ID   GATA5_CHICK             Reviewed;         391 AA.
AC   P43692;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 127.
DE   RecName: Full=Transcription factor GATA-5;
DE   AltName: Full=GATA-binding factor 5;
GN   Name=GATA5;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=White leghorn;
RX   PubMed=8083222; DOI=10.1016/s0021-9258(17)31636-8;
RA   Laverriere A.C., Macneill C., Mueller C., Poelmann R.E., Burch J.B.E.,
RA   Evans T.;
RT   "GATA-4/5/6, a subfamily of three transcription factors transcribed in
RT   developing heart and gut.";
RL   J. Biol. Chem. 269:23177-23184(1994).
RN   [2]
RP   FUNCTION, AND DNA-BINDING.
RX   PubMed=15329343; DOI=10.1242/dev.01344;
RA   Lee K.H., Evans S., Ruan T.Y., Lassar A.B.;
RT   "SMAD-mediated modulation of YY1 activity regulates the BMP response and
RT   cardiac-specific expression of a GATA4/5/6-dependent chick Nkx2.5
RT   enhancer.";
RL   Development 131:4709-4723(2004).
CC   -!- FUNCTION: Probably involved in bone morphogenetic protein (BMP)-
CC       mediated cardiac-specific gene expression. Binds to BMP response
CC       element (BMPRE) DNA sequences within cardiac activating regions.
CC       {ECO:0000269|PubMed:15329343}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- TISSUE SPECIFICITY: More abundant in stomach and small intestine, lower
CC       levels in heart, lung and spleen. Very low levels in liver and ovary.
CC   -!- DEVELOPMENTAL STAGE: Initially transcribed in the cardiac crescent
CC       prior to formation of the primordial heart tube. Following formation of
CC       the primitive heart, present in both endocardium and myocardium as well
CC       as in other lateral plate derivatives. Also transcribed in the
CC       primitive embryonic gut and in late stage embryos is sequentially up-
CC       regulated in distinct segments of gastrointestinal epithelia as they
CC       undergo terminal differentiation.
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DR   EMBL; U11888; AAA57504.1; -; mRNA.
DR   PIR; I50702; I50702.
DR   AlphaFoldDB; P43692; -.
DR   SMR; P43692; -.
DR   STRING; 9031.ENSGALP00000008569; -.
DR   PaxDb; P43692; -.
DR   VEuPathDB; HostDB:geneid_396391; -.
DR   eggNOG; KOG1601; Eukaryota.
DR   InParanoid; P43692; -.
DR   OrthoDB; 807790at2759; -.
DR   PhylomeDB; P43692; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005634; C:nucleus; IMP:AgBase.
DR   GO; GO:0000987; F:cis-regulatory region sequence-specific DNA binding; IMP:AgBase.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00202; ZnF_GATA; 2.
DR   Gene3D; 3.30.50.10; -; 2.
DR   InterPro; IPR008013; GATA_N.
DR   InterPro; IPR016375; TF_GATA_4/5/6.
DR   InterPro; IPR039355; Transcription_factor_GATA.
DR   InterPro; IPR000679; Znf_GATA.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   PANTHER; PTHR10071; PTHR10071; 1.
DR   Pfam; PF00320; GATA; 2.
DR   Pfam; PF05349; GATA-N; 1.
DR   PIRSF; PIRSF003028; TF_GATA_4/5/6; 1.
DR   PRINTS; PR00619; GATAZNFINGER.
DR   SMART; SM00401; ZnF_GATA; 2.
DR   PROSITE; PS00344; GATA_ZN_FINGER_1; 2.
DR   PROSITE; PS50114; GATA_ZN_FINGER_2; 2.
PE   1: Evidence at protein level;
KW   Activator; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..391
FT                   /note="Transcription factor GATA-5"
FT                   /id="PRO_0000083420"
FT   ZN_FING         186..210
FT                   /note="GATA-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00094"
FT   ZN_FING         239..263
FT                   /note="GATA-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00094"
FT   REGION          53..100
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          281..378
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        53..80
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        295..349
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   391 AA;  41859 MW;  EF8A283111824260 CRC64;
     MYQGLALAPN HGQSAYSHDS GNFLHSSAGS PVYVPTTRVP SVLQTLPYLQ SCEPHQSHLG
     NPPGWAQSSG ETTAFNAGSP HPPSGFSYPH SPRAAAPRGV DGAYQGPLLL GGGGREQYGN
     ALVRSVNGSY SSPYPAYVTP ELPPSWTAGH FESSVLHSLQ TRQAALPGRR STFEYLEEFP
     GDGRECVNCG AMSTPLWRKD GTGHYLCNAC GLYHKMNGIN RPLKPQKRLS SSRRAGLCCT
     NCHTTNTTLW RRNAEGEPVC NACGLYMKLH GVPRPLAMKK ESIQTRKRKP KNITKGKTST
     GSTTSATNSP SSITNSDSTV TLKSEPSTTS QYPGQGIVSV SQAQSQSDEA LAGGEFKFEP
     EDYPFSPSSM APQPGLSVPL RQDSWCALAL A