GATA2_RAT
ID GATA2_RAT Reviewed; 480 AA.
AC Q924Y4; Q8VHY4;
DT 29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Endothelial transcription factor GATA-2;
DE AltName: Full=GATA-binding protein 2;
GN Name=Gata2 {ECO:0000312|EMBL:AAK51128.1};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1] {ECO:0000312|EMBL:AAK51128.1}
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley {ECO:0000312|EMBL:AAK51128.1};
RA Itoh T., Itoh A., Pleasure D.;
RL Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000305, ECO:0000312|EMBL:AAL57180.1}
RP NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION IN PHAGOCYTOSIS.
RC STRAIN=Sprague-Dawley {ECO:0000312|EMBL:AAL57180.1};
RC TISSUE=Lung {ECO:0000269|PubMed:12933836};
RX PubMed=12933836; DOI=10.1128/iai.71.9.4943-4952.2003;
RA Lasbury M.E., Tang X., Durant P.J., Lee C.-H.;
RT "Effect of transcription factor GATA-2 on phagocytic activity of alveolar
RT macrophages from Pneumocystis carinii-infected hosts.";
RL Infect. Immun. 71:4943-4952(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Heart, and Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Transcriptional activator which regulates endothelin-1 gene
CC expression in endothelial cells. Binds to the consensus sequence 5'-
CC AGATAG-3' (By similarity). Plays an important role in the regulation of
CC phagocytosis in alveolar macrophages, particularly during P.carinii
CC infection. {ECO:0000250, ECO:0000269|PubMed:12933836}.
CC -!- SUBUNIT: Interacts with BRD3. Interacts with AR and CCAR1.
CC {ECO:0000250|UniProtKB:O09100, ECO:0000250|UniProtKB:P23769}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR EMBL; AY032734; AAK51128.1; -; mRNA.
DR EMBL; AF345897; AAL57180.1; -; mRNA.
DR EMBL; BC061745; AAH61745.1; -; mRNA.
DR RefSeq; NP_254277.1; NM_033442.1.
DR RefSeq; XP_017447968.1; XM_017592479.1.
DR RefSeq; XP_017447969.1; XM_017592480.1.
DR AlphaFoldDB; Q924Y4; -.
DR SMR; Q924Y4; -.
DR BioGRID; 247224; 1.
DR STRING; 10116.ENSRNOP00000017240; -.
DR PhosphoSitePlus; Q924Y4; -.
DR PaxDb; Q924Y4; -.
DR Ensembl; ENSRNOT00000017240; ENSRNOP00000017240; ENSRNOG00000012347.
DR GeneID; 25159; -.
DR KEGG; rno:25159; -.
DR UCSC; RGD:2664; rat.
DR CTD; 2624; -.
DR RGD; 2664; Gata2.
DR eggNOG; KOG1601; Eukaryota.
DR GeneTree; ENSGT00940000156315; -.
DR HOGENOM; CLU_027524_1_0_1; -.
DR InParanoid; Q924Y4; -.
DR OMA; WTVSPFT; -.
DR OrthoDB; 1240204at2759; -.
DR PhylomeDB; Q924Y4; -.
DR TreeFam; TF315391; -.
DR Reactome; R-RNO-8939236; RUNX1 regulates transcription of genes involved in differentiation of HSCs.
DR Reactome; R-RNO-983231; Factors involved in megakaryocyte development and platelet production.
DR PRO; PR:Q924Y4; -.
DR Proteomes; UP000002494; Chromosome 4.
DR Bgee; ENSRNOG00000012347; Expressed in lung and 18 other tissues.
DR ExpressionAtlas; Q924Y4; baseline and differential.
DR Genevisible; Q924Y4; RN.
DR GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IDA:RGD.
DR GO; GO:0005667; C:transcription regulator complex; ISO:RGD.
DR GO; GO:0070742; F:C2H2 zinc finger domain binding; ISO:RGD.
DR GO; GO:0003682; F:chromatin binding; ISO:RGD.
DR GO; GO:0003677; F:DNA binding; ISO:RGD.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:RGD.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISO:RGD.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISO:RGD.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISO:RGD.
DR GO; GO:0061629; F:RNA polymerase II-specific DNA-binding transcription factor binding; ISO:RGD.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:RGD.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:RGD.
