ID   GATA3_XENLA             Reviewed;         435 AA.
AC   P23773;
DT   01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1991, sequence version 1.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=GATA-binding factor 3;
DE   AltName: Full=Transcription factor xGATA-3;
GN   Name=gata3;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC   TISSUE=Neurula;
RX   PubMed=1961730; DOI=10.1073/pnas.88.23.10642;
RA   Zon L.I., Mather C., Burgess S., Bolce M.E., Harland R.M., Orkin S.H.;
RT   "Expression of GATA-binding proteins during embryonic development in
RT   Xenopus laevis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 88:10642-10646(1991).
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- TISSUE SPECIFICITY: Expressed in the embryonic nervous system and in
CC       adult reticulocytes. {ECO:0000269|PubMed:1961730}.
CC   -!- DEVELOPMENTAL STAGE: Expressed zygotically by embryonic stage 11 (mid-
CC       gastrula). {ECO:0000269|PubMed:1961730}.
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DR   EMBL; M76565; AAA49724.1; -; mRNA.
DR   PIR; D41602; D41602.
DR   AlphaFoldDB; P23773; -.
DR   SMR; P23773; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0045582; P:positive regulation of T cell differentiation; IEA:InterPro.
DR   CDD; cd00202; ZnF_GATA; 2.
DR   Gene3D; 3.30.50.10; -; 2.
DR   InterPro; IPR029521; GATA-3.
DR   InterPro; IPR016374; TF_GATA-2/3.
DR   InterPro; IPR039355; Transcription_factor_GATA.
DR   InterPro; IPR000679; Znf_GATA.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   PANTHER; PTHR10071; PTHR10071; 1.
DR   PANTHER; PTHR10071:SF106; PTHR10071:SF106; 1.
DR   Pfam; PF00320; GATA; 2.
DR   PIRSF; PIRSF003027; TF_GATA-1/2/3; 1.
DR   PRINTS; PR00619; GATAZNFINGER.
DR   SMART; SM00401; ZnF_GATA; 2.
DR   PROSITE; PS00344; GATA_ZN_FINGER_1; 2.
DR   PROSITE; PS50114; GATA_ZN_FINGER_2; 2.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..435
FT                   /note="GATA-binding factor 3"
FT                   /id="PRO_0000083412"
FT   ZN_FING         256..280
FT                   /note="GATA-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00094"
FT   ZN_FING         310..334
FT                   /note="GATA-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00094"
FT   REGION          1..42
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          138..177
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          350..386
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          407..435
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        407..426
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   435 AA;  47520 MW;  5B019EC6D47B80C0 CRC64;
     MEVSAEQPRW VSHPHHPALL NGQHTDSHHQ VHNYMDPSQY PPPEDMDVLF NIDAQGNHVP
     SYYSNSVRTV PRYPPPHHGS LVCHPSILQS WTDGRKSLGG PHAASAWNLP FTKPSIHHNS
     PGGLSVYPPA SSASLATGHS SPHLFTFPPT PPKDVSPDPS ISTSGSTSSS RHEEKECVVS
     KYQVSLGDTG MKLESLHPRN SMSGIGGVSA HHPITTYPDY YGAGLFQPGS ILDGSPTHFS
     SNARPKTRSS TEGRECVNCG ATSTPLWRRD GTGHYLCNAC GLYHKMNGQN RPLIKPKRRL
     SAARRAGTSC ANCQTTTTTL WRRNANGDPV CNACGLYYKL HNINRPLTMK KEGIQTRNRK
     MSSKSKKSKK FHDSLEDYPK SSSFSPAALS RHMSSLSHIP FSHSSHMLTT PTPMHPPSSL
     SFGPHHPSSM VTAMG