GATA3_CHICK
ID GATA3_CHICK Reviewed; 444 AA.
AC P23825; Q6LD66;
DT 01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1991, sequence version 1.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=GATA-binding factor 3;
DE Short=GATA-3;
DE AltName: Full=Transcription factor NF-E1c;
GN Name=GATA3;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2249770; DOI=10.1101/gad.4.10.1650;
RA Yamamoto M., Ko L.J., Leonard M.W., Beug H., Orkin S.H., Engel J.D.;
RT "Activity and tissue-specific expression of the transcription factor NF-E1
RT multigene family.";
RL Genes Dev. 4:1650-1662(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2017177; DOI=10.1128/mcb.11.5.2778-2784.1991;
RA Ko L.J., Yamamoto M., Leonard M.W., George K.M., Ting P., Engel J.D.;
RT "Murine and human T-lymphocyte GATA-3 factors mediate transcription through
RT a cis-regulatory element within the human T-cell receptor delta gene
RT enhancer.";
RL Mol. Cell. Biol. 11:2778-2784(1991).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-18.
RX PubMed=7629014; DOI=10.1093/oxfordjournals.jbchem.a124736;
RA Ishihara H., Engel J.D., Yamamoto M.;
RT "Structure and regulation of the chicken GATA-3 gene.";
RL J. Biochem. 117:499-508(1995).
CC -!- FUNCTION: Transcriptional activator which probably serves as a general
CC switch factor for cell-specific development. It binds to DNA sites with
CC the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of
CC genes.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- TISSUE SPECIFICITY: Expressed only in definitive (adult) erythrocytes
CC within the red cell lineage, and is also abundantly expressed in T-
CC lymphocytes and brain.
CC -!- DOMAIN: Binds DNA via the 2 GATA-type zinc fingers. {ECO:0000250}.
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DR EMBL; X56931; CAA40253.1; -; mRNA.
DR EMBL; S78787; AAD14293.1; -; Genomic_DNA.
DR PIR; B36389; B36389.
DR RefSeq; NP_001008444.1; NM_001008444.1.
DR RefSeq; XP_015148775.1; XM_015293289.1.
DR RefSeq; XP_015148823.1; XM_015293337.1.
DR RefSeq; XP_015148857.1; XM_015293371.1.
DR AlphaFoldDB; P23825; -.
DR SMR; P23825; -.
DR BioGRID; 680262; 1.
DR STRING; 9031.ENSGALP00000010868; -.
DR PaxDb; P23825; -.
DR Ensembl; ENSGALT00000049267; ENSGALP00000058144; ENSGALG00000029270.
DR Ensembl; ENSGALT00000099385; ENSGALP00000068882; ENSGALG00000029270.
DR GeneID; 419106; -.
DR KEGG; gga:419106; -.
DR CTD; 2625; -.
DR VEuPathDB; HostDB:geneid_419106; -.
DR eggNOG; KOG1601; Eukaryota.
DR GeneTree; ENSGT00940000159247; -.
DR HOGENOM; CLU_027524_1_0_1; -.
DR InParanoid; P23825; -.
DR OMA; HSYMDPT; -.
DR OrthoDB; 1240204at2759; -.
DR PhylomeDB; P23825; -.
DR Reactome; R-GGA-8939236; RUNX1 regulates transcription of genes involved in differentiation of HSCs.
DR Reactome; R-GGA-9018519; Estrogen-dependent gene expression.
DR Reactome; R-GGA-983231; Factors involved in megakaryocyte development and platelet production.
DR PRO; PR:P23825; -.
DR Proteomes; UP000000539; Chromosome 1.
DR Bgee; ENSGALG00000029270; Expressed in granulocyte and 10 other tissues.
DR GO; GO:0000785; C:chromatin; ISS:UniProtKB.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0000987; F:cis-regulatory region sequence-specific DNA binding; ISS:UniProtKB.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISS:UniProtKB.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0070888; F:E-box binding; ISS:UniProtKB.
