GATA3_MOUSE
ID GATA3_MOUSE Reviewed; 443 AA.
AC P23772;
DT 01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1991, sequence version 1.
DT 03-AUG-2022, entry version 184.
DE RecName: Full=Trans-acting T-cell-specific transcription factor GATA-3;
DE AltName: Full=GATA-binding factor 3;
GN Name=Gata3; Synonyms=Gata-3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2017177; DOI=10.1128/mcb.11.5.2778-2784.1991;
RA Ko L.J., Yamamoto M., Leonard M.W., George K.M., Ting P., Engel J.D.;
RT "Murine and human T-lymphocyte GATA-3 factors mediate transcription through
RT a cis-regulatory element within the human T-cell receptor delta gene
RT enhancer.";
RL Mol. Cell. Biol. 11:2778-2784(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP INTERACTION WITH TBX21, AND SUBCELLULAR LOCATION.
RX PubMed=15662016; DOI=10.1126/science.1103336;
RA Hwang E.S., Szabo S.J., Schwartzberg P.L., Glimcher L.H.;
RT "T helper cell fate specified by kinase-mediated interaction of T-bet with
RT GATA-3.";
RL Science 307:430-433(2005).
RN [4]
RP FUNCTION, YXKXHXXXRP MOTIF, AND MUTAGENESIS OF TYR-344; LYS-346; HIS-348;
RP ARG-352 AND PRO-353.
RX PubMed=17056504; DOI=10.4049/jimmunol.177.9.5801;
RA Shinnakasu R., Yamashita M., Shinoda K., Endo Y., Hosokawa H., Hasegawa A.,
RA Ikemizu S., Nakayama T.;
RT "Critical YxKxHxxxRP motif in the C-terminal region of GATA3 for its DNA
RT binding and function.";
RL J. Immunol. 177:5801-5810(2006).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-161, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Lung;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [6]
RP INTERACTION WITH TBX21.
RX PubMed=21690296; DOI=10.1128/mcb.05383-11;
RA Chen A., Lee S.M., Gao B., Shannon S., Zhu Z., Fang D.;
RT "c-Abl-mediated tyrosine phosphorylation of the T-bet DNA-binding domain
RT regulates CD4+ T-cell differentiation and allergic lung inflammation.";
RL Mol. Cell. Biol. 31:3445-3456(2011).
RN [7]
RP INTERACTION WITH TBX21.
RX PubMed=23616576; DOI=10.4049/jimmunol.1203403;
RA Jang E.J., Park H.R., Hong J.H., Hwang E.S.;
RT "Lysine 313 of T-box is crucial for modulation of protein stability, DNA
RT binding, and threonine phosphorylation of T-bet.";
RL J. Immunol. 190:5764-5770(2013).
RN [8]
RP FUNCTION.
RX PubMed=31175139; DOI=10.1158/2326-6066.cir-18-0562;
RA Spinner C.A., Lamsoul I., Metais A., Febrissy C., Moog-Lutz C., Lutz P.G.;
RT "The E3 Ubiquitin Ligase Asb2alpha in T Helper 2 Cells Negatively Regulates
RT Antitumor Immunity in Colorectal Cancer.";
RL Cancer Immunol. Res. 7:1332-1344(2019).
RN [9]
RP X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 308-370 IN COMPLEX WITH DNA, AND
RP DOMAIN.
RX PubMed=18621058; DOI=10.1016/j.jmb.2008.06.072;
RA Bates D.L., Chen Y., Kim G., Guo L., Chen L.;
RT "Crystal structures of multiple GATA zinc fingers bound to DNA reveal new
RT insights into DNA recognition and self-association by GATA.";
RL J. Mol. Biol. 381:1292-1306(2008).
CC -!- FUNCTION: Transcriptional activator which binds to the enhancer of the
CC T-cell receptor alpha and delta genes. Binds to the consensus sequence
CC 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process
CC following immune and inflammatory responses. Positively regulates ASB2
CC expression (PubMed:31175139). {ECO:0000269|PubMed:17056504,
CC ECO:0000269|PubMed:31175139}.
CC -!- SUBUNIT: Interacts with TBX21 ('Tyr-525' phosphorylated form).
CC {ECO:0000269|PubMed:15662016, ECO:0000269|PubMed:21690296,
CC ECO:0000269|PubMed:23616576}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15662016}.
CC -!- TISSUE SPECIFICITY: T-cell specific.
