP ASSFTPKPRS KARSCSEGRE CVNCGATATP LWRRDGTGHY
LCNACGLYHK MNGQNRPLIK PKRRLSAARR AGTCCANCQT TTTTLWRRNA NGDPVCNACG
LYYKLHNVNR PLTMKKEGIQ TRNRKMSNKS KKSKKGSECF EELSKCMQEK SSPFSAAALA
SHMAPMGHLP PFSHSGHILP TPTPIHPSSS ISFGHPHPSS MVTAMG