DR GO; GO:0071837; F:HMG box domain binding; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0005134; F:interleukin-2 receptor binding; IEA:Ensembl.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0061629; F:RNA polymerase II-specific DNA-binding transcription factor binding; IEA:Ensembl.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IDA:UniProtKB.
DR GO; GO:0001223; F:transcription coactivator binding; IPI:BHF-UCL.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0048646; P:anatomical structure formation involved in morphogenesis; ISS:UniProtKB.
DR GO; GO:0003180; P:aortic valve morphogenesis; ISS:UniProtKB.
DR GO; GO:0007411; P:axon guidance; NAS:UniProtKB.
DR GO; GO:0061290; P:canonical Wnt signaling pathway involved in metanephric kidney development; ISS:UniProtKB.
DR GO; GO:0003215; P:cardiac right ventricle morphogenesis; ISS:UniProtKB.
DR GO; GO:0045165; P:cell fate commitment; IBA:GO_Central.
DR GO; GO:0001709; P:cell fate determination; ISS:UniProtKB.
DR GO; GO:0048469; P:cell maturation; IEA:Ensembl.
DR GO; GO:0008283; P:cell population proliferation; IEA:Ensembl.
DR GO; GO:0071773; P:cellular response to BMP stimulus; IEA:Ensembl.
DR GO; GO:0035457; P:cellular response to interferon-alpha; IEA:Ensembl.
DR GO; GO:0071353; P:cellular response to interleukin-4; IEA:Ensembl.
DR GO; GO:0071356; P:cellular response to tumor necrosis factor; IEA:Ensembl.
DR GO; GO:0006338; P:chromatin remodeling; IEA:Ensembl.
DR GO; GO:0048589; P:developmental growth; IEA:Ensembl.
DR GO; GO:0043583; P:ear development; ISS:UniProtKB.
DR GO; GO:0035162; P:embryonic hemopoiesis; IEA:Ensembl.
DR GO; GO:0048568; P:embryonic organ development; IBA:GO_Central.
DR GO; GO:0030218; P:erythrocyte differentiation; IEA:Ensembl.
DR GO; GO:0006959; P:humoral immune response; IEA:Ensembl.
DR GO; GO:0002520; P:immune system development; IBA:GO_Central.
DR GO; GO:0042491; P:inner ear auditory receptor cell differentiation; IEP:UniProtKB.
DR GO; GO:0042472; P:inner ear morphogenesis; IEA:Ensembl.
DR GO; GO:0001822; P:kidney development; ISS:UniProtKB.
DR GO; GO:0002088; P:lens development in camera-type eye; IEA:Ensembl.
DR GO; GO:0072676; P:lymphocyte migration; ISS:UniProtKB.
DR GO; GO:0008584; P:male gonad development; ISS:UniProtKB.
DR GO; GO:0060374; P:mast cell differentiation; IEA:Ensembl.
DR GO; GO:0060231; P:mesenchymal to epithelial transition; ISS:UniProtKB.
DR GO; GO:0001823; P:mesonephros development; ISS:UniProtKB.
DR GO; GO:0030101; P:natural killer cell activation; IEA:Ensembl.
DR GO; GO:0045786; P:negative regulation of cell cycle; ISS:UniProtKB.
DR GO; GO:2000146; P:negative regulation of cell motility; ISS:UniProtKB.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; ISS:UniProtKB.
DR GO; GO:2000607; P:negative regulation of cell proliferation involved in mesonephros development; ISS:UniProtKB.
DR GO; GO:1901536; P:negative regulation of DNA demethylation; IEA:Ensembl.
DR GO; GO:2000352; P:negative regulation of endothelial cell apoptotic process; ISS:UniProtKB.
DR GO; GO:0010719; P:negative regulation of epithelial to mesenchymal transition; IEA:Ensembl.