CC -!- DOMAIN: Binds DNA via the 2 GATA-type zinc fingers. Each zinc finger
CC may bind either adjacent sites in a palindromic motif, or a different
CC DNA molecule allowing looping and long-range gene regulation (By
CC similarity). {ECO:0000250}.
CC -!- DOMAIN: The YxKxHxxxRP motif is critical for DNA-binding and function.
CC {ECO:0000269|PubMed:18621058}.
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DR EMBL; X55123; CAA38917.1; -; mRNA.
DR EMBL; BC062915; AAH62915.1; -; mRNA.
DR CCDS; CCDS15674.1; -.
DR PIR; B39794; B39794.
DR RefSeq; NP_032117.1; NM_008091.3.
DR RefSeq; XP_006497417.1; XM_006497354.1.
DR PDB; 3DFV; X-ray; 3.10 A; C/D=308-370.
DR PDB; 3DFX; X-ray; 2.70 A; A/B=308-370.
DR PDBsum; 3DFV; -.
DR PDBsum; 3DFX; -.
DR AlphaFoldDB; P23772; -.
DR SMR; P23772; -.
DR BioGRID; 199840; 9.
DR DIP; DIP-29712N; -.
DR IntAct; P23772; 4.
DR STRING; 10090.ENSMUSP00000100041; -.
DR iPTMnet; P23772; -.
DR PhosphoSitePlus; P23772; -.
DR jPOST; P23772; -.
DR PaxDb; P23772; -.
DR PRIDE; P23772; -.
DR ProteomicsDB; 271635; -.
DR Antibodypedia; 11113; 1043 antibodies from 49 providers.
DR DNASU; 14462; -.
DR Ensembl; ENSMUST00000102976; ENSMUSP00000100041; ENSMUSG00000015619.
DR GeneID; 14462; -.
DR KEGG; mmu:14462; -.
DR UCSC; uc008ihf.1; mouse.
DR CTD; 2625; -.
DR MGI; MGI:95663; Gata3.
DR VEuPathDB; HostDB:ENSMUSG00000015619; -.
DR eggNOG; KOG1601; Eukaryota.
DR GeneTree; ENSGT00940000159247; -.
DR HOGENOM; CLU_027524_1_0_1; -.
DR InParanoid; P23772; -.
DR OMA; HSYMDPT; -.
DR OrthoDB; 1240204at2759; -.
DR PhylomeDB; P23772; -.
DR TreeFam; TF315391; -.
DR Reactome; R-MMU-5689880; Ub-specific processing proteases.
DR Reactome; R-MMU-8939236; RUNX1 regulates transcription of genes involved in differentiation of HSCs.
DR Reactome; R-MMU-9018519; Estrogen-dependent gene expression.
DR Reactome; R-MMU-983231; Factors involved in megakaryocyte development and platelet production.
DR BioGRID-ORCS; 14462; 2 hits in 77 CRISPR screens.
DR ChiTaRS; Gata3; mouse.
DR EvolutionaryTrace; P23772; -.
DR PRO; PR:P23772; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; P23772; protein.
DR Bgee; ENSMUSG00000015619; Expressed in urinary bladder urothelium and 213 other tissues.
DR ExpressionAtlas; P23772; baseline and differential.
DR Genevisible; P23772; MM.
DR GO; GO:0000785; C:chromatin; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0000987; F:cis-regulatory region sequence-specific DNA binding; IDA:UniProtKB.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISS:UniProtKB.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; ISS:UniProtKB.
DR GO; GO:0070888; F:E-box binding; ISS:UniProtKB.
DR GO; GO:0071837; F:HMG box domain binding; ISO:MGI.
DR GO; GO:0042802; F:identical protein binding; IPI:MGI.
DR GO; GO:0005134; F:interleukin-2 receptor binding; IPI:MGI.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:GO_Central.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IDA:MGI.
DR GO; GO:0061629; F:RNA polymerase II-specific DNA-binding transcription factor binding; ISO:MGI.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:MGI.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; ISO:MGI.
DR GO; GO:0001223; F:transcription coactivator binding; IPI:BHF-UCL.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0048646; P:anatomical structure formation involved in morphogenesis; IMP:MGI.
DR GO; GO:0003180; P:aortic valve morphogenesis; IMP:UniProtKB.
DR GO; GO:0007411; P:axon guidance; IMP:MGI.
DR GO; GO:0061290; P:canonical Wnt signaling pathway involved in metanephric kidney development; IMP:UniProtKB.
DR GO; GO:0003215; P:cardiac right ventricle morphogenesis; IMP:UniProtKB.
