GATA5_BOVIN
ID GATA5_BOVIN Reviewed; 403 AA.
AC Q3SZJ5;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Transcription factor GATA-5;
DE AltName: Full=GATA-binding factor 5;
GN Name=GATA5 {ECO:0000250|UniProtKB:Q9BWX5};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transcription factor required during cardiovascular
CC development. Plays an important role in the transcriptional program(s)
CC that underlies smooth muscle cell diversity. Binds to the functionally
CC important CEF-1 nuclear protein binding site in the cardiac-specific
CC slow/cardiac troponin C transcriptional enhancer (By similarity).
CC {ECO:0000250|UniProtKB:P97489, ECO:0000250|UniProtKB:Q9BWX5}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR EMBL; BC102821; AAI02822.1; -; mRNA.
DR RefSeq; NP_001029393.1; NM_001034221.2.
DR AlphaFoldDB; Q3SZJ5; -.
DR SMR; Q3SZJ5; -.
DR STRING; 9913.ENSBTAP00000027184; -.
DR PaxDb; Q3SZJ5; -.
DR PRIDE; Q3SZJ5; -.
DR Ensembl; ENSBTAT00000027184; ENSBTAP00000027184; ENSBTAG00000047944.
DR GeneID; 504784; -.
DR KEGG; bta:504784; -.
DR CTD; 140628; -.
DR VEuPathDB; HostDB:ENSBTAG00000047944; -.
DR VGNC; VGNC:29269; GATA5.
DR eggNOG; KOG1601; Eukaryota.
DR GeneTree; ENSGT00940000160139; -.
DR HOGENOM; CLU_027524_0_0_1; -.
DR InParanoid; Q3SZJ5; -.
DR OMA; CEPGPQP; -.
DR OrthoDB; 807790at2759; -.
DR TreeFam; TF315391; -.
DR Reactome; R-BTA-983231; Factors involved in megakaryocyte development and platelet production.
DR Proteomes; UP000009136; Chromosome 13.
DR Bgee; ENSBTAG00000047944; Expressed in abomasum and 54 other tissues.
DR GO; GO:0000785; C:chromatin; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0003180; P:aortic valve morphogenesis; IEA:Ensembl.
DR GO; GO:0048738; P:cardiac muscle tissue development; IBA:GO_Central.
DR GO; GO:0045165; P:cell fate commitment; IBA:GO_Central.
DR GO; GO:0071773; P:cellular response to BMP stimulus; IEA:Ensembl.
DR GO; GO:0003274; P:endocardial cushion fusion; IEA:Ensembl.
DR GO; GO:0060575; P:intestinal epithelial cell differentiation; IEA:Ensembl.
DR GO; GO:0010614; P:negative regulation of cardiac muscle hypertrophy; IEA:Ensembl.
DR GO; GO:0010629; P:negative regulation of gene expression; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0062000; P:positive regulation of cardiac endothelial to mesenchymal transition; IEA:Ensembl.
DR GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR GO; GO:0035481; P:positive regulation of Notch signaling pathway involved in heart induction; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00202; ZnF_GATA; 2.
DR Gene3D; 3.30.50.10; -; 2.
DR InterPro; IPR008013; GATA_N.
DR InterPro; IPR016375; TF_GATA_4/5/6.
DR InterPro; IPR039355; Transcription_factor_GATA.
DR InterPro; IPR000679; Znf_GATA.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR10071; PTHR10071; 1.
DR Pfam; PF00320; GATA; 2.
DR Pfam; PF05349; GATA-N; 1.
DR PIRSF; PIRSF003028; TF_GATA_4/5/6; 1.
DR PRINTS; PR00619; GATAZNFINGER.
DR SMART; SM00401; ZnF_GATA; 2.
DR PROSITE; PS00344; GATA_ZN_FINGER_1; 2.
DR PROSITE; PS50114; GATA_ZN_FINGER_2; 2.
PE 2: Evidence at transcript level;
KW Activator; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..403
FT /note="Transcription factor GATA-5"
FT /id="PRO_0000289589"
FT ZN_FING 194..218
FT /note="GATA-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00094"
FT ZN_FING 248..272
FT /note="GATA-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00094"
FT REGION 72..111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 291..360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 304..325
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 343..358
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 403 AA; 41603 MW; BCEB21845BBE7955 CRC64;
MYQSLALAPS PGQTAYADSG AFLHTPGAGS PVFVPPARVP SMLPYLPACE PGPQAPAITA
HPGWAQAAAA DSSAFGSGSP HAPAAPPPGT TAFPFAHSSP GPGGGTGTRD NGAFQGAMLA
REQYPAALGR PVSSSYPTAY PAYMSAEVAP SWTSGPLDGS VLHSLQGLPA GLPGRRAPFA
AELLEEFPGE GRECVNCGAL STPLWRRDGT GHYLCNACGL YHKMNGVNRP LVRPQKRLSS
SRRAGLCCTN CHTTTTTLWR RNVDGEPVCN ACGLYMKLHG VPRPLAMKKE SIQTRKRKPK
NIAKTKGSSG SSGHTTASPQ ASVPDPEVSA ATLKPEPSLA SPSCPGPSVT SQGSAQVDDP
LAPSHLEFKF EPEDFALPSA ALGQQAGLGG ALRQEAWCAL ALA