DR GO; GO:0045599; P:negative regulation of fat cell differentiation; ISS:UniProtKB.
DR GO; GO:2000703; P:negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation; ISS:UniProtKB.
DR GO; GO:2000734; P:negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation; ISS:UniProtKB.
DR GO; GO:0050728; P:negative regulation of inflammatory response; ISS:UniProtKB.
DR GO; GO:0032689; P:negative regulation of interferon-gamma production; IEA:Ensembl.
DR GO; GO:0032703; P:negative regulation of interleukin-2 production; IEA:Ensembl.
DR GO; GO:0033600; P:negative regulation of mammary gland epithelial cell proliferation; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IMP:UniProtKB.
DR GO; GO:0072179; P:nephric duct formation; ISS:UniProtKB.
DR GO; GO:0072178; P:nephric duct morphogenesis; ISS:UniProtKB.
DR GO; GO:0001764; P:neuron migration; IEA:Ensembl.
DR GO; GO:0042421; P:norepinephrine biosynthetic process; ISS:UniProtKB.
DR GO; GO:0071599; P:otic vesicle development; IEA:Ensembl.
DR GO; GO:0060017; P:parathyroid gland development; IEA:Ensembl.
DR GO; GO:0035898; P:parathyroid hormone secretion; IEA:Ensembl.
DR GO; GO:0060037; P:pharyngeal system development; ISS:UniProtKB.
DR GO; GO:0014065; P:phosphatidylinositol 3-kinase signaling; ISS:UniProtKB.
DR GO; GO:0010595; P:positive regulation of endothelial cell migration; ISS:UniProtKB.
DR GO; GO:0071442; P:positive regulation of histone H3-K14 acetylation; IEA:Ensembl.
DR GO; GO:2000617; P:positive regulation of histone H3-K9 acetylation; IEA:Ensembl.
DR GO; GO:0032736; P:positive regulation of interleukin-13 production; ISS:UniProtKB.
DR GO; GO:0032753; P:positive regulation of interleukin-4 production; ISS:UniProtKB.
DR GO; GO:0032754; P:positive regulation of interleukin-5 production; ISS:UniProtKB.
DR GO; GO:1902895; P:positive regulation of miRNA transcription; IEA:Ensembl.
DR GO; GO:0051897; P:positive regulation of protein kinase B signaling; ISS:UniProtKB.
DR GO; GO:0009967; P:positive regulation of signal transduction; ISS:UniProtKB.
DR GO; GO:0045582; P:positive regulation of T cell differentiation; ISS:UniProtKB.
DR GO; GO:2000553; P:positive regulation of T-helper 2 cell cytokine production; IEA:Ensembl.
DR GO; GO:2000611; P:positive regulation of thyroid hormone generation; ISS:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:2000679; P:positive regulation of transcription regulatory region DNA binding; ISS:UniProtKB.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IMP:UniProtKB.
DR GO; GO:0072107; P:positive regulation of ureteric bud formation; ISS:UniProtKB.
DR GO; GO:0009791; P:post-embryonic development; IEA:Ensembl.
DR GO; GO:0002572; P:pro-T cell differentiation; IEA:Ensembl.
DR GO; GO:2000683; P:regulation of cellular response to X-ray; ISS:UniProtKB.
DR GO; GO:0001817; P:regulation of cytokine production; ISS:UniProtKB.
DR GO; GO:0030856; P:regulation of epithelial cell differentiation; IBA:GO_Central.
DR GO; GO:2000114; P:regulation of establishment of cell polarity; IEA:Ensembl.
DR GO; GO:0061085; P:regulation of histone H3-K27 methylation; IEA:Ensembl.
DR GO; GO:0051569; P:regulation of histone H3-K4 methylation; IEA:Ensembl.
DR GO; GO:0072182; P:regulation of nephron tubule epithelial cell differentiation; ISS:UniProtKB.