DR GO; GO:0045165; P:cell fate commitment; IBA:GO_Central.
DR GO; GO:0001709; P:cell fate determination; IDA:MGI.
DR GO; GO:0048469; P:cell maturation; IMP:MGI.
DR GO; GO:0000902; P:cell morphogenesis; IMP:MGI.
DR GO; GO:0008283; P:cell population proliferation; IMP:MGI.
DR GO; GO:0071773; P:cellular response to BMP stimulus; IDA:MGI.
DR GO; GO:0071345; P:cellular response to cytokine stimulus; IDA:MGI.
DR GO; GO:0035457; P:cellular response to interferon-alpha; IEA:Ensembl.
DR GO; GO:0071353; P:cellular response to interleukin-4; IDA:MGI.
DR GO; GO:0071356; P:cellular response to tumor necrosis factor; IEA:Ensembl.
DR GO; GO:0006338; P:chromatin remodeling; IDA:MGI.
DR GO; GO:0090102; P:cochlea development; IEA:Ensembl.
DR GO; GO:0048589; P:developmental growth; IMP:MGI.
DR GO; GO:0043583; P:ear development; ISS:UniProtKB.
DR GO; GO:0035162; P:embryonic hemopoiesis; IMP:MGI.
DR GO; GO:0048568; P:embryonic organ development; IMP:MGI.
DR GO; GO:0030218; P:erythrocyte differentiation; IDA:MGI.
DR GO; GO:0010467; P:gene expression; IMP:MGI.
DR GO; GO:0048872; P:homeostasis of number of cells; IMP:MGI.
DR GO; GO:0006959; P:humoral immune response; IMP:MGI.
DR GO; GO:0002520; P:immune system development; IBA:GO_Central.
DR GO; GO:0001701; P:in utero embryonic development; IMP:MGI.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0042472; P:inner ear morphogenesis; IMP:MGI.
DR GO; GO:0001822; P:kidney development; ISO:MGI.
DR GO; GO:0002088; P:lens development in camera-type eye; IMP:MGI.
DR GO; GO:0072676; P:lymphocyte migration; ISS:UniProtKB.
DR GO; GO:0008584; P:male gonad development; IMP:UniProtKB.
DR GO; GO:0060374; P:mast cell differentiation; IDA:MGI.
DR GO; GO:0060231; P:mesenchymal to epithelial transition; ISS:UniProtKB.
DR GO; GO:0001823; P:mesonephros development; IMP:MGI.
DR GO; GO:0030101; P:natural killer cell activation; IMP:MGI.
DR GO; GO:0045786; P:negative regulation of cell cycle; IMP:MGI.
DR GO; GO:2000146; P:negative regulation of cell motility; ISS:UniProtKB.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IMP:MGI.
DR GO; GO:2000607; P:negative regulation of cell proliferation involved in mesonephros development; IMP:UniProtKB.
DR GO; GO:1901536; P:negative regulation of DNA demethylation; IDA:MGI.
DR GO; GO:2000352; P:negative regulation of endothelial cell apoptotic process; ISS:UniProtKB.
DR GO; GO:0010719; P:negative regulation of epithelial to mesenchymal transition; ISO:MGI.
DR GO; GO:0045599; P:negative regulation of fat cell differentiation; ISS:UniProtKB.
DR GO; GO:2000703; P:negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation; IMP:UniProtKB.
DR GO; GO:0010629; P:negative regulation of gene expression; IMP:MGI.
DR GO; GO:2000734; P:negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation; IMP:UniProtKB.
DR GO; GO:0050728; P:negative regulation of inflammatory response; ISS:UniProtKB.
DR GO; GO:0032689; P:negative regulation of interferon-gamma production; IDA:MGI.
DR GO; GO:0032703; P:negative regulation of interleukin-2 production; IDA:MGI.
DR GO; GO:0033600; P:negative regulation of mammary gland epithelial cell proliferation; ISO:MGI.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:MGI.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0072179; P:nephric duct formation; IMP:UniProtKB.
DR GO; GO:0072178; P:nephric duct morphogenesis; IMP:UniProtKB.
DR GO; GO:0007399; P:nervous system development; IMP:MGI.
DR GO; GO:0030182; P:neuron differentiation; IMP:MGI.
DR GO; GO:0001764; P:neuron migration; IMP:MGI.
DR GO; GO:0042421; P:norepinephrine biosynthetic process; IMP:MGI.
DR GO; GO:0071599; P:otic vesicle development; IMP:MGI.
DR GO; GO:0060017; P:parathyroid gland development; IMP:MGI.
