ID   GATA4_XENLA             Reviewed;         392 AA.
AC   Q91677;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=Transcription factor GATA-4;
DE   AltName: Full=GATA-binding factor 4;
DE            Short=xGATA-4;
GN   Name=gata4;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RC   TISSUE=Heart, and Intestine;
RX   PubMed=8631498; DOI=10.1006/dbio.1996.0071;
RA   Jiang Y., Evans T.;
RT   "The Xenopus GATA-4/5/6 genes are associated with cardiac specification and
RT   can regulate cardiac-specific transcription during embryogenesis.";
RL   Dev. Biol. 174:258-270(1996).
CC   -!- FUNCTION: Transcriptional activator that binds to the consensus
CC       sequence 5'-AGATAG-3'. Associated with cardiac specification and can
CC       regulate cardiac-specific transcription during embryogenesis. Activates
CC       the expression of cardiac MHC-alpha in vivo.
CC       {ECO:0000269|PubMed:8631498}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P43694}.
CC   -!- TISSUE SPECIFICITY: Expressed at high levels in heart, small intestine,
CC       stomach, ovary, and liver. Found at much lower levels in lung, spleen,
CC       pancreas and skin.
CC   -!- DEVELOPMENTAL STAGE: Expressed in cardiac progenitors during
CC       embryogenesis and up-regulated during gastrulation.
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DR   EMBL; U45453; AAB05647.1; -; mRNA.
DR   RefSeq; NP_001084098.1; NM_001090629.1.
DR   AlphaFoldDB; Q91677; -.
DR   SMR; Q91677; -.
DR   DNASU; 399302; -.
DR   GeneID; 399302; -.
DR   KEGG; xla:399302; -.
DR   CTD; 399302; -.
DR   Xenbase; XB-GENE-6256576; gata4.S.
DR   Proteomes; UP000186698; Chromosome 5S.
DR   Bgee; 399302; Expressed in heart and 7 other tissues.
DR   GO; GO:0005634; C:nucleus; IDA:MGI.
DR   GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IDA:MGI.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0048738; P:cardiac muscle tissue development; IMP:BHF-UCL.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:MGI.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   CDD; cd00202; ZnF_GATA; 2.
DR   Gene3D; 3.30.50.10; -; 2.
DR   InterPro; IPR008013; GATA_N.
DR   InterPro; IPR016375; TF_GATA_4/5/6.
DR   InterPro; IPR039355; Transcription_factor_GATA.
DR   InterPro; IPR000679; Znf_GATA.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   PANTHER; PTHR10071; PTHR10071; 1.
DR   Pfam; PF00320; GATA; 2.
DR   Pfam; PF05349; GATA-N; 1.
DR   PIRSF; PIRSF003028; TF_GATA_4/5/6; 1.
DR   PRINTS; PR00619; GATAZNFINGER.
DR   SMART; SM00401; ZnF_GATA; 2.
DR   PROSITE; PS00344; GATA_ZN_FINGER_1; 2.
DR   PROSITE; PS50114; GATA_ZN_FINGER_2; 2.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..392
FT                   /note="Transcription factor GATA-4"
FT                   /id="PRO_0000083417"
FT   ZN_FING         184..208
FT                   /note="GATA-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00094"
FT   ZN_FING         238..262
FT                   /note="GATA-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00094"
FT   REGION          75..113
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          279..339
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          359..392
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        294..319
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   392 AA;  42353 MW;  26BFD5AEBA57C2B6 CRC64;
     MYQSIAMATN HGPSGYEGTG SFMHSATAAT SPVYVPTTRV SSMIHSLPYL QTSGSSQQGS
     PVSGHNMWAQ AGVESSAYNP GTSHPPVSPR FTFSSSPPIT APSSREVSYS SPLGISANGR
     EQYSRGLGAT YASPYPAYMS PDMGAAWTAS PFDSSMLHNL QNRAVTSRHP NIEFFDDFSE
     GRECVNCGAM STPLWRRDGT GHYLCNACGL YHKMNGINRP LIKPQRRLSA SRRVGLSCAN
     CHTTTTTLWR RNAEGEPVCN ACGLYMKLHG VPRPLAMKKE GIQTRKRKPK NLSKSKTLTG
     QSGSDSLTPS TSSTNSMGEE MRPIKIEPGL SPPYDHSNSI SQASALSTIT SHGSSYYPMP
     SLKLSPQNHH STFNPSPQAN SKHDSWNNLV LA