ID   GATA2_XENLA             Reviewed;         452 AA.
AC   P23770;
DT   01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1991, sequence version 1.
DT   25-MAY-2022, entry version 100.
DE   RecName: Full=GATA-binding factor 2;
DE            Short=GATA-2;
DE   AltName: Full=Transcription factor xGATA-2;
GN   Name=gata2;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC   TISSUE=Neurula;
RX   PubMed=1961730; DOI=10.1073/pnas.88.23.10642;
RA   Zon L.I., Mather C., Burgess S., Bolce M.E., Harland R.M., Orkin S.H.;
RT   "Expression of GATA-binding proteins during embryonic development in
RT   Xenopus laevis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 88:10642-10646(1991).
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- TISSUE SPECIFICITY: Expressed in the developing ventral blood island,
CC       and in the embryonic nervous system. {ECO:0000269|PubMed:1961730}.
CC   -!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically.
CC       Expressed at a low level maternally, and abundantly expressed at stage
CC       11 (mid-gastrula) and thereafter. {ECO:0000269|PubMed:1961730}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; M76564; AAA49723.1; -; mRNA.
DR   PIR; C41602; C41602.
DR   AlphaFoldDB; P23770; -.
DR   SMR; P23770; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0030097; P:hemopoiesis; IEA:InterPro.
DR   CDD; cd00202; ZnF_GATA; 2.
DR   Gene3D; 3.30.50.10; -; 2.
DR   InterPro; IPR029522; GATA-2.
DR   InterPro; IPR016374; TF_GATA-2/3.
DR   InterPro; IPR039355; Transcription_factor_GATA.
DR   InterPro; IPR000679; Znf_GATA.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   PANTHER; PTHR10071; PTHR10071; 1.
DR   PANTHER; PTHR10071:SF149; PTHR10071:SF149; 1.
DR   Pfam; PF00320; GATA; 2.
DR   PIRSF; PIRSF003027; TF_GATA-1/2/3; 1.
DR   PRINTS; PR00619; GATAZNFINGER.
DR   SMART; SM00401; ZnF_GATA; 2.
DR   PROSITE; PS00344; GATA_ZN_FINGER_1; 2.
DR   PROSITE; PS50114; GATA_ZN_FINGER_2; 2.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..452
FT                   /note="GATA-binding factor 2"
FT                   /id="PRO_0000083407"
FT   ZN_FING         267..291
FT                   /note="GATA-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00094"
FT   ZN_FING         321..345
FT                   /note="GATA-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00094"
FT   REGION          130..182
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          426..452
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        137..152
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        153..172
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        426..443
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   452 AA;  48940 MW;  97F4992C8FD71F7A CRC64;
     MEVATDQPRW MAHHAVLNGQ HPDSHHPGLA HNYMEPTQLL PPDEVDVFFN HLDSQGNPYY
     ANSAHARARV SYSQAHARLT GSQMCRPHLL HSPGLPWLES GKTALSAAHH HNPWTVSPFG
     KAPLHPAARG GSLYPGTGSS ACPSSSHSSP HLFGFPPTPP KDVSPDPGPA SPPSSSRLED
     KDSIKYQMSL SEGMKMEGGS PLRSSLAPMG TQCSTHHPIP TYPSYVPAAH DYSSGLFHPG
     SLLGGPASSF TPKQRSKSRS CSEGRECVNC GATATPLWRR DGTGHYLCNA CGLYHKMNGQ
     NRPLIKPKRR LSAARRAGTC CANCQTSTTT LWRRNANGDP VCNACGLYYK LHNVNRPLTM
     KKEGIQTRNR KMSNKSKKNK KGSECFEELS RCMQEKSSPF SAAALASHMA PMGHLAPFSH
     SGHILQTPTP IHPSSSLSFG HPHHSSMVTA MG