DR GO; GO:0001223; F:transcription coactivator binding; ISO:RGD.
DR GO; GO:0001221; F:transcription coregulator binding; ISO:RGD.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0050873; P:brown fat cell differentiation; IEA:Ensembl.
DR GO; GO:0030154; P:cell differentiation; ISO:RGD.
DR GO; GO:0021533; P:cell differentiation in hindbrain; ISO:RGD.
DR GO; GO:0045165; P:cell fate commitment; IBA:GO_Central.
DR GO; GO:0001709; P:cell fate determination; ISO:RGD.
DR GO; GO:0048469; P:cell maturation; ISO:RGD.
DR GO; GO:0021954; P:central nervous system neuron development; ISO:RGD.
DR GO; GO:0090102; P:cochlea development; IEP:RGD.
DR GO; GO:0021902; P:commitment of neuronal cell to specific neuron type in forebrain; ISO:RGD.
DR GO; GO:0060216; P:definitive hemopoiesis; ISO:RGD.
DR GO; GO:0001892; P:embryonic placenta development; ISO:RGD.
DR GO; GO:0035854; P:eosinophil fate commitment; ISO:RGD.
DR GO; GO:0097154; P:GABAergic neuron differentiation; ISO:RGD.
DR GO; GO:0002071; P:glandular epithelial cell maturation; IEA:Ensembl.
DR GO; GO:0002244; P:hematopoietic progenitor cell differentiation; IEA:Ensembl.
DR GO; GO:0061484; P:hematopoietic stem cell homeostasis; IEA:Ensembl.
DR GO; GO:0048873; P:homeostasis of number of cells within a tissue; ISO:RGD.
DR GO; GO:0042472; P:inner ear morphogenesis; ISO:RGD.
DR GO; GO:1903444; P:negative regulation of brown fat cell differentiation; IEA:Ensembl.
DR GO; GO:2000352; P:negative regulation of endothelial cell apoptotic process; ISO:RGD.
DR GO; GO:0045599; P:negative regulation of fat cell differentiation; ISO:RGD.
DR GO; GO:0070345; P:negative regulation of fat cell proliferation; ISO:RGD.
DR GO; GO:0010629; P:negative regulation of gene expression; ISO:RGD.
DR GO; GO:1901533; P:negative regulation of hematopoietic progenitor cell differentiation; IEA:Ensembl.
DR GO; GO:0045650; P:negative regulation of macrophage differentiation; ISO:RGD.
DR GO; GO:0045638; P:negative regulation of myeloid cell differentiation; ISO:RGD.
DR GO; GO:2000178; P:negative regulation of neural precursor cell proliferation; ISO:RGD.
DR GO; GO:0045746; P:negative regulation of Notch signaling pathway; ISO:RGD.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:RGD.
DR GO; GO:0061351; P:neural precursor cell proliferation; IEA:Ensembl.
DR GO; GO:0030182; P:neuron differentiation; ISO:RGD.
DR GO; GO:0048663; P:neuron fate commitment; ISO:RGD.
DR GO; GO:0001764; P:neuron migration; IMP:RGD.
DR GO; GO:0006909; P:phagocytosis; IEA:UniProtKB-KW.
DR GO; GO:0021983; P:pituitary gland development; ISO:RGD.
DR GO; GO:0045766; P:positive regulation of angiogenesis; ISO:RGD.
DR GO; GO:0043536; P:positive regulation of blood vessel endothelial cell migration; ISO:RGD.
DR GO; GO:1903589; P:positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis; ISO:RGD.
DR GO; GO:0090050; P:positive regulation of cell migration involved in sprouting angiogenesis; ISO:RGD.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IMP:RGD.
DR GO; GO:0045648; P:positive regulation of erythrocyte differentiation; ISO:RGD.
DR GO; GO:0010628; P:positive regulation of gene expression; ISO:RGD.
DR GO; GO:0043306; P:positive regulation of mast cell degranulation; IMP:RGD.
DR GO; GO:0045654; P:positive regulation of megakaryocyte differentiation; ISO:RGD.
DR GO; GO:1902895; P:positive regulation of miRNA transcription; ISO:RGD.
DR GO; GO:0045666; P:positive regulation of neuron differentiation; IMP:RGD.