DR GO; GO:0035898; P:parathyroid hormone secretion; IMP:MGI.
DR GO; GO:0060037; P:pharyngeal system development; IMP:UniProtKB.
DR GO; GO:0014065; P:phosphatidylinositol 3-kinase signaling; IMP:UniProtKB.
DR GO; GO:0045597; P:positive regulation of cell differentiation; IMP:MGI.
DR GO; GO:0001819; P:positive regulation of cytokine production; IDA:MGI.
DR GO; GO:0010595; P:positive regulation of endothelial cell migration; ISS:UniProtKB.
DR GO; GO:0010628; P:positive regulation of gene expression; IGI:MGI.
DR GO; GO:0071442; P:positive regulation of histone H3-K14 acetylation; IDA:MGI.
DR GO; GO:2000617; P:positive regulation of histone H3-K9 acetylation; IDA:MGI.
DR GO; GO:0032736; P:positive regulation of interleukin-13 production; IMP:MGI.
DR GO; GO:0032753; P:positive regulation of interleukin-4 production; IDA:MGI.
DR GO; GO:0032754; P:positive regulation of interleukin-5 production; IMP:MGI.
DR GO; GO:1902895; P:positive regulation of miRNA transcription; ISO:MGI.
DR GO; GO:0051897; P:positive regulation of protein kinase B signaling; ISS:UniProtKB.
DR GO; GO:0009967; P:positive regulation of signal transduction; ISS:UniProtKB.
DR GO; GO:0045582; P:positive regulation of T cell differentiation; IDA:UniProtKB.
DR GO; GO:2000553; P:positive regulation of T-helper 2 cell cytokine production; IMP:MGI.
DR GO; GO:2000611; P:positive regulation of thyroid hormone generation; ISS:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:MGI.
DR GO; GO:2000679; P:positive regulation of transcription regulatory region DNA binding; IMP:UniProtKB.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:UniProtKB.
DR GO; GO:0072107; P:positive regulation of ureteric bud formation; IMP:UniProtKB.
DR GO; GO:0009791; P:post-embryonic development; IMP:MGI.
DR GO; GO:0002572; P:pro-T cell differentiation; IMP:MGI.
DR GO; GO:2000683; P:regulation of cellular response to X-ray; ISS:UniProtKB.
DR GO; GO:0001817; P:regulation of cytokine production; IDA:MGI.
DR GO; GO:0030856; P:regulation of epithelial cell differentiation; IBA:GO_Central.
DR GO; GO:2000114; P:regulation of establishment of cell polarity; IDA:MGI.
DR GO; GO:0061085; P:regulation of histone H3-K27 methylation; IDA:MGI.
DR GO; GO:0051569; P:regulation of histone H3-K4 methylation; IDA:MGI.
DR GO; GO:0072182; P:regulation of nephron tubule epithelial cell differentiation; IMP:UniProtKB.
DR GO; GO:0043523; P:regulation of neuron apoptotic process; IMP:MGI.
DR GO; GO:0010975; P:regulation of neuron projection development; IMP:MGI.
DR GO; GO:0045622; P:regulation of T-helper cell differentiation; IMP:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IDA:MGI.
DR GO; GO:0043627; P:response to estrogen; IEA:Ensembl.
DR GO; GO:0045471; P:response to ethanol; IEA:Ensembl.
DR GO; GO:0010332; P:response to gamma radiation; IEA:Ensembl.
DR GO; GO:0009615; P:response to virus; IEA:Ensembl.
DR GO; GO:0009410; P:response to xenobiotic stimulus; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IMP:UniProtKB.
DR GO; GO:0048485; P:sympathetic nervous system development; IMP:MGI.
DR GO; GO:0030217; P:T cell differentiation; IDA:MGI.
DR GO; GO:0033077; P:T cell differentiation in thymus; IMP:MGI.
DR GO; GO:0050852; P:T cell receptor signaling pathway; IDA:UniProtKB.
DR GO; GO:0045064; P:T-helper 2 cell differentiation; IDA:MGI.
DR GO; GO:0045061; P:thymic T cell selection; IMP:MGI.
DR GO; GO:0048538; P:thymus development; IMP:MGI.
DR GO; GO:0031929; P:TOR signaling; IMP:UniProtKB.
DR GO; GO:0006366; P:transcription by RNA polymerase II; IMP:MGI.
DR GO; GO:0001806; P:type IV hypersensitivity; IEA:Ensembl.
DR GO; GO:0035799; P:ureter maturation; IMP:MGI.
