ID   GATA4_CHICK             Reviewed;         380 AA.
AC   P43691;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 136.
DE   RecName: Full=Transcription factor GATA-4;
DE   AltName: Full=GATA-binding factor 4;
DE   Flags: Fragment;
GN   Name=GATA4;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=White leghorn;
RX   PubMed=8083222; DOI=10.1016/s0021-9258(17)31636-8;
RA   Laverriere A.C., Macneill C., Mueller C., Poelmann R.E., Burch J.B.E.,
RA   Evans T.;
RT   "GATA-4/5/6, a subfamily of three transcription factors transcribed in
RT   developing heart and gut.";
RL   J. Biol. Chem. 269:23177-23184(1994).
CC   -!- FUNCTION: Transcriptional activator. Binds to the consensus sequence
CC       5'-AGATAG-3' (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P43694}.
CC   -!- TISSUE SPECIFICITY: More abundant in heart, with lower levels detected
CC       in ovary and small intestine.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U11887; AAA57503.1; -; mRNA.
DR   PIR; I50701; I50701.
DR   RefSeq; NP_001280035.1; NM_001293106.1.
DR   AlphaFoldDB; P43691; -.
DR   SMR; P43691; -.
DR   STRING; 9031.ENSGALP00000030912; -.
DR   PaxDb; P43691; -.
DR   GeneID; 396392; -.
DR   KEGG; gga:396392; -.
DR   CTD; 2626; -.
DR   VEuPathDB; HostDB:geneid_396392; -.
DR   eggNOG; KOG1601; Eukaryota.
DR   HOGENOM; CLU_027524_0_0_1; -.
DR   InParanoid; P43691; -.
DR   PhylomeDB; P43691; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005634; C:nucleus; IDA:AgBase.
DR   GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0045165; P:cell fate commitment; IBA:GO_Central.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0032526; P:response to retinoic acid; TAS:AgBase.
DR   CDD; cd00202; ZnF_GATA; 2.
DR   Gene3D; 3.30.50.10; -; 2.
DR   InterPro; IPR008013; GATA_N.
DR   InterPro; IPR016375; TF_GATA_4/5/6.
DR   InterPro; IPR039355; Transcription_factor_GATA.
DR   InterPro; IPR000679; Znf_GATA.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   PANTHER; PTHR10071; PTHR10071; 1.
DR   Pfam; PF00320; GATA; 2.
DR   Pfam; PF05349; GATA-N; 1.
DR   PIRSF; PIRSF003028; TF_GATA_4/5/6; 1.
DR   PRINTS; PR00619; GATAZNFINGER.
DR   SMART; SM00401; ZnF_GATA; 2.
DR   PROSITE; PS00344; GATA_ZN_FINGER_1; 2.
DR   PROSITE; PS50114; GATA_ZN_FINGER_2; 2.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           <1..380
FT                   /note="Transcription factor GATA-4"
FT                   /id="PRO_0000083416"
FT   ZN_FING         157..181
FT                   /note="GATA-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00094"
FT   ZN_FING         211..235
FT                   /note="GATA-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00094"
FT   REGION          14..73
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          254..316
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        17..73
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        268..299
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
SQ   SEQUENCE   380 AA;  40676 MW;  AC98739846618F0F CRC64;
     PVYVPTTRVP SMLPSLPYLP SSGSSQQASP VSSHSIWTQP GAESAAYNPG SSHPPVSPRF
     SFSTSTPIPS TSSRDAAAAY SSSLSLSANG REQYSRGFGS SYSSPYPAYV SPEMATTWTS
     SPFDSPMLHN LQSRGTPAAA RHANIEFFDD YSEGRECVNC GAMSTPLWRR DGTGHYLCNA
     CGLYHKMNGI NRPLFKPQRR LSASRRVGLS CANCHTTTTT LWRRNAEGEP VCNACGLYMK
     LHGVPRPLAM RKEGIQTRKR KPKNLNKTKT PAGPSSSESL TPTTSSTSSS SSATTTEEMR
     PIKTEPGLSS HYGHPSPISQ AFSVSAMSGH GSSIHPAISA LKLSPQAYQS AISQSPQASS
     KQDSWNSLVL AENHGDIITA