GATA5_MOUSE
ID GATA5_MOUSE Reviewed; 404 AA.
AC P97489; Q3UQR0;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 161.
DE RecName: Full=Transcription factor GATA-5;
DE AltName: Full=GATA-binding factor 5;
GN Name=Gata5 {ECO:0000312|MGI:MGI:109497};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RC STRAIN=BALB/cJ;
RX PubMed=9119112; DOI=10.1006/dbio.1996.8485;
RA Morrisey E.E., Ip H.S., Tang Z., Lu M.M., Parmacek M.S.;
RT "GATA-5: a transcriptional activator expressed in a novel temporally and
RT spatially-restricted pattern during embryonic development.";
RL Dev. Biol. 183:21-36(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Heart;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Lung;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Transcription factor required during cardiovascular
CC development (By similarity). Plays an important role in the
CC transcriptional program(s) that underlies smooth muscle cell diversity
CC (PubMed:9119112). Binds to the functionally important CEF-1 nuclear
CC protein binding site in the cardiac-specific slow/cardiac troponin C
CC transcriptional enhancer (By similarity).
CC {ECO:0000250|UniProtKB:Q9BWX5, ECO:0000269|PubMed:9119112}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
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DR EMBL; U84725; AAB47506.1; -; mRNA.
DR EMBL; AK132020; BAE20945.1; -; mRNA.
DR EMBL; AK142213; BAE24979.1; -; mRNA.
DR EMBL; AL663027; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466626; EDL07330.1; -; Genomic_DNA.
DR CCDS; CCDS17175.1; -.
DR RefSeq; NP_032119.2; NM_008093.2.
DR RefSeq; XP_006500617.1; XM_006500554.3.
DR AlphaFoldDB; P97489; -.
DR SMR; P97489; -.
DR BioGRID; 199842; 5.
DR IntAct; P97489; 3.
DR STRING; 10090.ENSMUSP00000015771; -.
DR iPTMnet; P97489; -.
DR PhosphoSitePlus; P97489; -.
DR MaxQB; P97489; -.
DR PaxDb; P97489; -.
DR PeptideAtlas; P97489; -.
DR PRIDE; P97489; -.
DR ProteomicsDB; 265727; -.
DR Antibodypedia; 29533; 270 antibodies from 35 providers.
DR DNASU; 14464; -.
DR Ensembl; ENSMUST00000015771; ENSMUSP00000015771; ENSMUSG00000015627.
DR GeneID; 14464; -.
DR KEGG; mmu:14464; -.
DR UCSC; uc008oix.2; mouse.
DR CTD; 140628; -.
DR MGI; MGI:109497; Gata5.
DR VEuPathDB; HostDB:ENSMUSG00000015627; -.
DR eggNOG; KOG1601; Eukaryota.
DR GeneTree; ENSGT00940000160139; -.
DR HOGENOM; CLU_027524_0_0_1; -.
DR InParanoid; P97489; -.
DR OMA; CEPGPQP; -.
DR OrthoDB; 807790at2759; -.
DR PhylomeDB; P97489; -.
DR TreeFam; TF315391; -.
DR Reactome; R-MMU-983231; Factors involved in megakaryocyte development and platelet production.
DR BioGRID-ORCS; 14464; 4 hits in 71 CRISPR screens.
DR PRO; PR:P97489; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; P97489; protein.
DR Bgee; ENSMUSG00000015627; Expressed in small intestine Peyer's patch and 76 other tissues.
DR Genevisible; P97489; MM.
DR GO; GO:0000785; C:chromatin; IDA:BHF-UCL.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0000987; F:cis-regulatory region sequence-specific DNA binding; IDA:UniProtKB.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISO:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IDA:BHF-UCL.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:MGI.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IDA:MGI.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0003180; P:aortic valve morphogenesis; IMP:BHF-UCL.
DR GO; GO:0048738; P:cardiac muscle tissue development; IBA:GO_Central.
DR GO; GO:0045165; P:cell fate commitment; IBA:GO_Central.
DR GO; GO:0071773; P:cellular response to BMP stimulus; IDA:MGI.
DR GO; GO:0003274; P:endocardial cushion fusion; IMP:BHF-UCL.
DR GO; GO:0007507; P:heart development; IDA:BHF-UCL.
DR GO; GO:0060575; P:intestinal epithelial cell differentiation; ISO:MGI.
DR GO; GO:0010614; P:negative regulation of cardiac muscle hypertrophy; IMP:BHF-UCL.
DR GO; GO:0010629; P:negative regulation of gene expression; IMP:BHF-UCL.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0062000; P:positive regulation of cardiac endothelial to mesenchymal transition; IMP:BHF-UCL.
DR GO; GO:0010628; P:positive regulation of gene expression; IMP:BHF-UCL.
DR GO; GO:0035481; P:positive regulation of Notch signaling pathway involved in heart induction; IMP:BHF-UCL.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:BHF-UCL.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:MGI.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IDA:MGI.
DR CDD; cd00202; ZnF_GATA; 2.
DR Gene3D; 3.30.50.10; -; 2.
DR InterPro; IPR008013; GATA_N.
DR InterPro; IPR016375; TF_GATA_4/5/6.
DR InterPro; IPR039355; Transcription_factor_GATA.
DR InterPro; IPR000679; Znf_GATA.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR10071; PTHR10071; 1.
DR Pfam; PF00320; GATA; 2.
DR Pfam; PF05349; GATA-N; 1.
DR PIRSF; PIRSF003028; TF_GATA_4/5/6; 1.
DR PRINTS; PR00619; GATAZNFINGER.
DR SMART; SM00401; ZnF_GATA; 2.
DR PROSITE; PS00344; GATA_ZN_FINGER_1; 2.
DR PROSITE; PS50114; GATA_ZN_FINGER_2; 2.
PE 1: Evidence at protein level;
KW Activator; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..404
FT /note="Transcription factor GATA-5"
FT /id="PRO_0000083419"
FT ZN_FING 196..220
FT /note="GATA-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00094"
FT ZN_FING 250..274
FT /note="GATA-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00094"
FT REGION 71..112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 293..332
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 307..332
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 67
FT /note="A -> T (in Ref. 1; AAB47506)"
FT /evidence="ECO:0000305"
FT CONFLICT 302
FT /note="K -> E (in Ref. 1; AAB47506)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 404 AA; 42114 MW; 6C0990A85D594F0C CRC64;
MYQSLALAQS PGQGTYADSG AFLHSSGTGS PVFVAPTRMP SMLPYLPSCE PGSQAPALAA
HSSWTQAVAA DSSAFGSGSP HPPAAHPPGA TTFPFAHSPP GSGSGGSAGV RDGGAFQGAL
LAREQYPTPL GRPMGASYPT TYPAYMSSDV APSWTSGAFD SSILHGLQAR PGGLPGRRTS
FVPDFLEEFP GEGRECVNCG ALSTPLWRRD GTGHYLCNAC GLYHKMNGVN RPLVRPQKRL
SSSRRSGLCC SNCHTATTTL WRRNSEGEPV CNACGLYMKL HGVPRPLAMK KESIQTRKRK
PKNPAKIKGS SGSTANTTAS SPTLLNSESS ATTLKAESSL ASPVCAGPTI TSQASSPADE
SLASSHLEFK FEPEDFAFTS SSMSPQAGLS GVLRQETWCA LALA
