GATA2_MOUSE
ID GATA2_MOUSE Reviewed; 480 AA.
AC O09100;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 27-MAY-2002, sequence version 2.
DT 03-AUG-2022, entry version 164.
DE RecName: Full=Endothelial transcription factor GATA-2;
DE AltName: Full=GATA-binding protein 2;
GN Name=Gata2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Liver;
RA Suwabe N., Minegishi N., Yamamoto M.;
RL Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP GENOMIC ORGANIZATION.
RX PubMed=9452491; DOI=10.1074/jbc.273.6.3625;
RA Minegishi N., Ohta J., Suwabe N., Nakauchi H., Ishihara H., Hayashi N.,
RA Yamamoto M.;
RT "Alternative promoters regulate transcription of the mouse GATA-2 gene.";
RL J. Biol. Chem. 273:3625-3634(1998).
RN [3]
RP INTERACTION WITH BRD3.
RX PubMed=21536911; DOI=10.1073/pnas.1102140108;
RA Lamonica J.M., Deng W., Kadauke S., Campbell A.E., Gamsjaeger R., Wang H.,
RA Cheng Y., Billin A.N., Hardison R.C., Mackay J.P., Blobel G.A.;
RT "Bromodomain protein Brd3 associates with acetylated GATA1 to promote its
RT chromatin occupancy at erythroid target genes.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:E159-E168(2011).
CC -!- FUNCTION: Transcriptional activator which regulates endothelin-1 gene
CC expression in endothelial cells. Binds to the consensus sequence 5'-
CC AGATAG-3'.
CC -!- SUBUNIT: Interacts with BRD3. Interacts with AR and CCAR1 (By
CC similarity). {ECO:0000250|UniProtKB:P23769,
CC ECO:0000269|PubMed:21536911}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
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DR EMBL; AB000096; BAA19053.2; -; mRNA.
DR CCDS; CCDS20333.1; -.
DR RefSeq; NP_032116.4; NM_008090.5.
DR RefSeq; XP_006505602.1; XM_006505539.3.
DR AlphaFoldDB; O09100; -.
DR SMR; O09100; -.
DR BioGRID; 199839; 3.
DR CORUM; O09100; -.
DR STRING; 10090.ENSMUSP00000015197; -.
DR iPTMnet; O09100; -.
DR PhosphoSitePlus; O09100; -.
DR PaxDb; O09100; -.
DR PRIDE; O09100; -.
DR ProteomicsDB; 267565; -.
DR ABCD; O09100; 31 sequenced antibodies.
DR Antibodypedia; 788; 497 antibodies from 37 providers.
DR DNASU; 14461; -.
DR Ensembl; ENSMUST00000015197; ENSMUSP00000015197; ENSMUSG00000015053.
DR Ensembl; ENSMUST00000170089; ENSMUSP00000128198; ENSMUSG00000015053.
DR GeneID; 14461; -.
DR KEGG; mmu:14461; -.
DR UCSC; uc009cvc.2; mouse.
DR CTD; 2624; -.
DR MGI; MGI:95662; Gata2.
DR VEuPathDB; HostDB:ENSMUSG00000015053; -.
DR eggNOG; KOG1601; Eukaryota.
DR GeneTree; ENSGT00940000156315; -.
DR HOGENOM; CLU_027524_1_0_1; -.
DR InParanoid; O09100; -.
DR OMA; WTVSPFT; -.
DR OrthoDB; 1240204at2759; -.
DR PhylomeDB; O09100; -.
DR TreeFam; TF315391; -.
DR Reactome; R-MMU-8939236; RUNX1 regulates transcription of genes involved in differentiation of HSCs.
DR Reactome; R-MMU-983231; Factors involved in megakaryocyte development and platelet production.
DR BioGRID-ORCS; 14461; 7 hits in 73 CRISPR screens.
DR ChiTaRS; Gata2; mouse.
DR PRO; PR:O09100; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; O09100; protein.
DR Bgee; ENSMUSG00000015053; Expressed in seminal vesicle and 236 other tissues.
DR ExpressionAtlas; O09100; baseline and differential.
DR Genevisible; O09100; MM.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0005667; C:transcription regulator complex; IDA:MGI.
DR GO; GO:0070742; F:C2H2 zinc finger domain binding; ISO:MGI.
DR GO; GO:0003682; F:chromatin binding; IDA:MGI.
DR GO; GO:0003677; F:DNA binding; IDA:MGI.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:MGI.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISO:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISO:MGI.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:MGI.
