GATA4_ARATH
ID GATA4_ARATH Reviewed; 240 AA.
AC O49743;
DT 26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1998, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=GATA transcription factor 4;
DE Short=AtGATA-4;
GN Name=GATA4; OrderedLocusNames=At3g60530; ORFNames=T8B10.190;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC STRAIN=cv. Columbia;
RX PubMed=12139008; DOI=10.1023/a:1016062325584;
RA Teakle G.R., Manfield I.W., Graham J.F., Gilmartin P.M.;
RT "Arabidopsis thaliana GATA factors: organisation, expression and DNA-
RT binding characteristics.";
RL Plant Mol. Biol. 50:43-57(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP GENE FAMILY ORGANIZATION.
RX PubMed=15084732; DOI=10.1104/pp.103.037788;
RA Reyes J.C., Muro-Pastor M.I., Florencio F.J.;
RT "The GATA family of transcription factors in Arabidopsis and rice.";
RL Plant Physiol. 134:1718-1732(2004).
CC -!- FUNCTION: Transcriptional activator that specifically binds 5'-GATA-3'
CC or 5'-GAT-3' motifs within gene promoters. May be involved in the
CC regulation of some light-responsive genes.
CC {ECO:0000269|PubMed:12139008}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in roots, flowers and leaves, and to a
CC lower extent in stems. {ECO:0000269|PubMed:12139008}.
CC -!- SIMILARITY: Belongs to the type IV zinc-finger family. Class A
CC subfamily. {ECO:0000305}.
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DR EMBL; Y13651; CAA74002.1; -; mRNA.
DR EMBL; AL138646; CAB81839.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE80075.1; -; Genomic_DNA.
DR EMBL; AF378881; AAK55684.1; -; mRNA.
DR EMBL; AY039532; AAK62588.1; -; mRNA.
DR EMBL; AY050476; AAK91489.1; -; mRNA.
DR PIR; T47864; T47864.
DR RefSeq; NP_191612.1; NM_115917.5.
DR AlphaFoldDB; O49743; -.
DR SMR; O49743; -.
DR BioGRID; 10538; 19.
DR IntAct; O49743; 19.
DR STRING; 3702.AT3G60530.1; -.
DR PaxDb; O49743; -.
DR PRIDE; O49743; -.
DR ProteomicsDB; 230485; -.
DR EnsemblPlants; AT3G60530.1; AT3G60530.1; AT3G60530.
DR GeneID; 825224; -.
DR Gramene; AT3G60530.1; AT3G60530.1; AT3G60530.
DR KEGG; ath:AT3G60530; -.
DR Araport; AT3G60530; -.
DR TAIR; locus:2103346; AT3G60530.
DR eggNOG; KOG1601; Eukaryota.
DR HOGENOM; CLU_045755_1_1_1; -.
DR InParanoid; O49743; -.
DR OMA; ESELCHS; -.
DR OrthoDB; 1477093at2759; -.
DR PhylomeDB; O49743; -.
DR PRO; PR:O49743; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; O49743; baseline and differential.
DR Genevisible; O49743; AT.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR GO; GO:0009416; P:response to light stimulus; IEP:TAIR.
DR CDD; cd00202; ZnF_GATA; 1.
DR Gene3D; 3.30.50.10; -; 1.
DR InterPro; IPR016679; TF_GATA_pln.
DR InterPro; IPR000679; Znf_GATA.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR Pfam; PF00320; GATA; 1.
DR PIRSF; PIRSF016992; TF_GATA_plant; 1.
DR SMART; SM00401; ZnF_GATA; 1.
DR PROSITE; PS00344; GATA_ZN_FINGER_1; 1.
DR PROSITE; PS50114; GATA_ZN_FINGER_2; 1.
PE 2: Evidence at transcript level;
KW Activator; DNA-binding; Metal-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..240
FT /note="GATA transcription factor 4"
FT /id="PRO_0000083433"
FT ZN_FING 154..208
FT /note="GATA-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00094"
FT REGION 104..124
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 109..116
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
SQ SEQUENCE 240 AA; 26467 MW; D0CD49394D186A56 CRC64;
MDVYGMSSPD LLRIDDLLDF SNDEIFSSSS TVTSSAASSA ASSENPFSFP SSTYTSPTLL
TDFTHDLCVP SDDAAHLEWL SRFVDDSFSD FPANPLTMTV RPEISFTGKP RSRRSRAPAP
SVAGTWAPMS ESELCHSVAK PKPKKVYNAE SVTADGARRC THCASEKTPQ WRTGPLGPKT
LCNACGVRYK SGRLVPEYRP ASSPTFVLTQ HSNSHRKVME LRRQKEQQES CVRIPPFQPQ