DR GO; GO:0050766; P:positive regulation of phagocytosis; IDA:UniProtKB.
DR GO; GO:0060100; P:positive regulation of phagocytosis, engulfment; IMP:RGD.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IMP:RGD.
DR GO; GO:2000977; P:regulation of forebrain neuron differentiation; ISO:RGD.
DR GO; GO:0035065; P:regulation of histone acetylation; ISO:RGD.
DR GO; GO:0010725; P:regulation of primitive erythrocyte differentiation; ISO:RGD.
DR GO; GO:0033993; P:response to lipid; IEP:RGD.
DR GO; GO:0060872; P:semicircular canal development; ISO:RGD.
DR GO; GO:0035019; P:somatic stem cell population maintenance; ISO:RGD.
DR GO; GO:0060129; P:thyroid-stimulating hormone-secreting cell differentiation; IEA:Ensembl.
DR GO; GO:0006366; P:transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0001655; P:urogenital system development; ISO:RGD.
DR GO; GO:0061042; P:vascular wound healing; ISO:RGD.
DR GO; GO:0021514; P:ventral spinal cord interneuron differentiation; ISO:RGD.
DR CDD; cd00202; ZnF_GATA; 2.
DR Gene3D; 3.30.50.10; -; 2.
DR InterPro; IPR029522; GATA-2.
DR InterPro; IPR016374; TF_GATA-2/3.
DR InterPro; IPR039355; Transcription_factor_GATA.
DR InterPro; IPR000679; Znf_GATA.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR10071; PTHR10071; 1.
DR PANTHER; PTHR10071:SF149; PTHR10071:SF149; 1.
DR Pfam; PF00320; GATA; 2.
DR PIRSF; PIRSF003027; TF_GATA-1/2/3; 1.
DR PRINTS; PR00619; GATAZNFINGER.
DR SMART; SM00401; ZnF_GATA; 2.
DR PROSITE; PS00344; GATA_ZN_FINGER_1; 2.
DR PROSITE; PS50114; GATA_ZN_FINGER_2; 2.
PE 1: Evidence at protein level;
KW Activator; DNA-binding; Isopeptide bond; Metal-binding; Methylation;
KW Nucleus; Phagocytosis; Phosphoprotein; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Ubl conjugation; Zinc;
KW Zinc-finger.
FT CHAIN 1..480
FT /note="Endothelial transcription factor GATA-2"
FT /id="PRO_0000083405"
FT ZN_FING 295..319
FT /note="GATA-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00094"
FT ZN_FING 349..373
FT /note="GATA-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00094"
FT REGION 166..208
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 457..480
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 457..471
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 73
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P23769"
FT MOD_RES 86
FT /note="Asymmetric dimethylarginine"
FT /evidence="ECO:0000250|UniProtKB:P23769"
FT MOD_RES 192
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P23769"
FT CROSSLNK 389
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:P23769"
FT CONFLICT 347
FT /note="T -> S (in Ref. 2; AAL57180)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 480 AA; 50464 MW; 80FBA84AA4258EAD CRC64;
MEVAPEQPRW MAHPAVLNAQ HPDSHHPGLA HNYMEPAQLL PPDEVDVFFN HLDSQGNPYY
ANPAHARARV SYSPAHARLT GGQMCRPHLL HSPGLPWLDG GKAALSAAAA HHHSPWTVSP
FSKTPLHPSA AGAPGGPLSV YPGAAGGSGG GSGSSVASLT PTAAHSGSHL FGFPPTPPKE
VSPDPSTTGA ASPASPSAGG SVARGEDKDG VKYQVSLSES MKMEGGSPLR PGLAPMGTQP
ATHHPIPTYP SYVPASAHEY GSGLFHPGGF LGGPASSFTP KQRSKARSCS EGRECVNCGA
TATPLWRRDG TGHYLCNACG LYHKMNGQNR PLIKPKRRLS AARRAGTCCA NCQTTTTTLW
RRNANGDPVC NACGLYYKLH NVNRPLTMKK EGIQTRNRKM SSKSKKSKKG AECFEELSKC
MQEKSSPFSA AALAGHMAPV GHLPPFSHSG HILPTPTPIH PSSSLSFGHP HPSSMVTAMG