DR GO; GO:0072197; P:ureter morphogenesis; IGI:MGI.
DR GO; GO:0060676; P:ureteric bud formation; IMP:UniProtKB.
DR GO; GO:0060065; P:uterus development; IMP:UniProtKB.
DR GO; GO:0003281; P:ventricular septum development; IMP:UniProtKB.
DR CDD; cd00202; ZnF_GATA; 2.
DR Gene3D; 3.30.50.10; -; 2.
DR InterPro; IPR029521; GATA-3.
DR InterPro; IPR016374; TF_GATA-2/3.
DR InterPro; IPR039355; Transcription_factor_GATA.
DR InterPro; IPR000679; Znf_GATA.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR10071; PTHR10071; 1.
DR PANTHER; PTHR10071:SF106; PTHR10071:SF106; 1.
DR Pfam; PF00320; GATA; 2.
DR PIRSF; PIRSF003027; TF_GATA-1/2/3; 1.
DR PRINTS; PR00619; GATAZNFINGER.
DR SMART; SM00401; ZnF_GATA; 2.
DR PROSITE; PS00344; GATA_ZN_FINGER_1; 2.
DR PROSITE; PS50114; GATA_ZN_FINGER_2; 2.
PE 1: Evidence at protein level;
KW 3D-structure; Activator; DNA-binding; Immunity; Innate immunity;
KW Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..443
FT /note="Trans-acting T-cell-specific transcription factor
FT GATA-3"
FT /id="PRO_0000083409"
FT ZN_FING 263..287
FT /note="GATA-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00094"
FT ZN_FING 317..341
FT /note="GATA-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00094"
FT REGION 1..257
FT /note="Interaction with TBX21"
FT /evidence="ECO:0000269|PubMed:15662016"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 143..180
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 193..214
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 288..316
FT /note="Flexible linker"
FT /evidence="ECO:0000250"
FT REGION 412..443
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 344..353
FT /note="YxKxHxxxRP"
FT MOD_RES 114
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P23771"
FT MOD_RES 161
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MUTAGEN 344
FT /note="Y->A: Dramatically decreased Th2 cell
FT differentiation."
FT /evidence="ECO:0000269|PubMed:17056504"
FT MUTAGEN 346
FT /note="K->A: Moderately decreased Th2 cell
FT differentiation."
FT /evidence="ECO:0000269|PubMed:17056504"
FT MUTAGEN 348
FT /note="H->A: Dramatically decreased Th2 cell
FT differentiation."
FT /evidence="ECO:0000269|PubMed:17056504"
FT MUTAGEN 352
FT /note="R->A: Fails to induce Th2 cytokine production."
FT /evidence="ECO:0000269|PubMed:17056504"
FT MUTAGEN 353
FT /note="P->A,K: Fails to induce Th2 cytokine production."
FT /evidence="ECO:0000269|PubMed:17056504"
FT TURN 318..320
FT /evidence="ECO:0007829|PDB:3DFX"
FT STRAND 326..330
FT /evidence="ECO:0007829|PDB:3DFV"
FT STRAND 336..338
FT /evidence="ECO:0007829|PDB:3DFV"
FT HELIX 339..348
FT /evidence="ECO:0007829|PDB:3DFX"
FT HELIX 354..356
FT /evidence="ECO:0007829|PDB:3DFX"
SQ SEQUENCE 443 AA; 47968 MW; 980E58FB9872E560 CRC64;
MEVTADQPRW VSHHHPAVLN GQHPDTHHPG LGHSYMEAQY PLTEEVDVLF NIDGQGNHVP
SYYGNSVRAT VQRYPPTHHG SQVCRPPLLH GSLPWLDGGK ALSSHHTASP WNLSPFSKTS
IHHGSPGPLS VYPPASSSSL AAGHSSPHLF TFPPTPPKDV SPDPSLSTPG SAGSARQDEK
ECLKYQVQLP DSMKLETSHS RGSMTTLGGA SSSAHHPITT YPPYVPEYSS GLFPPSSLLG
GSPTGFGCKS RPKARSSTEG RECVNCGATS TPLWRRDGTG HYLCNACGLY HKMNGQNRPL
IKPKRRLSAA RRAGTSCANC QTTTTTLWRR NANGDPVCNA CGLYYKLHNI NRPLTMKKEG
IQTRNRKMSS KSKKCKKVHD ALEDFPKSSS FNPAALSRHM SSLSHISPFS HSSHMLTTPT
PMHPPSGLSF GPHHPSSMVT AMG