DR GO; GO:0043523; P:regulation of neuron apoptotic process; IEA:Ensembl.
DR GO; GO:0010975; P:regulation of neuron projection development; IEA:Ensembl.
DR GO; GO:0045622; P:regulation of T-helper cell differentiation; IEA:Ensembl.
DR GO; GO:0043627; P:response to estrogen; IEA:Ensembl.
DR GO; GO:0009615; P:response to virus; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; ISS:UniProtKB.
DR GO; GO:0048485; P:sympathetic nervous system development; ISS:UniProtKB.
DR GO; GO:0050852; P:T cell receptor signaling pathway; ISS:UniProtKB.
DR GO; GO:0045064; P:T-helper 2 cell differentiation; IEA:Ensembl.
DR GO; GO:0045061; P:thymic T cell selection; IEA:Ensembl.
DR GO; GO:0048538; P:thymus development; IEA:Ensembl.
DR GO; GO:0031929; P:TOR signaling; ISS:UniProtKB.
DR GO; GO:0006366; P:transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0035799; P:ureter maturation; IEA:Ensembl.
DR GO; GO:0072197; P:ureter morphogenesis; IEA:Ensembl.
DR GO; GO:0060676; P:ureteric bud formation; ISS:UniProtKB.
DR GO; GO:0060065; P:uterus development; ISS:UniProtKB.
DR GO; GO:0003281; P:ventricular septum development; ISS:UniProtKB.
DR CDD; cd00202; ZnF_GATA; 2.
DR Gene3D; 3.30.50.10; -; 2.
DR InterPro; IPR029521; GATA-3.
DR InterPro; IPR016374; TF_GATA-2/3.
DR InterPro; IPR039355; Transcription_factor_GATA.
DR InterPro; IPR000679; Znf_GATA.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR10071; PTHR10071; 1.
DR PANTHER; PTHR10071:SF106; PTHR10071:SF106; 1.
DR Pfam; PF00320; GATA; 2.
DR PIRSF; PIRSF003027; TF_GATA-1/2/3; 1.
DR PRINTS; PR00619; GATAZNFINGER.
DR SMART; SM00401; ZnF_GATA; 2.
DR PROSITE; PS00344; GATA_ZN_FINGER_1; 2.
DR PROSITE; PS50114; GATA_ZN_FINGER_2; 2.
PE 2: Evidence at transcript level;
KW Activator; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..444
FT /note="GATA-binding factor 3"
FT /id="PRO_0000083410"
FT ZN_FING 264..288
FT /note="GATA-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00094"
FT ZN_FING 318..342
FT /note="GATA-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00094"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 123..181
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 195..215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 362..390
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 413..444
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 123..149
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 413..435
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 444 AA; 48197 MW; D8A6858B0CD953E1 CRC64;
MEVSTDQPRW VSHHHPAVLN GQHPDSHHPT LGHTYMDPTQ YPLAEEVDVL FNIDGQGNPV
PPYYGNSVRA TVQRYPTAHH GSQVCRPPLL HGSLPWLDGS KALSSHHSAS PWNLSPFSKT
SIHHSSPGPL SVYPPASSST LSAGHSSPHL FTFPPTPPKD VSPDPSISTP GSTGSTRQDE
KECIKYQVSL ADTMKLESSH SRSSMASLGG ATSSAHHPIT TYPPYVPEYS SGLFPPSSLL
GGSPTGFGCK SRPKARSSTE GRECVNCGAT STPLWRRDGT GHYLCNACGL YHKMNGQNRP
LIKPKRRLSA ARRAGTSCAN CQTTTTTLWR RNANGDPVCN ACGLYYKLHN INRPLTMKKE
GIQTRNRKMS SKSKKCKKVH DNLEDFPKSS SFNPAALSRH MSSISHISPF SHSSHMLTTP
TPMHPPSSLS FGPHHPSSMV TAMG