DR GO; GO:0061629; F:RNA polymerase II-specific DNA-binding transcription factor binding; ISO:MGI.
DR GO; GO:0043565; F:sequence-specific DNA binding; ISO:MGI.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0001223; F:transcription coactivator binding; IPI:BHF-UCL.
DR GO; GO:0001221; F:transcription coregulator binding; ISO:MGI.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0001525; P:angiogenesis; IMP:MGI.
DR GO; GO:0050873; P:brown fat cell differentiation; IMP:MGI.
DR GO; GO:0021533; P:cell differentiation in hindbrain; IMP:MGI.
DR GO; GO:0045165; P:cell fate commitment; IBA:GO_Central.
DR GO; GO:0001709; P:cell fate determination; IDA:MGI.
DR GO; GO:0021954; P:central nervous system neuron development; IMP:MGI.
DR GO; GO:0090102; P:cochlea development; IEA:Ensembl.
DR GO; GO:0021902; P:commitment of neuronal cell to specific neuron type in forebrain; IMP:MGI.
DR GO; GO:0060216; P:definitive hemopoiesis; IMP:MGI.
DR GO; GO:0001892; P:embryonic placenta development; IMP:MGI.
DR GO; GO:0035854; P:eosinophil fate commitment; ISO:MGI.
DR GO; GO:0097154; P:GABAergic neuron differentiation; IMP:MGI.
DR GO; GO:0002067; P:glandular epithelial cell differentiation; IMP:MGI.
DR GO; GO:0002071; P:glandular epithelial cell maturation; IMP:MGI.
DR GO; GO:0002244; P:hematopoietic progenitor cell differentiation; IMP:MGI.
DR GO; GO:0061484; P:hematopoietic stem cell homeostasis; IMP:MGI.
DR GO; GO:0048873; P:homeostasis of number of cells within a tissue; IMP:MGI.
DR GO; GO:0042472; P:inner ear morphogenesis; IMP:MGI.
DR GO; GO:0030099; P:myeloid cell differentiation; IMP:MGI.
DR GO; GO:1903444; P:negative regulation of brown fat cell differentiation; IMP:MGI.
DR GO; GO:2000352; P:negative regulation of endothelial cell apoptotic process; ISO:MGI.
DR GO; GO:0045599; P:negative regulation of fat cell differentiation; ISO:MGI.
DR GO; GO:0070345; P:negative regulation of fat cell proliferation; ISO:MGI.
DR GO; GO:0010629; P:negative regulation of gene expression; ISO:MGI.
DR GO; GO:1901533; P:negative regulation of hematopoietic progenitor cell differentiation; IMP:MGI.
DR GO; GO:0045650; P:negative regulation of macrophage differentiation; IDA:MGI.
DR GO; GO:0045638; P:negative regulation of myeloid cell differentiation; IMP:MGI.
DR GO; GO:2000178; P:negative regulation of neural precursor cell proliferation; IMP:MGI.
DR GO; GO:0045746; P:negative regulation of Notch signaling pathway; ISO:MGI.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:MGI.
DR GO; GO:0061351; P:neural precursor cell proliferation; IMP:MGI.
DR GO; GO:0061101; P:neuroendocrine cell differentiation; IMP:MGI.
DR GO; GO:0030182; P:neuron differentiation; IMP:MGI.
DR GO; GO:0048663; P:neuron fate commitment; IMP:MGI.
DR GO; GO:0001764; P:neuron migration; ISO:MGI.
DR GO; GO:0006909; P:phagocytosis; IEA:UniProtKB-KW.
DR GO; GO:0021983; P:pituitary gland development; IMP:MGI.
DR GO; GO:0045766; P:positive regulation of angiogenesis; IMP:MGI.
DR GO; GO:0043536; P:positive regulation of blood vessel endothelial cell migration; ISO:MGI.
DR GO; GO:1903589; P:positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis; ISO:MGI.
DR GO; GO:0090050; P:positive regulation of cell migration involved in sprouting angiogenesis; ISO:MGI.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; ISO:MGI.
DR GO; GO:0045648; P:positive regulation of erythrocyte differentiation; IDA:MGI.
DR GO; GO:0010628; P:positive regulation of gene expression; ISO:MGI.
DR GO; GO:0043306; P:positive regulation of mast cell degranulation; ISO:MGI.
DR GO; GO:0045654; P:positive regulation of megakaryocyte differentiation; IDA:MGI.
DR GO; GO:1902895; P:positive regulation of miRNA transcription; ISO:MGI.
DR GO; GO:0045666; P:positive regulation of neuron differentiation; ISO:MGI.
DR GO; GO:0050766; P:positive regulation of phagocytosis; ISS:UniProtKB.
DR GO; GO:0060100; P:positive regulation of phagocytosis, engulfment; ISO:MGI.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:MGI.
DR GO; GO:2000977; P:regulation of forebrain neuron differentiation; IMP:MGI.
DR GO; GO:0035065; P:regulation of histone acetylation; IDA:MGI.
DR GO; GO:0010725; P:regulation of primitive erythrocyte differentiation; IGI:MGI.
DR GO; GO:0033993; P:response to lipid; IEA:Ensembl.
DR GO; GO:0060872; P:semicircular canal development; IMP:MGI.
DR GO; GO:0035019; P:somatic stem cell population maintenance; IMP:MGI.
DR GO; GO:0060129; P:thyroid-stimulating hormone-secreting cell differentiation; IMP:MGI.
DR GO; GO:0006366; P:transcription by RNA polymerase II; IMP:MGI.
DR GO; GO:0001655; P:urogenital system development; IMP:MGI.
DR GO; GO:0061042; P:vascular wound healing; ISO:MGI.
DR GO; GO:0021514; P:ventral spinal cord interneuron differentiation; IMP:MGI.
DR CDD; cd00202; ZnF_GATA; 2.
DR Gene3D; 3.30.50.10; -; 2.
DR InterPro; IPR029522; GATA-2.
DR InterPro; IPR016374; TF_GATA-2/3.
DR InterPro; IPR039355; Transcription_factor_GATA.
DR InterPro; IPR000679; Znf_GATA.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR10071; PTHR10071; 1.
DR PANTHER; PTHR10071:SF149; PTHR10071:SF149; 1.
DR Pfam; PF00320; GATA; 2.
DR PIRSF; PIRSF003027; TF_GATA-1/2/3; 1.
DR PRINTS; PR00619; GATAZNFINGER.
DR SMART; SM00401; ZnF_GATA; 2.
DR PROSITE; PS00344; GATA_ZN_FINGER_1; 2.
DR PROSITE; PS50114; GATA_ZN_FINGER_2; 2.
PE 1: Evidence at protein level;
KW Activator; DNA-binding; Isopeptide bond; Metal-binding; Methylation;
KW Nucleus; Phagocytosis; Phosphoprotein; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Ubl conjugation; Zinc;
KW Zinc-finger.
FT CHAIN 1..480
FT /note="Endothelial transcription factor GATA-2"
FT /id="PRO_0000083404"
FT ZN_FING 295..319
FT /note="GATA-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00094"
FT ZN_FING 349..373
FT /note="GATA-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00094"
FT REGION 166..208
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 457..480
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 183..199
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 457..471
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 73
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P23769"
FT MOD_RES 86
FT /note="Asymmetric dimethylarginine"
FT /evidence="ECO:0000250|UniProtKB:P23769"
FT MOD_RES 192
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P23769"
FT CROSSLNK 389
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:P23769"
SQ SEQUENCE 480 AA; 50468 MW; 7E0DCE9B53F49C8A CRC64;
MEVAPEQPRW MAHPAVLNAQ HPDSHHPGLA HNYMEPAQLL PPDEVDVFFN HLDSQGNPYY
ANPAHARARV SYSPAHARLT GGQMCRPHLL HSPGLPWLDG GKAALSAAAA HHHSPWTVSP
FSKTPLHPSA AGAPGGPLSV YPGAAGGSGG GSGSSVASLT PTAAHSGSHL FGFPPTPPKE
VSPDPSTTGA ASPASSSAGG SVARGEDKDG VKYQVSLSES MKMEGGSPLR PGLATMGTQP
ATHHPIPTYP SYVPAAAHDY GSSLFHPGGF LGGPASSFTP KQRSKARSCS EGRECVNCGA
TATPLWRRDG TGHYLCNACG LYHKMNGQNR PLIKPKRRLS AARRAGTCCA NCQTTTTTLW
RRNANGDPVC NACGLYYKLH NVNRPLTMKK EGIQTRNRKM SSKSKKSKKG AECFEELSKC
MQEKSPPFSA AALAGHMAPV GHLPPFSHSG HILPTPTPIH PSSSLSFGHP HPSSMVTAMG
